Artículos

Aripiprazole for the treatment of schizophrenia with co occurring social anxiety / Robert G. Stern en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 206-209 Título : Aripiprazole for the treatment of schizophrenia with co occurring social anxiety : An open label cross taper study Tipo de documento: texto impreso Autores: Robert G. Stern, Autor ; Theodore A. Petti, Autor ; Kurt Bopp, Autor Fecha de publicación: 2022 Artículo en la página: pp. 206-209 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Esquizofrenia, Concurrente, Ansiedad social, Aripiprazol Resumen: Co-occurring social anxiety in patients with schizophrenia is common and often severe. Pharmacologic agents with serotonin receptor 1A agonist properties such as aripiprazole are believed to be effective anxiolytic drugs. Link: ./index.php?lvl=notice_display&id=29499 [artículo] Aripiprazole for the treatment of schizophrenia with co occurring social anxiety : An open label cross taper study [texto impreso] / Robert G. Stern, Autor ; Theodore A. Petti, Autor ; Kurt Bopp, Autor . - 2022 . - pp. 206-209. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 206-209 Palabras clave: Esquizofrenia, Concurrente, Ansiedad social, Aripiprazol Resumen: Co-occurring social anxiety in patients with schizophrenia is common and often severe. Pharmacologic agents with serotonin receptor 1A agonist properties such as aripiprazole are believed to be effective anxiolytic drugs. Link: ./index.php?lvl=notice_display&id=29499

Association of posttraumatic stress disorder with increased prevalence of metabolic syndrome / Hua Jin en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 210-215 Título : Association of posttraumatic stress disorder with increased prevalence of metabolic syndrome Tipo de documento: texto impreso Autores: Hua Jin, Autor ; Nicole M. Lanouette, Autor ; Sunder Mudaliar, Autor Fecha de publicación: 2022 Artículo en la página: pp. 210-215 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: TEPT, Trastornos psicóticos, Síndrome metabólico Resumen: Few studies have compared prevalence rates of metabolic abnormalities in antipsychotic-treated patients with different psychiatric disorders, including posttraumatic stress disorder (PTSD). In this study, we examined components of metabolic syndrome among middle-aged and older patients with psychiatric disorders. Link: ./index.php?lvl=notice_display&id=29500 [artículo] Association of posttraumatic stress disorder with increased prevalence of metabolic syndrome [texto impreso] / Hua Jin, Autor ; Nicole M. Lanouette, Autor ; Sunder Mudaliar, Autor . - 2022 . - pp. 210-215. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 210-215 Palabras clave: TEPT, Trastornos psicóticos, Síndrome metabólico Resumen: Few studies have compared prevalence rates of metabolic abnormalities in antipsychotic-treated patients with different psychiatric disorders, including posttraumatic stress disorder (PTSD). In this study, we examined components of metabolic syndrome among middle-aged and older patients with psychiatric disorders. Link: ./index.php?lvl=notice_display&id=29500

Effects of testosterone replacement in middle aged men with dysthymia / Stuart N. Seidman en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 216-221 Título : Effects of testosterone replacement in middle aged men with dysthymia : A randomized, placebo controlled clinical trial Tipo de documento: texto impreso Autores: Stuart N. Seidman, Autor ; Guy Orr, Autor ; Gil Raviv, Autor Fecha de publicación: 2022 Artículo en la página: pp. 216-221 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Testosterona, Masculino, Distimia, Andropausia, Hipogonadismo Resumen: Mid-life onset male dysthymic disorder (DD) seems to be a distinct clinical condition with limited therapeutic options. Testosterone replacement is mood-enhancing and has been proposed as an antidepressant therapy, though this strategy has received limited systematic study. Link: ./index.php?lvl=notice_display&id=29501 [artículo] Effects of testosterone replacement in middle aged men with dysthymia : A randomized, placebo controlled clinical trial [texto impreso] / Stuart N. Seidman, Autor ; Guy Orr, Autor ; Gil Raviv, Autor . - 2022 . - pp. 216-221. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 216-221 Palabras clave: Testosterona, Masculino, Distimia, Andropausia, Hipogonadismo Resumen: Mid-life onset male dysthymic disorder (DD) seems to be a distinct clinical condition with limited therapeutic options. Testosterone replacement is mood-enhancing and has been proposed as an antidepressant therapy, though this strategy has received limited systematic study. Link: ./index.php?lvl=notice_display&id=29501

