Artículos

Olanzapine-exposed pregnancies and lactation: early experience / David J. Goldstein en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 399-403 Título : Olanzapine-exposed pregnancies and lactation: early experience Tipo de documento: texto impreso Autores: David J. Goldstein, Autor ; Lois A. Corbin, Autor ; Man C. Fung, Autor Fecha de publicación: 2023 Artículo en la página: pp. 399-403 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Aborto espontáneo, Antipsicóticos, Ensayos clínicos, Lactancia, Pirenzepina, Embarazo - complicaciones. Resumen: Psychosis frequently occurs in women of child-bearing potential who may have unplanned pregnancies. Understanding the risk of prenatal antipsychotic exposure can be of benefit in selecting therapies. The authors evaluated the in utero and lactation exposure effects of olanzapine, a novel antipsychotic that is used in treating schizophrenia, bipolar disorder, and other conditions and that may have expanded use in the childbearing population. Link: ./index.php?lvl=notice_display&id=31174 [artículo] Olanzapine-exposed pregnancies and lactation: early experience [texto impreso] / David J. Goldstein, Autor ; Lois A. Corbin, Autor ; Man C. Fung, Autor . - 2023 . - pp. 399-403. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 399-403 Palabras clave: Aborto espontáneo, Antipsicóticos, Ensayos clínicos, Lactancia, Pirenzepina, Embarazo - complicaciones. Resumen: Psychosis frequently occurs in women of child-bearing potential who may have unplanned pregnancies. Understanding the risk of prenatal antipsychotic exposure can be of benefit in selecting therapies. The authors evaluated the in utero and lactation exposure effects of olanzapine, a novel antipsychotic that is used in treating schizophrenia, bipolar disorder, and other conditions and that may have expanded use in the childbearing population. Link: ./index.php?lvl=notice_display&id=31174

Therapeutic spectrum of nemonapride and its relationship with plasma concentrations of the drug and prolactin / Tsuyoshi Kondo en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 404-409 Título : Therapeutic spectrum of nemonapride and its relationship with plasma concentrations of the drug and prolactin Tipo de documento: texto impreso Autores: Tsuyoshi Kondo, Autor ; Kazuo Mihara, Autor ; Norio Yasui Furukori, Autor Fecha de publicación: 2023 Artículo en la página: pp. 404-409 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Benzamidas, Biotransformación, Prolactina, Esquizofrenia. Resumen: The therapeutic spectrum of nemonapride, a new substituted benzamide, and its relationship with plasma concentrations of the drug and prolactin were investigated by a fixed-dose study (18 mg/day for 3 weeks) in 31 patients with acutely exacerbated schizophrenia. Of 31 patients, 25 (80.6%) were responders who showed a reduction in symptoms (percentage of improvement) of 50% or more after 3 weeks. Link: ./index.php?lvl=notice_display&id=31175 [artículo] Therapeutic spectrum of nemonapride and its relationship with plasma concentrations of the drug and prolactin [texto impreso] / Tsuyoshi Kondo, Autor ; Kazuo Mihara, Autor ; Norio Yasui Furukori, Autor . - 2023 . - pp. 404-409. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 404-409 Palabras clave: Antipsicóticos, Benzamidas, Biotransformación, Prolactina, Esquizofrenia. Resumen: The therapeutic spectrum of nemonapride, a new substituted benzamide, and its relationship with plasma concentrations of the drug and prolactin were investigated by a fixed-dose study (18 mg/day for 3 weeks) in 31 patients with acutely exacerbated schizophrenia. Of 31 patients, 25 (80.6%) were responders who showed a reduction in symptoms (percentage of improvement) of 50% or more after 3 weeks. Link: ./index.php?lvl=notice_display&id=31175

Obsessive and compulsive symptoms in schizophrenia: a randomized controlled trial with fluvoxamine and neuroleptics / Ilya Reznik en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 410-416 Título : Obsessive and compulsive symptoms in schizophrenia: a randomized controlled trial with fluvoxamine and neuroleptics Tipo de documento: texto impreso Autores: Ilya Reznik, Autor ; Pinkhas Sirota, Autor Fecha de publicación: 2023 Artículo en la página: pp. 410-416 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Comportamiento compulsivo, Fluvoxamina, Haloperidol, Comportamiento obsesivo, Esquizofrenia. Resumen: Obsessive-compulsive-related disorders are frequently comorbid with schizophrenia. The existence of obsessive and compulsive symptoms in patients with schizophrenia represents one of the most severe types of psychotic disorders and may predict a poor prognosis in most cases. Previous pilot studies and case reports have shown that the condition of some patients with schizophrenia did not exacerbate and even improved when serotonin reuptake inhibitors (SSRIs) were added to their standard neuroleptic regimen. Link: ./index.php?lvl=notice_display&id=31176 [artículo] Obsessive and compulsive symptoms in schizophrenia: a randomized controlled trial with fluvoxamine and neuroleptics [texto impreso] / Ilya Reznik, Autor ; Pinkhas Sirota, Autor . - 2023 . - pp. 410-416. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 410-416 Palabras clave: Antipsicóticos, Comportamiento compulsivo, Fluvoxamina, Haloperidol, Comportamiento obsesivo, Esquizofrenia. Resumen: Obsessive-compulsive-related disorders are frequently comorbid with schizophrenia. The existence of obsessive and compulsive symptoms in patients with schizophrenia represents one of the most severe types of psychotic disorders and may predict a poor prognosis in most cases. Previous pilot studies and case reports have shown that the condition of some patients with schizophrenia did not exacerbate and even improved when serotonin reuptake inhibitors (SSRIs) were added to their standard neuroleptic regimen. Link: ./index.php?lvl=notice_display&id=31176

