Artículos

Catechol-o-methyltransferase and monoamine oxidase a genotypes and drug response to conventional neuroleptics in schizophrenia / Ari Illi en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 429-434 Título : Catechol-o-methyltransferase and monoamine oxidase a genotypes and drug response to conventional neuroleptics in schizophrenia Tipo de documento: texto impreso Autores: Ari Illi, Autor ; Kari M. Mattila, Autor ; Olli Kampman, Autor Fecha de publicación: 2023 Artículo en la página: pp. 429-434 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Monoaminooxidasa, Esquizofrenia - farmacoterapia. Resumen: Biogenic amine synthesis and degradation are involved in the pathogenesis of schizophrenia. Catechol-O-methyltransferase and monoamine oxidase enzymes are important agents in the metabolic inactivation of these neurotransmitters (ie, dopamine, serotonin, and norepinephrine). Functional polymorphism in the catechol-O-methyltransferase and monoamine oxidase A genes causes variation in enzyme activities. Link: ./index.php?lvl=notice_display&id=30994 [artículo] Catechol-o-methyltransferase and monoamine oxidase a genotypes and drug response to conventional neuroleptics in schizophrenia [texto impreso] / Ari Illi, Autor ; Kari M. Mattila, Autor ; Olli Kampman, Autor . - 2023 . - pp. 429-434. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 429-434 Palabras clave: Antipsicóticos, Monoaminooxidasa, Esquizofrenia - farmacoterapia. Resumen: Biogenic amine synthesis and degradation are involved in the pathogenesis of schizophrenia. Catechol-O-methyltransferase and monoamine oxidase enzymes are important agents in the metabolic inactivation of these neurotransmitters (ie, dopamine, serotonin, and norepinephrine). Functional polymorphism in the catechol-O-methyltransferase and monoamine oxidase A genes causes variation in enzyme activities. Link: ./index.php?lvl=notice_display&id=30994

Significant dose effect of carbamazepine on reduction of steady-state plasma concentration of haloperidol in schizophrenic patients / Norio Yasui Furukori en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 435-440 Título : Significant dose effect of carbamazepine on reduction of steady-state plasma concentration of haloperidol in schizophrenic patients Tipo de documento: texto impreso Autores: Norio Yasui Furukori, Autor ; Tsuyoshi Kondo, Autor ; Kazuo Mihara, Autor Fecha de publicación: 2023 Artículo en la página: pp. 435-440 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Carbamazepina, Relación Dosis-Respuesta, Interacciones farmacológicas, Haloperidol, Esquizofrenia. Resumen: A reduction in haloperidol concentration induced by carbamazepine coadministration has been consistently reported. However, the degree of this reduction is very different among individuals treated with various doses of carbamazepine. Thus, we investigated dose effect of carbamazepine on the steady-state plasma concentration of haloperidol. Link: ./index.php?lvl=notice_display&id=30995 [artículo] Significant dose effect of carbamazepine on reduction of steady-state plasma concentration of haloperidol in schizophrenic patients [texto impreso] / Norio Yasui Furukori, Autor ; Tsuyoshi Kondo, Autor ; Kazuo Mihara, Autor . - 2023 . - pp. 435-440. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 435-440 Palabras clave: Carbamazepina, Relación Dosis-Respuesta, Interacciones farmacológicas, Haloperidol, Esquizofrenia. Resumen: A reduction in haloperidol concentration induced by carbamazepine coadministration has been consistently reported. However, the degree of this reduction is very different among individuals treated with various doses of carbamazepine. Thus, we investigated dose effect of carbamazepine on the steady-state plasma concentration of haloperidol. Link: ./index.php?lvl=notice_display&id=30995