Zolpidem extended release improves sleep and next day symptoms in comorbid insomnia and generalized anxiety disorder / Maurizio Fava en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 222-230 Título : Zolpidem extended release improves sleep and next day symptoms in comorbid insomnia and generalized anxiety disorder Tipo de documento: texto impreso Autores: Maurizio Fava, Autor ; Gregory M. Asnis, Autor ; Ram K. Shrivastava, Autor Fecha de publicación: 2022 Artículo en la página: pp. 222-230 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Zolpidem de liberación prolongada, Insomnio, Trastorno de ansiedad generalizada, Ensayo controlado aleatorio, Farmacoterapia concomitante, Escitalopram Resumen: A multicenter, double-blind, parallel-group study was designed to assess the efficacy and safety of zolpidem extended-release coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder. Patients (N = 383) received open-label escitalopram 10 mg/d and were randomized to either adjunct zolpidem extended-release 12.5 mg or placebo. Link: ./index.php?lvl=notice_display&id=29502 [artículo] Zolpidem extended release improves sleep and next day symptoms in comorbid insomnia and generalized anxiety disorder [texto impreso] / Maurizio Fava, Autor ; Gregory M. Asnis, Autor ; Ram K. Shrivastava, Autor . - 2022 . - pp. 222-230. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 222-230 Palabras clave: Zolpidem de liberación prolongada, Insomnio, Trastorno de ansiedad generalizada, Ensayo controlado aleatorio, Farmacoterapia concomitante, Escitalopram Resumen: A multicenter, double-blind, parallel-group study was designed to assess the efficacy and safety of zolpidem extended-release coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder. Patients (N = 383) received open-label escitalopram 10 mg/d and were randomized to either adjunct zolpidem extended-release 12.5 mg or placebo. Link: ./index.php?lvl=notice_display&id=29502

Methadone-nicotine interactions in methadone maintenance treatment patients / Alexander K. Elkader en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 231-238 Título : Methadone-nicotine interactions in methadone maintenance treatment patients Tipo de documento: texto impreso Autores: Alexander K. Elkader, Autor ; Bruna Brands, Autor ; Peter Selby, Autor Fecha de publicación: 2022 Artículo en la página: pp. 231-238 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Metadona, Nicotina, Interacción, MMT Resumen: Smoking is highly prevalent (85%-98%) in methadone maintenance treatment (MMT) patients. Methadone has been shown to increase cigarette smoking in a dose-dependent manner, whereas smoking/nicotine has been shown to increase methadone self-administration and reinforcing properties. Link: ./index.php?lvl=notice_display&id=29503 [artículo] Methadone-nicotine interactions in methadone maintenance treatment patients [texto impreso] / Alexander K. Elkader, Autor ; Bruna Brands, Autor ; Peter Selby, Autor . - 2022 . - pp. 231-238. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 231-238 Palabras clave: Metadona, Nicotina, Interacción, MMT Resumen: Smoking is highly prevalent (85%-98%) in methadone maintenance treatment (MMT) patients. Methadone has been shown to increase cigarette smoking in a dose-dependent manner, whereas smoking/nicotine has been shown to increase methadone self-administration and reinforcing properties. Link: ./index.php?lvl=notice_display&id=29503

