Artículos

Pharmacotherapies for treatment-resistant depression / Manish K. Jha en The American Journal of Psychiatry, Año 2023 - Vol. 180 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 190-199 Título : Pharmacotherapies for treatment-resistant depression : how antipsychotics fit in the rapidly evolving therapeutic landscape Tipo de documento: texto impreso Autores: Manish K. Jha, Autor ; Sanjay J. Mathew, Autor Fecha de publicación: 2023 Artículo en la página: pp. 190-199 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Depresión resistente al tratamiento (TRD), Antipsicóticos atípicos, Ketamina, Esketamina, Psicodélicos, Antidepresivos, Trastornos depresivos Resumen: One in three adults with major depressive disorder (MDD) do not experience clinically significant improvement after multiple sequential courses of antidepressants and have treatment-resistant depression (TRD). The presence of TRD contributes to the morbidity and excess mortality associated with MDD and has been linked to significantly increased health care expenses. In the absence of a consensus definition of TRD, this report takes a broad approach by considering inadequate response to one or more courses of antidepressants and focuses on atypical antipsychotics that are approved by the U.S. Link: ./index.php?lvl=notice_display&id=29971 [artículo] Pharmacotherapies for treatment-resistant depression : how antipsychotics fit in the rapidly evolving therapeutic landscape [texto impreso] / Manish K. Jha, Autor ; Sanjay J. Mathew, Autor . - 2023 . - pp. 190-199. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 190-199 Palabras clave: Depresión resistente al tratamiento (TRD), Antipsicóticos atípicos, Ketamina, Esketamina, Psicodélicos, Antidepresivos, Trastornos depresivos Resumen: One in three adults with major depressive disorder (MDD) do not experience clinically significant improvement after multiple sequential courses of antidepressants and have treatment-resistant depression (TRD). The presence of TRD contributes to the morbidity and excess mortality associated with MDD and has been linked to significantly increased health care expenses. In the absence of a consensus definition of TRD, this report takes a broad approach by considering inadequate response to one or more courses of antidepressants and focuses on atypical antipsychotics that are approved by the U.S. Link: ./index.php?lvl=notice_display&id=29971

Polygenic risk and episode polarity among individuals with bipolar disorder / Sofie Hasseris en The American Journal of Psychiatry, Año 2023 - Vol. 180 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 200-208 Título : Polygenic risk and episode polarity among individuals with bipolar disorder Tipo de documento: texto impreso Autores: Sofie Hasseris, Autor ; Clara Albiñana, Autor ; Bjarni J. Vilhjalmsson, Autor Fecha de publicación: 2023 Artículo en la página: pp. 200-208 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos bipolares y relacionados, Genética-Genómica, Riesgo poligénico Resumen: The authors investigated associations between polygenic liabilities for bipolar disorder, major depression, and schizophrenia and episode polarity among individuals with bipolar disorder. Link: ./index.php?lvl=notice_display&id=29972 [artículo] Polygenic risk and episode polarity among individuals with bipolar disorder [texto impreso] / Sofie Hasseris, Autor ; Clara Albiñana, Autor ; Bjarni J. Vilhjalmsson, Autor . - 2023 . - pp. 200-208. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 200-208 Palabras clave: Trastornos bipolares y relacionados, Genética-Genómica, Riesgo poligénico Resumen: The authors investigated associations between polygenic liabilities for bipolar disorder, major depression, and schizophrenia and episode polarity among individuals with bipolar disorder. Link: ./index.php?lvl=notice_display&id=29972

Moderate alcohol consumption and depression / Rachel Visontay en The American Journal of Psychiatry, Año 2023 - Vol. 180 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 209-217 Título : Moderate alcohol consumption and depression : a marginal structural model approach promoting causal inference Tipo de documento: texto impreso Autores: Rachel Visontay, Autor ; Louise Mewton, Autor ; Tim Slade, Autor Fecha de publicación: 2023 Artículo en la página: pp. 209-217 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos depresivos, Trastornos adictivos y relacionados con sustancias, Alcohol, Epidemiología Resumen: Moderate alcohol consumption is associated with decreased risk for depression, but it remains unclear whether this is a causal relationship or a methodological artifact. To compare the effects of consistent abstinence and occasional, moderate, and above-guideline alcohol consumption throughout early to middle adulthood on depression at age 50, the authors conducted a secondary analysis of the National Longitudinal Survey of Youth 1979 cohort and employed a marginal structural model (MSM) approach. Link: ./index.php?lvl=notice_display&id=29973 [artículo] Moderate alcohol consumption and depression : a marginal structural model approach promoting causal inference [texto impreso] / Rachel Visontay, Autor ; Louise Mewton, Autor ; Tim Slade, Autor . - 2023 . - pp. 209-217. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 209-217 Palabras clave: Trastornos depresivos, Trastornos adictivos y relacionados con sustancias, Alcohol, Epidemiología Resumen: Moderate alcohol consumption is associated with decreased risk for depression, but it remains unclear whether this is a causal relationship or a methodological artifact. To compare the effects of consistent abstinence and occasional, moderate, and above-guideline alcohol consumption throughout early to middle adulthood on depression at age 50, the authors conducted a secondary analysis of the National Longitudinal Survey of Youth 1979 cohort and employed a marginal structural model (MSM) approach. Link: ./index.php?lvl=notice_display&id=29973

