Artículos

Therapeutic tolerance and rebound psychosis during quetiapine maintenance monotherapy in patients with schizophrenia and schizoaffective disorder / Howard C. Margolese en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 347-352 Título : Therapeutic tolerance and rebound psychosis during quetiapine maintenance monotherapy in patients with schizophrenia and schizoaffective disorder Tipo de documento: texto impreso Autores: Howard C. Margolese, Autor ; Guy Chouinard, Autor ; Linda Beauclair, Autor Fecha de publicación: 2023 Artículo en la página: pp. 347-352 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Tolerancia al medicamento, Psicosis inducidas por sustancias, Trastornos psicóticos, Esquizofrenia. Resumen: A 3-year open-label study was conducted to determine the long-term safety and efficacy of quetiapine monotherapy in schizophrenia and schizoaffective disorder. Twenty-three male outpatients previously stable but with inter-episode residual symptoms on classical antipsychotics and/or risperidone and who had complained of side effects were selected. Link: ./index.php?lvl=notice_display&id=31049 [artículo] Therapeutic tolerance and rebound psychosis during quetiapine maintenance monotherapy in patients with schizophrenia and schizoaffective disorder [texto impreso] / Howard C. Margolese, Autor ; Guy Chouinard, Autor ; Linda Beauclair, Autor . - 2023 . - pp. 347-352. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 347-352 Palabras clave: Antipsicóticos, Tolerancia al medicamento, Psicosis inducidas por sustancias, Trastornos psicóticos, Esquizofrenia. Resumen: A 3-year open-label study was conducted to determine the long-term safety and efficacy of quetiapine monotherapy in schizophrenia and schizoaffective disorder. Twenty-three male outpatients previously stable but with inter-episode residual symptoms on classical antipsychotics and/or risperidone and who had complained of side effects were selected. Link: ./index.php?lvl=notice_display&id=31049

Influences of patient-related variables on risperidone efficacy for acutely exacerbated schizophrenia: analyses with rigorous statistics / Hsien Yuan Lane en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 353-358 Título : Influences of patient-related variables on risperidone efficacy for acutely exacerbated schizophrenia: analyses with rigorous statistics Tipo de documento: texto impreso Autores: Hsien Yuan Lane, Autor ; Yue Cune Chang, Autor ; Chi Chiang Chiu, Autor Fecha de publicación: 2023 Artículo en la página: pp. 353-358 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Hospitalización, Pacientes, Risperidona, Esquizofrenia Resumen: Response predictors of risperidone or other newer atypical antipsychotics for schizophrenia treatment remain unclear. This study aimed to investigate the influence of patient demographics on risperidone efficacy for schizophrenia. One hundred twenty-one newly hospitalized patients who had schizophrenia with acute exacerbation entered this prospective, 6-week risperidone trial. Link: ./index.php?lvl=notice_display&id=31050 [artículo] Influences of patient-related variables on risperidone efficacy for acutely exacerbated schizophrenia: analyses with rigorous statistics [texto impreso] / Hsien Yuan Lane, Autor ; Yue Cune Chang, Autor ; Chi Chiang Chiu, Autor . - 2023 . - pp. 353-358. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 353-358 Palabras clave: Antipsicóticos, Hospitalización, Pacientes, Risperidona, Esquizofrenia Resumen: Response predictors of risperidone or other newer atypical antipsychotics for schizophrenia treatment remain unclear. This study aimed to investigate the influence of patient demographics on risperidone efficacy for schizophrenia. One hundred twenty-one newly hospitalized patients who had schizophrenia with acute exacerbation entered this prospective, 6-week risperidone trial. Link: ./index.php?lvl=notice_display&id=31050

