Biblioteca Humberto Rosselli Quijano
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Autor Benoit H. Mulsant |
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Pharmacologic profile of perphenazine's metabolites / Robert A. Sweet en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)
[artículo]
Título : Pharmacologic profile of perphenazine's metabolites Tipo de documento: texto impreso Autores: Robert A. Sweet, Autor ; Bruce G. Pollock, Autor ; Benoit H. Mulsant, Autor Fecha de publicación: 2023 Artículo en la página: pp. 181-187 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Efectos cerebrales, Demencia, Antagonistas de la dopamina, Perfenazina. Resumen: The authors have previously reported that in elderly patients treated with low doses of perphenazine, few extrapyramidal symptoms (EPS) developed in those who were not poor CYP2D6 metabolizers. The authors hypothesized that this atypical side effect profile is due to perphenazine's principal metabolite, n-dealkylperphenazine (DAPZ), which is usually present in vivo at concentrations 1.5 to 2 times that of the parent drug. Link: ./index.php?lvl=notice_display&id=31213
in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 181-187[artículo] Pharmacologic profile of perphenazine's metabolites [texto impreso] / Robert A. Sweet, Autor ; Bruce G. Pollock, Autor ; Benoit H. Mulsant, Autor . - 2023 . - pp. 181-187.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 181-187
Palabras clave: Antipsicóticos, Efectos cerebrales, Demencia, Antagonistas de la dopamina, Perfenazina. Resumen: The authors have previously reported that in elderly patients treated with low doses of perphenazine, few extrapyramidal symptoms (EPS) developed in those who were not poor CYP2D6 metabolizers. The authors hypothesized that this atypical side effect profile is due to perphenazine's principal metabolite, n-dealkylperphenazine (DAPZ), which is usually present in vivo at concentrations 1.5 to 2 times that of the parent drug. Link: ./index.php?lvl=notice_display&id=31213 Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to n-desmethylclozapine / Tarek K. Rajji en The American Journal of Psychiatry, Año 2015 - Vol. 172 - No.6 (Junio)
[artículo]
Título : Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to n-desmethylclozapine Tipo de documento: texto impreso Autores: Tarek K. Rajji, Autor ; Benoit H. Mulsant, Autor ; Simon Davies, Autor Fecha de publicación: 2020 Artículo en la página: pp. 579-585 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Clozapina, Memoria, Pruebas neuropsicológicas, Psicometría, Trastornos psicóticos, Esquizofrenia. Resumen: Clozapine’s potent antagonism of muscarinic M1 receptors is thought to worsen working memory deficits associated with schizophrenia. In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working memory via its M1 receptor agonist activity. Link: ./index.php?lvl=notice_display&id=22284
in The American Journal of Psychiatry > Año 2015 - Vol. 172 - No.6 (Junio) . - pp. 579-585[artículo] Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to n-desmethylclozapine [texto impreso] / Tarek K. Rajji, Autor ; Benoit H. Mulsant, Autor ; Simon Davies, Autor . - 2020 . - pp. 579-585.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in The American Journal of Psychiatry > Año 2015 - Vol. 172 - No.6 (Junio) . - pp. 579-585
Palabras clave: Clozapina, Memoria, Pruebas neuropsicológicas, Psicometría, Trastornos psicóticos, Esquizofrenia. Resumen: Clozapine’s potent antagonism of muscarinic M1 receptors is thought to worsen working memory deficits associated with schizophrenia. In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working memory via its M1 receptor agonist activity. Link: ./index.php?lvl=notice_display&id=22284