Artículos

A new approach to rater training and certification in a multicenter clinical trial / Kenneth Kobak en Journal of Clinical Psychopharmacology, Año 2005 - Vol. 25 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 407-412 Título : A new approach to rater training and certification in a multicenter clinical trial Tipo de documento: texto impreso Autores: Kenneth Kobak, Autor ; Joshua D. Lipsitz, Autor ; Janet B. W. Williams, Autor Fecha de publicación: 2023 Artículo en la página: pp. 407-412 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Competencia clínica, Ensayos clínicos como tema, Trastorno depresivo, Personal de investigación - educación Resumen: Recent evidence demonstrates that the quality of raters' applied clinical skills is directly related to study outcome. As such, the training and evaluation of raters' clinical skill in administering symptom-rating scales is essential before being certified to rate patients in clinical trials. Link: ./index.php?lvl=notice_display&id=30884 [artículo] A new approach to rater training and certification in a multicenter clinical trial [texto impreso] / Kenneth Kobak, Autor ; Joshua D. Lipsitz, Autor ; Janet B. W. Williams, Autor . - 2023 . - pp. 407-412. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 407-412 Palabras clave: Antidepresivos, Competencia clínica, Ensayos clínicos como tema, Trastorno depresivo, Personal de investigación - educación Resumen: Recent evidence demonstrates that the quality of raters' applied clinical skills is directly related to study outcome. As such, the training and evaluation of raters' clinical skill in administering symptom-rating scales is essential before being certified to rate patients in clinical trials. Link: ./index.php?lvl=notice_display&id=30884

A comparison of the effects of olanzapine and risperidone versus placebo on eating behaviors / James L. Roerig en Journal of Clinical Psychopharmacology, Año 2005 - Vol. 25 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 413-418 Título : A comparison of the effects of olanzapine and risperidone versus placebo on eating behaviors Tipo de documento: texto impreso Autores: James L. Roerig, Autor ; James E. Mitchell, Autor ; Martina de Zwaan, Autor Fecha de publicación: 2023 Artículo en la página: pp. 413-418 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Benzodiazepinas, Ingesta de energía, Comportamiento alimentario, Olanzapina, Risperidona. Resumen: To thoroughly investigate the phenomenon of atypical antipsychotic associated weight gain, a feeding laboratory paradigm was developed. This study is a randomized, double-blind, parallel group trial comparing the tolerability and effects of a two-week exposure to olanzapine, risperidone or placebo on weight, resting energy expenditure (REE), and eating behaviors in 48 healthy human subjects. Link: ./index.php?lvl=notice_display&id=30885 [artículo] A comparison of the effects of olanzapine and risperidone versus placebo on eating behaviors [texto impreso] / James L. Roerig, Autor ; James E. Mitchell, Autor ; Martina de Zwaan, Autor . - 2023 . - pp. 413-418. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 413-418 Palabras clave: Antipsicóticos, Benzodiazepinas, Ingesta de energía, Comportamiento alimentario, Olanzapina, Risperidona. Resumen: To thoroughly investigate the phenomenon of atypical antipsychotic associated weight gain, a feeding laboratory paradigm was developed. This study is a randomized, double-blind, parallel group trial comparing the tolerability and effects of a two-week exposure to olanzapine, risperidone or placebo on weight, resting energy expenditure (REE), and eating behaviors in 48 healthy human subjects. Link: ./index.php?lvl=notice_display&id=30885

Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients / Karin Fehsel en Journal of Clinical Psychopharmacology, Año 2005 - Vol. 25 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 419-426 Título : Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients Tipo de documento: texto impreso Autores: Karin Fehsel, Autor ; Stefan Loeffler, Autor ; Klaus Krieger, Autor Fecha de publicación: 2023 Artículo en la página: pp. 419-426 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Apoptosis, Clozapina, Expresión genética, Genes, Técnicas In Vitro, Leucocitos, Neutrófilos, Estrés oxidativo, Esquizofrenia. Resumen: The present study examined cellular effects of the atypical antipsychotic drug clozapine on blood cells of treated patients with and without clozapine-induced agranulocytosis (CA). Blood from one patient who commenced clozapine treatment was examined at weekly intervals for 128 days. Olanzapine-treated (n = 5) and polymedicated (n = 14) schizophrenic patients, as well as healthy subjects (n = 19) and septic shock patients (n = 8), were studied for comparison. Link: ./index.php?lvl=notice_display&id=30886 [artículo] Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients [texto impreso] / Karin Fehsel, Autor ; Stefan Loeffler, Autor ; Klaus Krieger, Autor . - 2023 . - pp. 419-426. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 419-426 Palabras clave: Antipsicóticos, Apoptosis, Clozapina, Expresión genética, Genes, Técnicas In Vitro, Leucocitos, Neutrófilos, Estrés oxidativo, Esquizofrenia. Resumen: The present study examined cellular effects of the atypical antipsychotic drug clozapine on blood cells of treated patients with and without clozapine-induced agranulocytosis (CA). Blood from one patient who commenced clozapine treatment was examined at weekly intervals for 128 days. Olanzapine-treated (n = 5) and polymedicated (n = 14) schizophrenic patients, as well as healthy subjects (n = 19) and septic shock patients (n = 8), were studied for comparison. Link: ./index.php?lvl=notice_display&id=30886