Efficacy and safety of oros methylphenidate in adults with attention-deficit/hyperactivity disorder / Lenard Adler en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 239-247 Título : Efficacy and safety of oros methylphenidate in adults with attention-deficit/hyperactivity disorder : A randomized, placebo-controlled, double-blind, parallel group, dose-escalation study Tipo de documento: texto impreso Autores: Lenard Adler, Autor ; Brenda Zimmerman, Autor ; H. Lynn Starr, Autor Fecha de publicación: 2022 Artículo en la página: pp. 239-247 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Metilfenidato de OROS, Trastorno por Déficit de Atención e Hiperactividad en adultos, Estimulante Resumen: To assess the efficacy and safety of OROS methylphenidate (Concerta; McNeil Pediatrics Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc, Titusville, NJ) in the management of attention-deficit/hyperactivity disorder (ADHD) in adults. Link: ./index.php?lvl=notice_display&id=29504 [artículo] Efficacy and safety of oros methylphenidate in adults with attention-deficit/hyperactivity disorder : A randomized, placebo-controlled, double-blind, parallel group, dose-escalation study [texto impreso] / Lenard Adler, Autor ; Brenda Zimmerman, Autor ; H. Lynn Starr, Autor . - 2022 . - pp. 239-247. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 239-247 Palabras clave: Metilfenidato de OROS, Trastorno por Déficit de Atención e Hiperactividad en adultos, Estimulante Resumen: To assess the efficacy and safety of OROS methylphenidate (Concerta; McNeil Pediatrics Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc, Titusville, NJ) in the management of attention-deficit/hyperactivity disorder (ADHD) in adults. Link: ./index.php?lvl=notice_display&id=29504

Evaluation of a urine on-site drugs of abuse screening test in patients admitted to a psychiatric emergency unit / Gunnhild Bagøien en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 248-254 Título : Evaluation of a urine on-site drugs of abuse screening test in patients admitted to a psychiatric emergency unit Tipo de documento: texto impreso Autores: Gunnhild Bagøien, Autor ; Gunnar Morken, Autor ; Kolbjørn Zahlsen, Autor Fecha de publicación: 2022 Artículo en la página: pp. 248-254 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Prueba de detección de drogas en orina in situ, Abuso de sustancias, Unidad de emergencia psiquiátrica Resumen: The objective of this study was to characterize the usefulness and reliability of a commonly used urinary on-site drugs of abuse screening test device when used routinely at admittances to a psychiatric emergency unit. Link: ./index.php?lvl=notice_display&id=29505 [artículo] Evaluation of a urine on-site drugs of abuse screening test in patients admitted to a psychiatric emergency unit [texto impreso] / Gunnhild Bagøien, Autor ; Gunnar Morken, Autor ; Kolbjørn Zahlsen, Autor . - 2022 . - pp. 248-254. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 248-254 Palabras clave: Prueba de detección de drogas en orina in situ, Abuso de sustancias, Unidad de emergencia psiquiátrica Resumen: The objective of this study was to characterize the usefulness and reliability of a commonly used urinary on-site drugs of abuse screening test device when used routinely at admittances to a psychiatric emergency unit. Link: ./index.php?lvl=notice_display&id=29505

Synthetic Δ-9-tetrahydrocannabinol (dronabinol) can improve the symptoms of schizophrenia / Glenn Schwarcz en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 255-258 Título : Synthetic Δ-9-tetrahydrocannabinol (dronabinol) can improve the symptoms of schizophrenia Tipo de documento: texto impreso Autores: Glenn Schwarcz, Autor ; Basawaraj Karajgi, Autor ; Richard McCarthy, Autor Fecha de publicación: 2022 Artículo en la página: pp. 255-258 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Hipótesis cannabinoide de la esquizofrenia, Estimulación endocannabinoide Resumen: We are reporting improvement of symptoms of schizophrenia in a small group of patients who received the cannabinoid agonist dronabinol (synthetic Δ-9-tetrahydrocannabinol). Before this report, cannabinoids had usually been associated with worsening of psychotic symptoms. Link: ./index.php?lvl=notice_display&id=29506 [artículo] Synthetic Δ-9-tetrahydrocannabinol (dronabinol) can improve the symptoms of schizophrenia [texto impreso] / Glenn Schwarcz, Autor ; Basawaraj Karajgi, Autor ; Richard McCarthy, Autor . - 2022 . - pp. 255-258. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 255-258 Palabras clave: Hipótesis cannabinoide de la esquizofrenia, Estimulación endocannabinoide Resumen: We are reporting improvement of symptoms of schizophrenia in a small group of patients who received the cannabinoid agonist dronabinol (synthetic Δ-9-tetrahydrocannabinol). Before this report, cannabinoids had usually been associated with worsening of psychotic symptoms. Link: ./index.php?lvl=notice_display&id=29506

