Artículos

Polygenic scores in psychiatry / Cathryn M. Lewis en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 11 (Noviembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 800-806 Título : Polygenic scores in psychiatry : on the road from discovery to implementation Tipo de documento: texto impreso Autores: Cathryn M. Lewis, Autor ; Evangelos Vassos, Autor Fecha de publicación: 2023 Artículo en la página: pp. 800-806 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Genética - Genómica, Puntuaciones poligénicas, Factores de Riesgo Ambiental Resumen: The hypothesis that multiple genetic variants contribute to psychiatric disorders was first proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic contribution of genetic variants, which leads to a continuous liability disease, arose long before molecular genetic studies allowed us to identify specific genetic markers associated with mental disorders. Link: ./index.php?lvl=notice_display&id=29763 [artículo] Polygenic scores in psychiatry : on the road from discovery to implementation [texto impreso] / Cathryn M. Lewis, Autor ; Evangelos Vassos, Autor . - 2023 . - pp. 800-806. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 800-806 Palabras clave: Genética - Genómica, Puntuaciones poligénicas, Factores de Riesgo Ambiental Resumen: The hypothesis that multiple genetic variants contribute to psychiatric disorders was first proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic contribution of genetic variants, which leads to a continuous liability disease, arose long before molecular genetic studies allowed us to identify specific genetic markers associated with mental disorders. Link: ./index.php?lvl=notice_display&id=29763

Defining recovery from alcohol use disorder / Brett T. Hagman en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 11 (Noviembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 807-813 Título : Defining recovery from alcohol use disorder : development of an niaaa research definition Tipo de documento: texto impreso Autores: Brett T. Hagman, Autor ; Daniel Falk, Autor ; Litten Litten, Autor Fecha de publicación: 2023 Artículo en la página: pp. 807-813 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos adictivos y relacionados con sustancias, Trastorno por consumo de alcohol, Recuperación, DSM-5 Resumen: The objective of this article is to provide an operational definition of recovery from alcohol use disorder (AUD) to facilitate the consistency of research on recovery and stimulate further research. The construct of recovery has been difficult to operationalize in the alcohol treatment and recovery literature. Link: ./index.php?lvl=notice_display&id=29764 [artículo] Defining recovery from alcohol use disorder : development of an niaaa research definition [texto impreso] / Brett T. Hagman, Autor ; Daniel Falk, Autor ; Litten Litten, Autor . - 2023 . - pp. 807-813. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 807-813 Palabras clave: Trastornos adictivos y relacionados con sustancias, Trastorno por consumo de alcohol, Recuperación, DSM-5 Resumen: The objective of this article is to provide an operational definition of recovery from alcohol use disorder (AUD) to facilitate the consistency of research on recovery and stimulate further research. The construct of recovery has been difficult to operationalize in the alcohol treatment and recovery literature. Link: ./index.php?lvl=notice_display&id=29764

Leveraging large scale genetics of ptsd and cardiovascular disease to demonstrate robust shared risk and improve risk prediction accuracy / Antonia V. Seligowski en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 11 (Noviembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 814-823 Título : Leveraging large scale genetics of ptsd and cardiovascular disease to demonstrate robust shared risk and improve risk prediction accuracy Tipo de documento: texto impreso Autores: Antonia V. Seligowski, Autor ; Burook Misganaw, Autor ; Lucie A. Duffy, Autor Fecha de publicación: 2023 Artículo en la página: pp. 814-823 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno de estrés postraumático (TEPT), Enfermedad cardiovascular, Genética - Genómica, Trastornos depresivos, Trastorno depresivo mayor Resumen: Individuals with posttraumatic stress disorder (PTSD) are significantly more likely to be diagnosed with cardiovascular disease (CVD) (e.g., myocardial infarction, stroke). The evidence for this link is so compelling that the National Institutes of Health convened a working group to determine gaps in the literature, including the need for large-scale genomic studies to identify shared genetic risk. Link: ./index.php?lvl=notice_display&id=29765 [artículo] Leveraging large scale genetics of ptsd and cardiovascular disease to demonstrate robust shared risk and improve risk prediction accuracy [texto impreso] / Antonia V. Seligowski, Autor ; Burook Misganaw, Autor ; Lucie A. Duffy, Autor . - 2023 . - pp. 814-823. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 814-823 Palabras clave: Trastorno de estrés postraumático (TEPT), Enfermedad cardiovascular, Genética - Genómica, Trastornos depresivos, Trastorno depresivo mayor Resumen: Individuals with posttraumatic stress disorder (PTSD) are significantly more likely to be diagnosed with cardiovascular disease (CVD) (e.g., myocardial infarction, stroke). The evidence for this link is so compelling that the National Institutes of Health convened a working group to determine gaps in the literature, including the need for large-scale genomic studies to identify shared genetic risk. Link: ./index.php?lvl=notice_display&id=29765

Genetic and environmental contribution to the co-occurrence of endocrine metabolic disorders and depression / Marica Leone en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 11 (Noviembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 824-832 Título : Genetic and environmental contribution to the co-occurrence of endocrine metabolic disorders and depression : a nationwide swedish study of siblings Tipo de documento: texto impreso Autores: Marica Leone, Autor ; Ralf Kuja-Halkola, Autor ; Amy Leval, Autor Fecha de publicación: 2023 Artículo en la página: pp. 824-832 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos Depresivos, Metabolismo Resumen: Depression is common in individuals with endocrine-metabolic disorders and vice versa, and a better understanding of the underlying factors contributing to the comorbidity of these disorders is needed. This study investigated the familial coaggregation of depression and endocrine-metabolic disorders and estimated the contribution of genetic and environmental factors to their co-occurrence. Link: ./index.php?lvl=notice_display&id=29766 [artículo] Genetic and environmental contribution to the co-occurrence of endocrine metabolic disorders and depression : a nationwide swedish study of siblings [texto impreso] / Marica Leone, Autor ; Ralf Kuja-Halkola, Autor ; Amy Leval, Autor . - 2023 . - pp. 824-832. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 824-832 Palabras clave: Trastornos Depresivos, Metabolismo Resumen: Depression is common in individuals with endocrine-metabolic disorders and vice versa, and a better understanding of the underlying factors contributing to the comorbidity of these disorders is needed. This study investigated the familial coaggregation of depression and endocrine-metabolic disorders and estimated the contribution of genetic and environmental factors to their co-occurrence. Link: ./index.php?lvl=notice_display&id=29766

Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation / Guy Hindley en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 11 (Noviembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 833-843 Título : Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation Tipo de documento: texto impreso Autores: Guy Hindley, Autor ; Oleksandr Frei, Autor ; Alexey A. Shadrin, Autor Fecha de publicación: 2023 Artículo en la página: pp. 833-843 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Genética - Genómica, Trastornos bipolares y relacionados, Trastornos depresivos, Trastornos del neurodesarrollo, Trastorno por déficit de atención con hiperactividad (TDAH), Espectro de esquizofrenia y otros trastornos psicóticos Resumen: Mental disorders are heritable and polygenic, and genome-wide genetic correlations (rg) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, rg may underestimate the shared genetic underpinnings of mental disorders and related traits because it does not differentiate mixtures of concordant and discordant genetic effects from an absence of genetic overlap. Link: ./index.php?lvl=notice_display&id=29767 [artículo] Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation [texto impreso] / Guy Hindley, Autor ; Oleksandr Frei, Autor ; Alexey A. Shadrin, Autor . - 2023 . - pp. 833-843. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 833-843 Palabras clave: Genética - Genómica, Trastornos bipolares y relacionados, Trastornos depresivos, Trastornos del neurodesarrollo, Trastorno por déficit de atención con hiperactividad (TDAH), Espectro de esquizofrenia y otros trastornos psicóticos Resumen: Mental disorders are heritable and polygenic, and genome-wide genetic correlations (rg) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, rg may underestimate the shared genetic underpinnings of mental disorders and related traits because it does not differentiate mixtures of concordant and discordant genetic effects from an absence of genetic overlap. Link: ./index.php?lvl=notice_display&id=29767

Association between polygenic risk scores and outcome of ect / Robert Sigström en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 11 (Noviembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 844-852 Título : Association between polygenic risk scores and outcome of ect Tipo de documento: texto impreso Autores: Robert Sigström, Autor ; Kaarina Kowalec, Autor ; Lina Jonsson, Autor Fecha de publicación: 2023 Artículo en la página: pp. 844-852 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Terapia electroconvulsiva (TEC), Trastornos depresivos, Trastornos bipolares y relacionados, Genética - Genómica Resumen: Identifying biomarkers associated with response to electroconvulsive therapy (ECT) may aid clinical decisions. The authors examined whether greater polygenic liabilities for major depressive disorder, bipolar disorder, and schizophrenia are associated with improvement following ECT for a major depressive episode. Link: ./index.php?lvl=notice_display&id=29768 [artículo] Association between polygenic risk scores and outcome of ect [texto impreso] / Robert Sigström, Autor ; Kaarina Kowalec, Autor ; Lina Jonsson, Autor . - 2023 . - pp. 844-852. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 844-852 Palabras clave: Terapia electroconvulsiva (TEC), Trastornos depresivos, Trastornos bipolares y relacionados, Genética - Genómica Resumen: Identifying biomarkers associated with response to electroconvulsive therapy (ECT) may aid clinical decisions. The authors examined whether greater polygenic liabilities for major depressive disorder, bipolar disorder, and schizophrenia are associated with improvement following ECT for a major depressive episode. Link: ./index.php?lvl=notice_display&id=29768

Similar rates of deleterious copy number variants in early-onset psychosis and autism spectrum disorder / Catherine A. Brownstein en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 11 (Noviembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 853-861 Título : Similar rates of deleterious copy number variants in early-onset psychosis and autism spectrum disorder Tipo de documento: texto impreso Autores: Catherine A. Brownstein, Autor ; Elise Douard, Autor ; Josephine Mollon, Autor Fecha de publicación: 2023 Artículo en la página: pp. 853-861 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Psicosis, espectro esquizofrénico y otros trastornos psicóticos, Psiquiatría infantil y del adolescente, Genética - Genómica Resumen: Copy number variants (CNVs) are strongly associated with neurodevelopmental and psychotic disorders. Early-onset psychosis (EOP), where symptoms appear before 18 years of age, is thought to be more strongly influenced by genetic factors than adult-onset psychotic disorders. However, the prevalence and effect of CNVs in EOP is unclear. Link: ./index.php?lvl=notice_display&id=29769 [artículo] Similar rates of deleterious copy number variants in early-onset psychosis and autism spectrum disorder [texto impreso] / Catherine A. Brownstein, Autor ; Elise Douard, Autor ; Josephine Mollon, Autor . - 2023 . - pp. 853-861. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 853-861 Palabras clave: Psicosis, espectro esquizofrénico y otros trastornos psicóticos, Psiquiatría infantil y del adolescente, Genética - Genómica Resumen: Copy number variants (CNVs) are strongly associated with neurodevelopmental and psychotic disorders. Early-onset psychosis (EOP), where symptoms appear before 18 years of age, is thought to be more strongly influenced by genetic factors than adult-onset psychotic disorders. However, the prevalence and effect of CNVs in EOP is unclear. Link: ./index.php?lvl=notice_display&id=29769