Shared and unique changes in brain connectivity among depressed patients after remission with pharmacotherapy versus psychotherapy / Boadie W. Dunlop en The American Journal of Psychiatry, Año 2023 - Vol. 180 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 218-229 Título : Shared and unique changes in brain connectivity among depressed patients after remission with pharmacotherapy versus psychotherapy Tipo de documento: texto impreso Autores: Boadie W. Dunlop, Autor ; Jungho Cha, Autor ; Ki Sueng Choi, Autor Fecha de publicación: 2023 Artículo en la página: pp. 218-229 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Trastornos depresivos, Trastorno depresivo mayor, Psicoterapia, Terapia de conducta cognitiva, Marcadores biológicos Resumen: The authors sought to determine the shared and unique changes in brain resting-state functional connectivity (rsFC) between patients with major depressive disorder who achieved remission with cognitive-behavioral therapy (CBT) or with antidepressant medication. Link: ./index.php?lvl=notice_display&id=29974 [artículo] Shared and unique changes in brain connectivity among depressed patients after remission with pharmacotherapy versus psychotherapy [texto impreso] / Boadie W. Dunlop, Autor ; Jungho Cha, Autor ; Ki Sueng Choi, Autor . - 2023 . - pp. 218-229. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 218-229 Palabras clave: Antidepresivos, Trastornos depresivos, Trastorno depresivo mayor, Psicoterapia, Terapia de conducta cognitiva, Marcadores biológicos Resumen: The authors sought to determine the shared and unique changes in brain resting-state functional connectivity (rsFC) between patients with major depressive disorder who achieved remission with cognitive-behavioral therapy (CBT) or with antidepressant medication. Link: ./index.php?lvl=notice_display&id=29974

Functional connectivity mapping for rtms target selection in depression / Immanuel G. Elbau en The American Journal of Psychiatry, Año 2023 - Vol. 180 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 230-240 Título : Functional connectivity mapping for rtms target selection in depression Tipo de documento: texto impreso Autores: Immanuel G. Elbau, Autor ; Charles J. Lynch, Autor ; Jonathan H. Downar, Autor Fecha de publicación: 2023 Artículo en la página: pp. 230-240 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Estimulación magnética transcraneal, Conectividad funcional, Neuroestimulación, Corteza cingulada anterior subgenual, Trastorno depresivo mayor, Neuroimagen Resumen: Repetitive transcranial magnetic stimulation (rTMS) protocols increasingly use subgenual anterior cingulate cortex (sgACC) functional connectivity to individualize treatment targets. However, the efficacy of this approach is unclear, with conflicting findings and varying effect sizes across studies. Here, the authors investigated the effect of the stimulation site’s functional connectivity with the sgACC (sgACC-StimFC) on treatment outcome to rTMS in 295 patients with major depression. Link: ./index.php?lvl=notice_display&id=29975 [artículo] Functional connectivity mapping for rtms target selection in depression [texto impreso] / Immanuel G. Elbau, Autor ; Charles J. Lynch, Autor ; Jonathan H. Downar, Autor . - 2023 . - pp. 230-240. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 230-240 Palabras clave: Estimulación magnética transcraneal, Conectividad funcional, Neuroestimulación, Corteza cingulada anterior subgenual, Trastorno depresivo mayor, Neuroimagen Resumen: Repetitive transcranial magnetic stimulation (rTMS) protocols increasingly use subgenual anterior cingulate cortex (sgACC) functional connectivity to individualize treatment targets. However, the efficacy of this approach is unclear, with conflicting findings and varying effect sizes across studies. Here, the authors investigated the effect of the stimulation site’s functional connectivity with the sgACC (sgACC-StimFC) on treatment outcome to rTMS in 295 patients with major depression. Link: ./index.php?lvl=notice_display&id=29975

Adjunctive cariprazine for the treatment of patients with major depressive disorder / Gary S. Sachs en The American Journal of Psychiatry, Año 2023 - Vol. 180 - No. 3 (Marzo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 241-251 Título : Adjunctive cariprazine for the treatment of patients with major depressive disorder : a randomized, double-blind, placebo-controlled phase 3 study Tipo de documento: texto impreso Autores: Gary S. Sachs, Autor ; Paul P. Yeung, Autor ; Ludmyla Rekeda, Autor Fecha de publicación: 2023 Artículo en la página: pp. 241-251 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Tratamiento adyuvante, cariprazina, Trastorno depresivo mayor, Ensayo controlado aleatorizado, Estudios clínicos de fármacos Resumen: The purpose of this study was to investigate the efficacy of cariprazine, a dopamine D3-preferring D3/D2 and serotonin 5-HT1A receptor partial agonist, as adjunctive therapy for patients with major depressive disorder and nonresponse to at least one antidepressant monotherapy. Link: ./index.php?lvl=notice_display&id=29976 [artículo] Adjunctive cariprazine for the treatment of patients with major depressive disorder : a randomized, double-blind, placebo-controlled phase 3 study [texto impreso] / Gary S. Sachs, Autor ; Paul P. Yeung, Autor ; Ludmyla Rekeda, Autor . - 2023 . - pp. 241-251. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2023 - Vol. 180 - No. 3 (Marzo) . - pp. 241-251 Palabras clave: Tratamiento adyuvante, cariprazina, Trastorno depresivo mayor, Ensayo controlado aleatorizado, Estudios clínicos de fármacos Resumen: The purpose of this study was to investigate the efficacy of cariprazine, a dopamine D3-preferring D3/D2 and serotonin 5-HT1A receptor partial agonist, as adjunctive therapy for patients with major depressive disorder and nonresponse to at least one antidepressant monotherapy. Link: ./index.php?lvl=notice_display&id=29976