Treatment emergent sexual dysfunction related to antidepressants / Alessandro Serretti en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 259-266 Título : Treatment emergent sexual dysfunction related to antidepressants : A meta analysis Tipo de documento: texto impreso Autores: Alessandro Serretti, Autor ; Alberto Chiesa, Autor Fecha de publicación: 2022 Artículo en la página: pp. 259-266 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, ISRS, Inhibidores de la recaptación de serotonina, Noradrenalina, Disfunción sexual Resumen: Sexual dysfunction (SD) is an important underestimated adverse effect of antidepressant drugs. Patients, in fact, if not directly questioned, tend to scarcely report them. The aim of the present meta-analysis was to quantify SD caused by antidepressants on the basis of studies where sexual functioning was purposely investigated through direct inquiry and specific questionnaires. Link: ./index.php?lvl=notice_display&id=29507 [artículo] Treatment emergent sexual dysfunction related to antidepressants : A meta analysis [texto impreso] / Alessandro Serretti, Autor ; Alberto Chiesa, Autor . - 2022 . - pp. 259-266. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 259-266 Palabras clave: Antidepresivos, ISRS, Inhibidores de la recaptación de serotonina, Noradrenalina, Disfunción sexual Resumen: Sexual dysfunction (SD) is an important underestimated adverse effect of antidepressant drugs. Patients, in fact, if not directly questioned, tend to scarcely report them. The aim of the present meta-analysis was to quantify SD caused by antidepressants on the basis of studies where sexual functioning was purposely investigated through direct inquiry and specific questionnaires. Link: ./index.php?lvl=notice_display&id=29507

A double blind randomized trial of mood stabilizer augmentation using lamotrigine and valproate for patients with schizophrenia who are stabilized and partially responsive / Ira D. Glick en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 267-271 Título : A double blind randomized trial of mood stabilizer augmentation using lamotrigine and valproate for patients with schizophrenia who are stabilized and partially responsive Tipo de documento: texto impreso Autores: Ira D. Glick, Autor ; Jeane Bosch, Autor ; Daniel E. Casey, Autor Fecha de publicación: 2022 Artículo en la página: pp. 267-271 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Esquizofrenia, Estabilizadores del estado de ánimo, Medicamentos concomitantes Resumen: To compare the efficacy of mood stabilizer augmentation of an antipsychotic for patients with schizophrenia who are both stabilized and partially responsive. Link: ./index.php?lvl=notice_display&id=29508 [artículo] A double blind randomized trial of mood stabilizer augmentation using lamotrigine and valproate for patients with schizophrenia who are stabilized and partially responsive [texto impreso] / Ira D. Glick, Autor ; Jeane Bosch, Autor ; Daniel E. Casey, Autor . - 2022 . - pp. 267-271. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 267-271 Palabras clave: Esquizofrenia, Estabilizadores del estado de ánimo, Medicamentos concomitantes Resumen: To compare the efficacy of mood stabilizer augmentation of an antipsychotic for patients with schizophrenia who are both stabilized and partially responsive. Link: ./index.php?lvl=notice_display&id=29508