Pharmacogenetic testing in the clinical management of schizophrenia / Roy H. Perlis en Journal of Clinical Psychopharmacology, Año 2005 - Vol. 25 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 427-434 Título : Pharmacogenetic testing in the clinical management of schizophrenia : A decision-analytic model Tipo de documento: texto impreso Autores: Roy H. Perlis, Autor ; David A. Ganz, Autor ; Jerry Avorn, Autor Fecha de publicación: 2023 Artículo en la página: pp. 427-434 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Clozapina, Farmacogenética, Calidad de vida, Esquizofrenia. Resumen: Clinical application of pharmacogenetic testing has been proposed as a means of improving treatment outcomes in psychiatry. The identification of a putative genetic test for better clozapine response in schizophrenia offers an opportunity to evaluate the cost-effectiveness of such testing. Link: ./index.php?lvl=notice_display&id=30887 [artículo] Pharmacogenetic testing in the clinical management of schizophrenia : A decision-analytic model [texto impreso] / Roy H. Perlis, Autor ; David A. Ganz, Autor ; Jerry Avorn, Autor . - 2023 . - pp. 427-434. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 427-434 Palabras clave: Antipsicóticos, Clozapina, Farmacogenética, Calidad de vida, Esquizofrenia. Resumen: Clinical application of pharmacogenetic testing has been proposed as a means of improving treatment outcomes in psychiatry. The identification of a putative genetic test for better clozapine response in schizophrenia offers an opportunity to evaluate the cost-effectiveness of such testing. Link: ./index.php?lvl=notice_display&id=30887

Drug-induced agranulocytosis: Impact of different fcγ receptor polymorphisms? / Igor Mosyagin en Journal of Clinical Psychopharmacology, Año 2005 - Vol. 25 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 435-440 Título : Drug-induced agranulocytosis: Impact of different fcγ receptor polymorphisms? Tipo de documento: texto impreso Autores: Igor Mosyagin, Autor ; Ingolf Cascorbi, Autor ; Rainer Schaub, Autor Fecha de publicación: 2023 Artículo en la página: pp. 435-440 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Agranulocitosis, Agentes antipsicóticos, Agentes antitiroideos, Clozapina, Agentes fibrinolíticos, Receptores. Resumen: Drug-induced agranulocytosis is a rare but life-threatening side effect which is possibly based on immunogenetic mechanisms. Some studies regarding agranulocytosis induced by the atypical antipsychotic clozapine dealing with HLA subtyping and enzyme polymorphisms have been performed to elucidate its genetic background. Link: ./index.php?lvl=notice_display&id=30888 [artículo] Drug-induced agranulocytosis: Impact of different fcγ receptor polymorphisms? [texto impreso] / Igor Mosyagin, Autor ; Ingolf Cascorbi, Autor ; Rainer Schaub, Autor . - 2023 . - pp. 435-440. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 435-440 Palabras clave: Agranulocitosis, Agentes antipsicóticos, Agentes antitiroideos, Clozapina, Agentes fibrinolíticos, Receptores. Resumen: Drug-induced agranulocytosis is a rare but life-threatening side effect which is possibly based on immunogenetic mechanisms. Some studies regarding agranulocytosis induced by the atypical antipsychotic clozapine dealing with HLA subtyping and enzyme polymorphisms have been performed to elucidate its genetic background. Link: ./index.php?lvl=notice_display&id=30888

A double-blind, randomized trial of st john's wort, fluoxetine, and placebo in major depressive disorder / Maurizio Fava en Journal of Clinical Psychopharmacology, Año 2005 - Vol. 25 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 441-447 Título : A double-blind, randomized trial of st john's wort, fluoxetine, and placebo in major depressive disorder Tipo de documento: texto impreso Autores: Maurizio Fava, Autor ; Jonathan E. Alpert, Autor ; Andrew A. Nierenberg, Autor Fecha de publicación: 2023 Artículo en la página: pp. 441-447 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Trastorno depresivo mayor, Fluoxetina, Fitoterapia. Resumen: This study looks to compare the antidepressant efficacy and safety of a standardized extract of St John's wort with both placebo and fluoxetine. Link: ./index.php?lvl=notice_display&id=30889 [artículo] A double-blind, randomized trial of st john's wort, fluoxetine, and placebo in major depressive disorder [texto impreso] / Maurizio Fava, Autor ; Jonathan E. Alpert, Autor ; Andrew A. Nierenberg, Autor . - 2023 . - pp. 441-447. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 441-447 Palabras clave: Antidepresivos, Trastorno depresivo mayor, Fluoxetina, Fitoterapia. Resumen: This study looks to compare the antidepressant efficacy and safety of a standardized extract of St John's wort with both placebo and fluoxetine. Link: ./index.php?lvl=notice_display&id=30889