Effects of typical and atypical antipsychotics on the prepulse inhibition of the startle reflex in patients with schizophrenia / Bob Oranje en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 359-365 Título : Effects of typical and atypical antipsychotics on the prepulse inhibition of the startle reflex in patients with schizophrenia Tipo de documento: texto impreso Autores: Bob Oranje, Autor ; Clarine J. van Oel, Autor ; Christine C. Gispen De Wied, Autor Fecha de publicación: 2023 Artículo en la página: pp. 359-365 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Estimulación acústica, Agentes antipsicóticos, Reflejo, sobresalto, Esquizofrenia. Resumen: Patients with schizophrenia show a loss of sensory (motor) gating, which is reflected in a reduced prepulse inhibition (PPI) of the startle reflex. Furthermore, patients with schizophrenia habituate less than healthy subjects. From previous studies, it is clear that typical antipsychotics have little or no effect on either sensorimotor gating or habituation, while only limited data is available on the effects of atypical antipsychotics on these processes. Link: ./index.php?lvl=notice_display&id=31051 [artículo] Effects of typical and atypical antipsychotics on the prepulse inhibition of the startle reflex in patients with schizophrenia [texto impreso] / Bob Oranje, Autor ; Clarine J. van Oel, Autor ; Christine C. Gispen De Wied, Autor . - 2023 . - pp. 359-365. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 359-365 Palabras clave: Estimulación acústica, Agentes antipsicóticos, Reflejo, sobresalto, Esquizofrenia. Resumen: Patients with schizophrenia show a loss of sensory (motor) gating, which is reflected in a reduced prepulse inhibition (PPI) of the startle reflex. Furthermore, patients with schizophrenia habituate less than healthy subjects. From previous studies, it is clear that typical antipsychotics have little or no effect on either sensorimotor gating or habituation, while only limited data is available on the effects of atypical antipsychotics on these processes. Link: ./index.php?lvl=notice_display&id=31051

Influence of ritonavir on olanzapine pharmacokinetics in healthy volunteers / Scott R. Penzak en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 366-370 Título : Influence of ritonavir on olanzapine pharmacokinetics in healthy volunteers Tipo de documento: texto impreso Autores: Scott R. Penzak, Autor ; Yuen Yi Hon, Autor ; Walter D. Lawhorn, Autor Fecha de publicación: 2023 Artículo en la página: pp. 366-370 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Benzodiazepinas, Interacciones con medicamentos, Inhibidores de la proteasa del VIH, Pirenzepina, Ritonavir. Resumen: HIV infection and psychotic illnesses frequently coexist. The atypical antipsychotic olanzapine is metabolized primarily by CYP1A2 and glucuronosyl transferases, both of which are induced by the HIV protease inhibitor ritonavir. The purpose of this study was to determine the effect of ritonavir on the pharmacokinetics of a single dose of olanzapine. Link: ./index.php?lvl=notice_display&id=31052 [artículo] Influence of ritonavir on olanzapine pharmacokinetics in healthy volunteers [texto impreso] / Scott R. Penzak, Autor ; Yuen Yi Hon, Autor ; Walter D. Lawhorn, Autor . - 2023 . - pp. 366-370. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 366-370 Palabras clave: Antipsicóticos, Benzodiazepinas, Interacciones con medicamentos, Inhibidores de la proteasa del VIH, Pirenzepina, Ritonavir. Resumen: HIV infection and psychotic illnesses frequently coexist. The atypical antipsychotic olanzapine is metabolized primarily by CYP1A2 and glucuronosyl transferases, both of which are induced by the HIV protease inhibitor ritonavir. The purpose of this study was to determine the effect of ritonavir on the pharmacokinetics of a single dose of olanzapine. Link: ./index.php?lvl=notice_display&id=31052