Influences of an anticholinergic antiparkinsonian drug, parkinsonism, and psychotic symptoms on cardiac autonomic function in schizophrenia / Takashi Okada en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 441-447 Título : Influences of an anticholinergic antiparkinsonian drug, parkinsonism, and psychotic symptoms on cardiac autonomic function in schizophrenia Tipo de documento: texto impreso Autores: Takashi Okada, Autor ; Motomi Toichi, Autor ; Morimitsu Sakihama, Autor Fecha de publicación: 2023 Artículo en la página: pp. 441-447 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antiparkinsonianos, Antagonistas colinérgicos, Pruebas de función cardíaca, Trastornos parkinsonianos, Trastornos psicóticos. Resumen: The arguments against the use of anticholinergic antiparkinsonian drugs for neuroleptic-induced parkinsonism have been based, in part, on their autonomic side effects. Except for anecdotal case reports, there is little evidence that antiparkinsonian drugs are the main factor causing autonomic dysfunction in schizophrenic patients with parkinsonism. Link: ./index.php?lvl=notice_display&id=30996 [artículo] Influences of an anticholinergic antiparkinsonian drug, parkinsonism, and psychotic symptoms on cardiac autonomic function in schizophrenia [texto impreso] / Takashi Okada, Autor ; Motomi Toichi, Autor ; Morimitsu Sakihama, Autor . - 2023 . - pp. 441-447. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 441-447 Palabras clave: Antiparkinsonianos, Antagonistas colinérgicos, Pruebas de función cardíaca, Trastornos parkinsonianos, Trastornos psicóticos. Resumen: The arguments against the use of anticholinergic antiparkinsonian drugs for neuroleptic-induced parkinsonism have been based, in part, on their autonomic side effects. Except for anecdotal case reports, there is little evidence that antiparkinsonian drugs are the main factor causing autonomic dysfunction in schizophrenic patients with parkinsonism. Link: ./index.php?lvl=notice_display&id=30996

Lack of efficacy of low doses of quetiapine addition in refractory obsessive-compulsive disorder / Levent Sevincok en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 448-450 Título : Lack of efficacy of low doses of quetiapine addition in refractory obsessive-compulsive disorder Tipo de documento: texto impreso Autores: Levent Sevincok, Autor ; Ayse Topuz, Autor Fecha de publicación: 2023 Artículo en la página: pp. 448-450 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Dibenzotiazepinas, Trastorno obsesivo-compulsivo, Fumarato de quetiapina Resumen: Some studies have shown that low dose of neuroleptic addition to ongoing antiobsessive treatment might be effective in treatment resistant obsessive-compulsive disorder (OCD). The primary purpose of this study was to evaluate the efficacy of low-dose quetiapine in clomipramine and serotonin reuptake inhibitor-refractory obsessive-compulsive disorder patients. Link: ./index.php?lvl=notice_display&id=30997 [artículo] Lack of efficacy of low doses of quetiapine addition in refractory obsessive-compulsive disorder [texto impreso] / Levent Sevincok, Autor ; Ayse Topuz, Autor . - 2023 . - pp. 448-450. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 448-450 Palabras clave: Dibenzotiazepinas, Trastorno obsesivo-compulsivo, Fumarato de quetiapina Resumen: Some studies have shown that low dose of neuroleptic addition to ongoing antiobsessive treatment might be effective in treatment resistant obsessive-compulsive disorder (OCD). The primary purpose of this study was to evaluate the efficacy of low-dose quetiapine in clomipramine and serotonin reuptake inhibitor-refractory obsessive-compulsive disorder patients. Link: ./index.php?lvl=notice_display&id=30997

Thrombocytopenia during valproic acid treatment in young patients with new-onset bipolar disorder / Domenico De Berardis en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 451-458 Título : Thrombocytopenia during valproic acid treatment in young patients with new-onset bipolar disorder Tipo de documento: texto impreso Autores: Domenico De Berardis, Autor ; Daniela Campanella, Autor ; Vincenzo Matera, Autor Fecha de publicación: 2023 Artículo en la página: pp. 451-458 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno bipolar, Distribución normal, Trombocitopenia. Resumen: To evaluate whether valproic acid (VPA) can cause thrombocytopenia and impaired platelet function in young patients with new-onset bipolar disorder. The authors studied 25 new-onset young bipolar patients. Platelet count, platelet aggregation, platelet release, and bleeding time were evaluated before beginning VPA treatment and at least after 10 months of treatment. Link: ./index.php?lvl=notice_display&id=30998 [artículo] Thrombocytopenia during valproic acid treatment in young patients with new-onset bipolar disorder [texto impreso] / Domenico De Berardis, Autor ; Daniela Campanella, Autor ; Vincenzo Matera, Autor . - 2023 . - pp. 451-458. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 451-458 Palabras clave: Trastorno bipolar, Distribución normal, Trombocitopenia. Resumen: To evaluate whether valproic acid (VPA) can cause thrombocytopenia and impaired platelet function in young patients with new-onset bipolar disorder. The authors studied 25 new-onset young bipolar patients. Platelet count, platelet aggregation, platelet release, and bleeding time were evaluated before beginning VPA treatment and at least after 10 months of treatment. Link: ./index.php?lvl=notice_display&id=30998

