[artículo]
| Título : |
A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition |
| Tipo de documento: |
texto impreso |
| Autores: |
Edmund P. Harrigan, Autor ; Jeffrey J. Miceli, Autor ; Richard Anziano, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 62-69 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Antipsicóticos, Aril Hidrocarburo Hidroxilasas, Benzodiazepinas, Clozapina, Dibenzotiazepinas, Electrocardiografía, Haloperidol, Sistema de conducción del corazón, Síndrome de QT largo, Olanzapina, Fumarato de quetiapina, Risperidona, Tioridazina. |
| Resumen: |
Many drugs have been associated with QTc prolongation and, in some cases, this is augmented by concomitant administration with metabolic inhibitors. The effects of 6 antipsychotics on the QTc interval at and around the time of estimated peak plasma/serum concentrations in the absence and presence of metabolic inhibition were characterized in a prospective, randomized study in which patients with psychotic disorders reached steady-state on either haloperidol 15 mg/d (n = 27), thioridazine 300 mg/d (n = 30), ziprasidone 160 mg/d (n = 31), quetiapine 750 mg/d (n = 27), olanzapine 20 mg/d (n = 24), or risperidone 6-8 mg/d increased to 16 mg/d (n = 25/20). |
| Link: |
./index.php?lvl=notice_display&id=30980 |
in Journal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 1 (Febrero) . - pp. 62-69
[artículo] A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition [texto impreso] / Edmund P. Harrigan, Autor ; Jeffrey J. Miceli, Autor ; Richard Anziano, Autor . - 2023 . - pp. 62-69. Idioma : Inglés ( eng) Idioma original : Inglés ( eng) in Journal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 1 (Febrero) . - pp. 62-69
| Palabras clave: |
Antipsicóticos, Aril Hidrocarburo Hidroxilasas, Benzodiazepinas, Clozapina, Dibenzotiazepinas, Electrocardiografía, Haloperidol, Sistema de conducción del corazón, Síndrome de QT largo, Olanzapina, Fumarato de quetiapina, Risperidona, Tioridazina. |
| Resumen: |
Many drugs have been associated with QTc prolongation and, in some cases, this is augmented by concomitant administration with metabolic inhibitors. The effects of 6 antipsychotics on the QTc interval at and around the time of estimated peak plasma/serum concentrations in the absence and presence of metabolic inhibition were characterized in a prospective, randomized study in which patients with psychotic disorders reached steady-state on either haloperidol 15 mg/d (n = 27), thioridazine 300 mg/d (n = 30), ziprasidone 160 mg/d (n = 31), quetiapine 750 mg/d (n = 27), olanzapine 20 mg/d (n = 24), or risperidone 6-8 mg/d increased to 16 mg/d (n = 25/20). |
| Link: |
./index.php?lvl=notice_display&id=30980 |
|
Añadir el resultado a su cestaComparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers en Journal of Clinical Psychopharmacology, Año 2004 - Vol. 24 - No. 1 (Febrero)