The impact of cyp2c19 and cyp2d6 genotypes on metabolism of amitriptyline in japanese psychiatric patients / Kazutaka Shimoda en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 371-378 Título : The impact of cyp2c19 and cyp2d6 genotypes on metabolism of amitriptyline in japanese psychiatric patients Tipo de documento: texto impreso Autores: Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor ; Aya Yokono, Autor Fecha de publicación: 2023 Artículo en la página: pp. 371-378 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Amitriptilina, Agentes antidepresivos tricíclicos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Trastornos mentales, Oxigenasas de función mixta, Mutación. Resumen: We investigated the effect of the CYP2C19 and CYP2D6 genotypes on the metabolism of amitriptyline (AT) in Japanese psychiatric patients. Steady-state concentrations of AT and its metabolites (nortriptyline [NT], trans-10-hydroxy-nortriptyline [EHNT], cis-10-hydroxy-nortriptyline [ZHNT], trans-10-hydroxy-amitriptyline [EHAT], and cis-10-hydroxy-amitriptyline [ZHAT]) in 50 patients were determined by high-performance liquid chromatography. Link: ./index.php?lvl=notice_display&id=31053 [artículo] The impact of cyp2c19 and cyp2d6 genotypes on metabolism of amitriptyline in japanese psychiatric patients [texto impreso] / Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor ; Aya Yokono, Autor . - 2023 . - pp. 371-378. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 371-378 Palabras clave: Amitriptilina, Agentes antidepresivos tricíclicos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Trastornos mentales, Oxigenasas de función mixta, Mutación. Resumen: We investigated the effect of the CYP2C19 and CYP2D6 genotypes on the metabolism of amitriptyline (AT) in Japanese psychiatric patients. Steady-state concentrations of AT and its metabolites (nortriptyline [NT], trans-10-hydroxy-nortriptyline [EHNT], cis-10-hydroxy-nortriptyline [ZHNT], trans-10-hydroxy-amitriptyline [EHAT], and cis-10-hydroxy-amitriptyline [ZHAT]) in 50 patients were determined by high-performance liquid chromatography. Link: ./index.php?lvl=notice_display&id=31053

Double-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in partial responders and nonresponders to fluoxetine / Maurizio Fava en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 379-387 Título : Double-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in partial responders and nonresponders to fluoxetine Tipo de documento: texto impreso Autores: Maurizio Fava, Autor ; Jonathan E. Alpert, Autor ; Andrew A. Nierenberg, Autor Fecha de publicación: 2023 Artículo en la página: pp. 379-387 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos tricíclicos, Antimaníacos, Trastorno depresivo mayor, Desipramina, Terapia medicamentosa, Fluoxetina. Resumen: In a previous study, of 41 depressed patients who had not responded to fluoxetine 20 mg/day, 53% were treated with high-dose fluoxetine (40–60 mg/ day) and responded (i.e., their 17-item Hamilton Rating Scale for Depression [HAM-D-17] score was Link: ./index.php?lvl=notice_display&id=31054 [artículo] Double-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in partial responders and nonresponders to fluoxetine [texto impreso] / Maurizio Fava, Autor ; Jonathan E. Alpert, Autor ; Andrew A. Nierenberg, Autor . - 2023 . - pp. 379-387. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 379-387 Palabras clave: Antidepresivos tricíclicos, Antimaníacos, Trastorno depresivo mayor, Desipramina, Terapia medicamentosa, Fluoxetina. Resumen: In a previous study, of 41 depressed patients who had not responded to fluoxetine 20 mg/day, 53% were treated with high-dose fluoxetine (40–60 mg/ day) and responded (i.e., their 17-item Hamilton Rating Scale for Depression [HAM-D-17] score was Link: ./index.php?lvl=notice_display&id=31054

