Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to n-desmethylclozapine / Tarek K. Rajji en The American Journal of Psychiatry, Año 2015 - Vol. 172 - No.6 (Junio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2015 - Vol. 172 - No.6 (Junio) . - pp. 579-585 Título : Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to n-desmethylclozapine Tipo de documento: texto impreso Autores: Tarek K. Rajji, Autor ; Benoit H. Mulsant, Autor ; Simon Davies, Autor Fecha de publicación: 2020 Artículo en la página: pp. 579-585 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Clozapina, Memoria, Pruebas neuropsicológicas, Psicometría, Trastornos psicóticos, Esquizofrenia. Resumen: Clozapine’s potent antagonism of muscarinic M1 receptors is thought to worsen working memory deficits associated with schizophrenia. In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working memory via its M1 receptor agonist activity. Link: ./index.php?lvl=notice_display&id=22284 [artículo] Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to n-desmethylclozapine [texto impreso] / Tarek K. Rajji, Autor ; Benoit H. Mulsant, Autor ; Simon Davies, Autor . - 2020 . - pp. 579-585. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2015 - Vol. 172 - No.6 (Junio) . - pp. 579-585 Palabras clave: Clozapina, Memoria, Pruebas neuropsicológicas, Psicometría, Trastornos psicóticos, Esquizofrenia. Resumen: Clozapine’s potent antagonism of muscarinic M1 receptors is thought to worsen working memory deficits associated with schizophrenia. In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working memory via its M1 receptor agonist activity. Link: ./index.php?lvl=notice_display&id=22284

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