Effects of polymorphisms in cyp2d6, cyp2c9, and cyp2c19 on trimipramine pharmacokinetics / Julia Kirchheiner en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 459-466 Título : Effects of polymorphisms in cyp2d6, cyp2c9, and cyp2c19 on trimipramine pharmacokinetics Tipo de documento: texto impreso Autores: Julia Kirchheiner, Autor ; Gunnar Müller, Autor ; Ingolf Meineke, Autor Fecha de publicación: 2023 Artículo en la página: pp. 459-466 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Citocromo P-450 CYP2D6, Tasa de aclaramiento metabólico, Oxigenasas de función mixta, Polimorfismo genético. Resumen: Little is known about the impact of cytochrome P450 polymorphisms on the metabolism of trimipramine, which is still widely used as antidepressant due to its positive effect on sleep patterns. Link: ./index.php?lvl=notice_display&id=30999 [artículo] Effects of polymorphisms in cyp2d6, cyp2c9, and cyp2c19 on trimipramine pharmacokinetics [texto impreso] / Julia Kirchheiner, Autor ; Gunnar Müller, Autor ; Ingolf Meineke, Autor . - 2023 . - pp. 459-466. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 459-466 Palabras clave: Citocromo P-450 CYP2D6, Tasa de aclaramiento metabólico, Oxigenasas de función mixta, Polimorfismo genético. Resumen: Little is known about the impact of cytochrome P450 polymorphisms on the metabolism of trimipramine, which is still widely used as antidepressant due to its positive effect on sleep patterns. Link: ./index.php?lvl=notice_display&id=30999

Antidepressants and ejaculation: a double-blind, randomized, fixed-dose study with mirtazapine and paroxetine / Marcel D. Waldinger en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 467-470 Título : Antidepressants and ejaculation: a double-blind, randomized, fixed-dose study with mirtazapine and paroxetine Tipo de documento: texto impreso Autores: Marcel D. Waldinger, Autor ; Aeilko H. Zwinderman, Autor ; Berend Olivier, Autor Fecha de publicación: 2023 Artículo en la página: pp. 467-470 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Eyaculación - efectos del medicamento, Mianserina, Mirtazapina, Paroxetina, Disfunción sexual. Resumen: A double-blind, fixed-dose study in healthy men with lifelong early ejaculation was performed to evaluate potential differences in their effects on ejaculation latency, between clinically relevant doses of the selective serotonin reuptake inhibitor paroxetine and the noradrenergic and specific serotonergic antidepressant mirtazapine. Link: ./index.php?lvl=notice_display&id=31000 [artículo] Antidepressants and ejaculation: a double-blind, randomized, fixed-dose study with mirtazapine and paroxetine [texto impreso] / Marcel D. Waldinger, Autor ; Aeilko H. Zwinderman, Autor ; Berend Olivier, Autor . - 2023 . - pp. 467-470. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 467-470 Palabras clave: Antidepresivos, Eyaculación - efectos del medicamento, Mianserina, Mirtazapina, Paroxetina, Disfunción sexual. Resumen: A double-blind, fixed-dose study in healthy men with lifelong early ejaculation was performed to evaluate potential differences in their effects on ejaculation latency, between clinically relevant doses of the selective serotonin reuptake inhibitor paroxetine and the noradrenergic and specific serotonergic antidepressant mirtazapine. Link: ./index.php?lvl=notice_display&id=31000