Effects of reboxetine on anxiety, agitation, and insomnia: results of a pooled evaluation of randomized clinical trials / Stephen M. Stahl en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 388-392 Título : Effects of reboxetine on anxiety, agitation, and insomnia: results of a pooled evaluation of randomized clinical trials Tipo de documento: texto impreso Autores: Stephen M. Stahl, Autor ; Joseph Mendels, Autor ; Gerri E. Schwartz, Autor Fecha de publicación: 2023 Artículo en la página: pp. 388-392 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Ansiedad, Trastorno depresivo mayor, Morfolinas, Agitación psicomotora, Ensayos controlados aleatorios, Trastornos de inicio y mantenimiento del sueño. Resumen: Several recent clinical trials have established that reboxetine, a new selective norepinephrine reuptake inhibitor (selective NRI), is effective and safe for the treatment of major depression. However, the effects of reboxetine on specific symptoms of anxiety, agitation, and insomnia have not been reported. Link: ./index.php?lvl=notice_display&id=31055 [artículo] Effects of reboxetine on anxiety, agitation, and insomnia: results of a pooled evaluation of randomized clinical trials [texto impreso] / Stephen M. Stahl, Autor ; Joseph Mendels, Autor ; Gerri E. Schwartz, Autor . - 2023 . - pp. 388-392. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 388-392 Palabras clave: Antidepresivos, Ansiedad, Trastorno depresivo mayor, Morfolinas, Agitación psicomotora, Ensayos controlados aleatorios, Trastornos de inicio y mantenimiento del sueño. Resumen: Several recent clinical trials have established that reboxetine, a new selective norepinephrine reuptake inhibitor (selective NRI), is effective and safe for the treatment of major depression. However, the effects of reboxetine on specific symptoms of anxiety, agitation, and insomnia have not been reported. Link: ./index.php?lvl=notice_display&id=31055

Reboxetine, a new noradrenaline selective antidepressant, is at least as effective as fluoxetine in the treatment of depression / Vittorino Andreoli en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 393-399 Título : Reboxetine, a new noradrenaline selective antidepressant, is at least as effective as fluoxetine in the treatment of depression Tipo de documento: texto impreso Autores: Vittorino Andreoli, Autor ; Vincent Caillard, Autor ; Ripu S. Deo, Autor Fecha de publicación: 2023 Artículo en la página: pp. 393-399 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Trastorno depresivo mayor, Fluoxetina, Morfolinas, Reboxetina, Inhibidores selectivos de la recaptación de serotonina. Resumen: The clinical profile of reboxetine, a selective noradrenaline reuptake inhibitor, was compared with that of the selective serotonin reuptake inhibitor fluoxetine and placebo in a double-blind, multicenter, parallel-group clinical trial of patients with major depression. Link: ./index.php?lvl=notice_display&id=31056 [artículo] Reboxetine, a new noradrenaline selective antidepressant, is at least as effective as fluoxetine in the treatment of depression [texto impreso] / Vittorino Andreoli, Autor ; Vincent Caillard, Autor ; Ripu S. Deo, Autor . - 2023 . - pp. 393-399. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 393-399 Palabras clave: Antidepresivos, Trastorno depresivo mayor, Fluoxetina, Morfolinas, Reboxetina, Inhibidores selectivos de la recaptación de serotonina. Resumen: The clinical profile of reboxetine, a selective noradrenaline reuptake inhibitor, was compared with that of the selective serotonin reuptake inhibitor fluoxetine and placebo in a double-blind, multicenter, parallel-group clinical trial of patients with major depression. Link: ./index.php?lvl=notice_display&id=31056

Effect of citalopram treatment on relationship between platelet serotonin functions and the karolinska scales of personality in panic patients / Jolanta Neuger en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 400-405 Título : Effect of citalopram treatment on relationship between platelet serotonin functions and the karolinska scales of personality in panic patients Tipo de documento: texto impreso Autores: Jolanta Neuger, Autor ; Börje Wistedt, Autor ; Anna Åberg Wistedt, Autor Fecha de publicación: 2023 Artículo en la página: pp. 400-405 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Plaquetas sanguíneas, Citalopram, Trastorno de pánico, Inhibidores selectivos de la recaptación de serotonina, Serotonina. Resumen: Using the Karolinska Scales of Personality (KSP), we investigated the effect of the selective serotonin reuptake inhibitor citalopram on personality traits and the relationship between personality traits and peripheral indexes for central serotonergic function in patients with panic disorder at baseline and after 6 months of treatment. Link: ./index.php?lvl=notice_display&id=31057 [artículo] Effect of citalopram treatment on relationship between platelet serotonin functions and the karolinska scales of personality in panic patients [texto impreso] / Jolanta Neuger, Autor ; Börje Wistedt, Autor ; Anna Åberg Wistedt, Autor . - 2023 . - pp. 400-405. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 400-405 Palabras clave: Plaquetas sanguíneas, Citalopram, Trastorno de pánico, Inhibidores selectivos de la recaptación de serotonina, Serotonina. Resumen: Using the Karolinska Scales of Personality (KSP), we investigated the effect of the selective serotonin reuptake inhibitor citalopram on personality traits and the relationship between personality traits and peripheral indexes for central serotonergic function in patients with panic disorder at baseline and after 6 months of treatment. Link: ./index.php?lvl=notice_display&id=31057