Polymorphic variations in gstm1, gstt1, pgp, cyp2d6, cyp3a5, and dopamine d2 and d3 receptors and their association with tardive dyskinesia in severe mental illness / Jose de Leon en Journal of Clinical Psychopharmacology, Año 2005 - Vol. 25 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 448-456 Título : Polymorphic variations in gstm1, gstt1, pgp, cyp2d6, cyp3a5, and dopamine d2 and d3 receptors and their association with tardive dyskinesia in severe mental illness Tipo de documento: texto impreso Autores: Jose de Leon, Autor ; Margaret T. Susce, Autor ; Run Mei Pan, Autor Fecha de publicación: 2023 Artículo en la página: pp. 448-456 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Discinesia inducida por fármacos, Trastornos mentales, Farmacogenética, Trastornos psicóticos, Risperidona. Resumen: This study tested the association between tardive dyskinesia (TD) and polymorphic variations in (a) 2 cytochrome P450 (CYP) genes (CYP2D6 or CYP3A5), (b) 2 DRD2 variants (Ser311Cys and -141C Ins/del) and the Ser9Gly DRD3 variants, (c) 2 glutathione S-transferases (GSTT1 and GSTM1), and (d) variations in the PgP gene, MDR1. Link: ./index.php?lvl=notice_display&id=30890 [artículo] Polymorphic variations in gstm1, gstt1, pgp, cyp2d6, cyp3a5, and dopamine d2 and d3 receptors and their association with tardive dyskinesia in severe mental illness [texto impreso] / Jose de Leon, Autor ; Margaret T. Susce, Autor ; Run Mei Pan, Autor . - 2023 . - pp. 448-456. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 448-456 Palabras clave: Antipsicóticos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Discinesia inducida por fármacos, Trastornos mentales, Farmacogenética, Trastornos psicóticos, Risperidona. Resumen: This study tested the association between tardive dyskinesia (TD) and polymorphic variations in (a) 2 cytochrome P450 (CYP) genes (CYP2D6 or CYP3A5), (b) 2 DRD2 variants (Ser311Cys and -141C Ins/del) and the Ser9Gly DRD3 variants, (c) 2 glutathione S-transferases (GSTT1 and GSTM1), and (d) variations in the PgP gene, MDR1. Link: ./index.php?lvl=notice_display&id=30890

Is the prophylactic antidepressant efficacy of lithium in bipolar i disorder dependent on study design and lithium level? / Wolfram Emanuel Severus en Journal of Clinical Psychopharmacology, Año 2005 - Vol. 25 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 457-462 Título : Is the prophylactic antidepressant efficacy of lithium in bipolar i disorder dependent on study design and lithium level? Tipo de documento: texto impreso Autores: Wolfram Emanuel Severus, Autor ; Heinz Grunze, Autor ; Nikolaus Kleindienst, Autor Fecha de publicación: 2023 Artículo en la página: pp. 457-462 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antimaníacos, Trastorno Bipolar, Litio, Diseño de la investigación Resumen: In the 1970s, several randomized controlled trials demonstrated significant antimanic and antidepressant properties of lithium in the prophylactic treatment of bipolar disorder. However, a recent meta-analysis of randomized, placebo-controlled trials of lithium in bipolar disorder found that its protective effect against depressive relapse/recurrence was equivocal. Link: ./index.php?lvl=notice_display&id=30891 [artículo] Is the prophylactic antidepressant efficacy of lithium in bipolar i disorder dependent on study design and lithium level? [texto impreso] / Wolfram Emanuel Severus, Autor ; Heinz Grunze, Autor ; Nikolaus Kleindienst, Autor . - 2023 . - pp. 457-462. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 457-462 Palabras clave: Antimaníacos, Trastorno Bipolar, Litio, Diseño de la investigación Resumen: In the 1970s, several randomized controlled trials demonstrated significant antimanic and antidepressant properties of lithium in the prophylactic treatment of bipolar disorder. However, a recent meta-analysis of randomized, placebo-controlled trials of lithium in bipolar disorder found that its protective effect against depressive relapse/recurrence was equivocal. Link: ./index.php?lvl=notice_display&id=30891