Effects of cyp2d6 and cyp3a5 genotypes on the plasma concentrations of risperidone and 9-hydroxyrisperidone in korean schizophrenic patients / Rhee Hun Kang en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 272-277 Título : Effects of cyp2d6 and cyp3a5 genotypes on the plasma concentrations of risperidone and 9-hydroxyrisperidone in korean schizophrenic patients Tipo de documento: texto impreso Autores: Rhee Hun Kang, Autor ; Sun Min Jung, Autor ; Kyoung Ah Kim, Autor Fecha de publicación: 2022 Artículo en la página: pp. 272-277 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Risperidona, Citocromo P450 2D6 (CYP2D6), Citocromo P450 3A5 (CYP3A5), 9-hidroxirisperidona, Farmacogenética Resumen: This study was conducted to evaluate the effects of the CYP2D6 and CYP3A5 genotypes on the steady-state plasma levels of risperidone (RIS), 9-hydroxyrisperidone (9-OH-RIS), and the active moiety (RIS plus 9-OH-RIS) in Korean schizophrenic patients. Sixty-four Korean schizophrenic patients were enrolled. Link: ./index.php?lvl=notice_display&id=29509 [artículo] Effects of cyp2d6 and cyp3a5 genotypes on the plasma concentrations of risperidone and 9-hydroxyrisperidone in korean schizophrenic patients [texto impreso] / Rhee Hun Kang, Autor ; Sun Min Jung, Autor ; Kyoung Ah Kim, Autor . - 2022 . - pp. 272-277. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 272-277 Palabras clave: Risperidona, Citocromo P450 2D6 (CYP2D6), Citocromo P450 3A5 (CYP3A5), 9-hidroxirisperidona, Farmacogenética Resumen: This study was conducted to evaluate the effects of the CYP2D6 and CYP3A5 genotypes on the steady-state plasma levels of risperidone (RIS), 9-hydroxyrisperidone (9-OH-RIS), and the active moiety (RIS plus 9-OH-RIS) in Korean schizophrenic patients. Sixty-four Korean schizophrenic patients were enrolled. Link: ./index.php?lvl=notice_display&id=29509

Olanzapine plasma concentrations after treatment with 10, 20, and 40 mg/d in patients with schizophrenia / Leslie L. Citrome en Journal of Clinical Psychopharmacology, Año 2009 - Vol. 29 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 278-283 Título : Olanzapine plasma concentrations after treatment with 10, 20, and 40 mg/d in patients with schizophrenia : An analysis of correlations with efficacy, weight gain, and prolactin concentration Tipo de documento: texto impreso Autores: Leslie L. Citrome, Autor ; Virginia L. Stauffer, Autor ; Lei Chen, Autor Fecha de publicación: 2022 Artículo en la página: pp. 278-283 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Olanzapina, Farmacocinética, Prolactina, Esquizofrenia, Tabaquismo. Resumen: Objectives of the study were to evaluate the relationship between olanzapine plasma concentrations and efficacy, prolactin, and weight and to assess effects of smoking, sex, and race on the pharmacokinetic characteristics of oral olanzapine up to 40 mg/d. Patients were randomly allocated to olanzapine 10, 20, or 40 mg/d for 8 weeks. Olanzapine concentrations in 634 samples from 380 patients were analyzed. Link: ./index.php?lvl=notice_display&id=29510 [artículo] Olanzapine plasma concentrations after treatment with 10, 20, and 40 mg/d in patients with schizophrenia : An analysis of correlations with efficacy, weight gain, and prolactin concentration [texto impreso] / Leslie L. Citrome, Autor ; Virginia L. Stauffer, Autor ; Lei Chen, Autor . - 2022 . - pp. 278-283. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2009 - Vol. 29 - No. 3 (Junio) . - pp. 278-283 Palabras clave: Olanzapina, Farmacocinética, Prolactina, Esquizofrenia, Tabaquismo. Resumen: Objectives of the study were to evaluate the relationship between olanzapine plasma concentrations and efficacy, prolactin, and weight and to assess effects of smoking, sex, and race on the pharmacokinetic characteristics of oral olanzapine up to 40 mg/d. Patients were randomly allocated to olanzapine 10, 20, or 40 mg/d for 8 weeks. Olanzapine concentrations in 634 samples from 380 patients were analyzed. Link: ./index.php?lvl=notice_display&id=29510