Serum levels of citalopram and its main metabolites in adolescent patients treated in a naturalistic clinical setting / Margareta Reis en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 406-413 Título : Serum levels of citalopram and its main metabolites in adolescent patients treated in a naturalistic clinical setting Tipo de documento: texto impreso Autores: Margareta Reis, Autor ; Gunilla Olsson, Autor ; Björn Carlsson, Autor Fecha de publicación: 2023 Artículo en la página: pp. 406-413 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Citalopram, Anticonceptivos orales, Trastorno depresivo mayor, Inhibidores selectivos de la recaptación de serotonina, Aspectos sexuales, Fumar. Resumen: The prescribing of selective serotonin reuptake inhibitors for adolescents is extensive despite the fact that there are few pharmacokinetic (PK), efficacy, safety, or tolerability studies on this group. This study reports the PK findings from two trials in adolescents treated with citalopram (CIT) in naturalistic clinical settings: one retrospective and one prospective. Link: ./index.php?lvl=notice_display&id=31058 [artículo] Serum levels of citalopram and its main metabolites in adolescent patients treated in a naturalistic clinical setting [texto impreso] / Margareta Reis, Autor ; Gunilla Olsson, Autor ; Björn Carlsson, Autor . - 2023 . - pp. 406-413. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 406-413 Palabras clave: Citalopram, Anticonceptivos orales, Trastorno depresivo mayor, Inhibidores selectivos de la recaptación de serotonina, Aspectos sexuales, Fumar. Resumen: The prescribing of selective serotonin reuptake inhibitors for adolescents is extensive despite the fact that there are few pharmacokinetic (PK), efficacy, safety, or tolerability studies on this group. This study reports the PK findings from two trials in adolescents treated with citalopram (CIT) in naturalistic clinical settings: one retrospective and one prospective. Link: ./index.php?lvl=notice_display&id=31058

A typological model for estimation of drug and placebo effects in depression / Donald C. Ross en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 414-418 Título : A typological model for estimation of drug and placebo effects in depression Tipo de documento: texto impreso Autores: Donald C. Ross, Autor ; Frederic Quitkin, Autor ; Donald F. Klein, Autor Fecha de publicación: 2023 Artículo en la página: pp. 414-418 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Ensayos clínicos, Trastorno depresivo mayor, Fluoxetina, Imipramina. Resumen: One reason for failure to find specific treatment effects in drug versus placebo trials with patients who have depression is an insufficient period of observation. Also, differentiating between early fleeting response and maintained response has been shown relevant to detecting specific drug action. A model in which various types of drug and placebo response are specifically stipulated and which takes advantage of a two-stage experimental design is proposed. Link: ./index.php?lvl=notice_display&id=31059 [artículo] A typological model for estimation of drug and placebo effects in depression [texto impreso] / Donald C. Ross, Autor ; Frederic Quitkin, Autor ; Donald F. Klein, Autor . - 2023 . - pp. 414-418. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 414-418 Palabras clave: Antidepresivos, Ensayos clínicos, Trastorno depresivo mayor, Fluoxetina, Imipramina. Resumen: One reason for failure to find specific treatment effects in drug versus placebo trials with patients who have depression is an insufficient period of observation. Also, differentiating between early fleeting response and maintained response has been shown relevant to detecting specific drug action. A model in which various types of drug and placebo response are specifically stipulated and which takes advantage of a two-stage experimental design is proposed. Link: ./index.php?lvl=notice_display&id=31059