Dose-related pharmacokinetics and pharmacodynamics of valproate in the elderly / Susy Felix en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 471-478 Título : Dose-related pharmacokinetics and pharmacodynamics of valproate in the elderly Tipo de documento: texto impreso Autores: Susy Felix, Autor ; Beth A. Sproule, Autor ; Brian G. Hardy, Autor Fecha de publicación: 2023 Artículo en la página: pp. 471-478 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Tasa de aclaramiento metabólico, Ácido Valproico. Resumen: Valproate exhibits a complex pharmacokinetic profile due to concentration-dependent protein binding and clearance. It has been shown that the protein binding of valproate decreases as the serum concentration increases in a young adult population. Furthermore, the percentage of protein binding is lower in the elderly compared with young adults at comparable low therapeutic serum concentrations. Link: ./index.php?lvl=notice_display&id=31001 [artículo] Dose-related pharmacokinetics and pharmacodynamics of valproate in the elderly [texto impreso] / Susy Felix, Autor ; Beth A. Sproule, Autor ; Brian G. Hardy, Autor . - 2023 . - pp. 471-478. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 471-478 Palabras clave: Tasa de aclaramiento metabólico, Ácido Valproico. Resumen: Valproate exhibits a complex pharmacokinetic profile due to concentration-dependent protein binding and clearance. It has been shown that the protein binding of valproate decreases as the serum concentration increases in a young adult population. Furthermore, the percentage of protein binding is lower in the elderly compared with young adults at comparable low therapeutic serum concentrations. Link: ./index.php?lvl=notice_display&id=31001

Hyperprolactinemia in patients on antipsychotic drugs causes adp-stimulated platelet activation that might explain the increased risk for venous thromboembolism: pilot study / Henri Wallaschofski en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 479-483 Título : Hyperprolactinemia in patients on antipsychotic drugs causes adp-stimulated platelet activation that might explain the increased risk for venous thromboembolism: pilot study Tipo de documento: texto impreso Autores: Henri Wallaschofski, Autor ; Martin Eigenthaler, Autor ; Markus Kiefer, Autor Fecha de publicación: 2023 Artículo en la página: pp. 479-483 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Hiperprolactinemia, Activación plaquetaria, Tromboembolismo. Resumen: Recently, an increased risk of venous thromboembolism in patients on antipsychotic drugs has been reported, but the molecular etiology is still unknown. Most antipsychotic drugs act as dopamine antagonists, and some of them cause hyperprolactinemia. Hyperprolactinemia has recently been found to cause increased platelet activation via potentiating ADP effects on human platelets. Link: ./index.php?lvl=notice_display&id=31002 [artículo] Hyperprolactinemia in patients on antipsychotic drugs causes adp-stimulated platelet activation that might explain the increased risk for venous thromboembolism: pilot study [texto impreso] / Henri Wallaschofski, Autor ; Martin Eigenthaler, Autor ; Markus Kiefer, Autor . - 2023 . - pp. 479-483. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 479-483 Palabras clave: Antipsicóticos, Hiperprolactinemia, Activación plaquetaria, Tromboembolismo. Resumen: Recently, an increased risk of venous thromboembolism in patients on antipsychotic drugs has been reported, but the molecular etiology is still unknown. Most antipsychotic drugs act as dopamine antagonists, and some of them cause hyperprolactinemia. Hyperprolactinemia has recently been found to cause increased platelet activation via potentiating ADP effects on human platelets. Link: ./index.php?lvl=notice_display&id=31002

Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders / Terence A. Ketter en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 484-495 Título : Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders Tipo de documento: texto impreso Autores: Terence A. Ketter, Autor ; Husseini K. Manji, Autor ; Robert M. Post, Autor Fecha de publicación: 2023 Artículo en la página: pp. 484-495 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno bipolar, Canales iónicos, lamotrigina, Transducción de señales, Triazinas. Resumen: Based on the mood-stabilizing properties of carbamazepine and valproate, new anticonvulsants have been explored for use in bipolar disorders. One such agent, lamotrigine, has a novel clinical profile in that it may “stabilize mood from below,” as it appears to maximally impact depressive symptoms in bipolar disorders. Link: ./index.php?lvl=notice_display&id=31003 [artículo] Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders [texto impreso] / Terence A. Ketter, Autor ; Husseini K. Manji, Autor ; Robert M. Post, Autor . - 2023 . - pp. 484-495. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 484-495 Palabras clave: Trastorno bipolar, Canales iónicos, lamotrigina, Transducción de señales, Triazinas. Resumen: Based on the mood-stabilizing properties of carbamazepine and valproate, new anticonvulsants have been explored for use in bipolar disorders. One such agent, lamotrigine, has a novel clinical profile in that it may “stabilize mood from below,” as it appears to maximally impact depressive symptoms in bipolar disorders. Link: ./index.php?lvl=notice_display&id=31003