Intravenous versus oral administration of amitriptyline in patients with major depression / Eberhard A. Deisenhammer en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 417-422 Título : Intravenous versus oral administration of amitriptyline in patients with major depression Tipo de documento: texto impreso Autores: Eberhard A. Deisenhammer, Autor ; Alexandra B. Whitworth, Autor ; Christian Geretsegger, Autor Fecha de publicación: 2023 Artículo en la página: pp. 417-422 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Amitriptilina, Antidepresivos tricíclicos, Trastorno depresivo, Interacciones con la drogas. Resumen: Antidepressants can be administered by different routes. Advantages for either the oral or the intravenous administration have been suggested from pharmacokinetic as well as from clinical points of view. Controlled comparison studies of the two routes do not provide unequivocal recommendations. In this investigation, amitriptyline was studied over a 4-week period consisting of a 2-week, double-blind/double-dummy phase with either oral (150 mg/day), high-dose intravenous (150 mg/day), or medium-dose intravenous (100 mg/day) treatment and a 2-week phase of open oral treatment in 80 patients with major depression. Link: ./index.php?lvl=notice_display&id=31177 [artículo] Intravenous versus oral administration of amitriptyline in patients with major depression [texto impreso] / Eberhard A. Deisenhammer, Autor ; Alexandra B. Whitworth, Autor ; Christian Geretsegger, Autor . - 2023 . - pp. 417-422. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 417-422 Palabras clave: Amitriptilina, Antidepresivos tricíclicos, Trastorno depresivo, Interacciones con la drogas. Resumen: Antidepressants can be administered by different routes. Advantages for either the oral or the intravenous administration have been suggested from pharmacokinetic as well as from clinical points of view. Controlled comparison studies of the two routes do not provide unequivocal recommendations. In this investigation, amitriptyline was studied over a 4-week period consisting of a 2-week, double-blind/double-dummy phase with either oral (150 mg/day), high-dose intravenous (150 mg/day), or medium-dose intravenous (100 mg/day) treatment and a 2-week phase of open oral treatment in 80 patients with major depression. Link: ./index.php?lvl=notice_display&id=31177

Weekly dosing of fluoxetine for the continuation phase of treatment of major depression: results of a placebo-controlled, randomized clinical trial / William J. Burke en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 423-427 Título : Weekly dosing of fluoxetine for the continuation phase of treatment of major depression: results of a placebo-controlled, randomized clinical trial Tipo de documento: texto impreso Autores: William J. Burke, Autor ; Shelton E. Hendricks, Autor ; Delores McArthur Miller, Autor Fecha de publicación: 2023 Artículo en la página: pp. 423-427 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos de segunda generación, Trastorno depresivo, Fluoxetina. Resumen: Fluoxetine (FLX) has a unique pharmacokinetic profile. Its major metabolite, norfluoxetine (NFLX), possesses FLX's antidepressant efficacy and a half-life of 7 to 15 days, suggesting the possibility of nonstandard dosing strategies. This study examined the tolerability of a weekly dose and its equivalence to daily dosing of FLX for the continuation phase of treatment for major depressive disorder (MDD). Link: ./index.php?lvl=notice_display&id=31178 [artículo] Weekly dosing of fluoxetine for the continuation phase of treatment of major depression: results of a placebo-controlled, randomized clinical trial [texto impreso] / William J. Burke, Autor ; Shelton E. Hendricks, Autor ; Delores McArthur Miller, Autor . - 2023 . - pp. 423-427. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 423-427 Palabras clave: Antidepresivos de segunda generación, Trastorno depresivo, Fluoxetina. Resumen: Fluoxetine (FLX) has a unique pharmacokinetic profile. Its major metabolite, norfluoxetine (NFLX), possesses FLX's antidepressant efficacy and a half-life of 7 to 15 days, suggesting the possibility of nonstandard dosing strategies. This study examined the tolerability of a weekly dose and its equivalence to daily dosing of FLX for the continuation phase of treatment for major depressive disorder (MDD). Link: ./index.php?lvl=notice_display&id=31178

Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes / Alex Hemeryck en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 428-434 Título : Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes Tipo de documento: texto impreso Autores: Alex Hemeryck, Autor ; Cindy De Vriendt, Autor ; Frans M. Belpaire, Autor Fecha de publicación: 2023 Artículo en la página: pp. 428-434 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antiarritmias, Desalquilación, Depresión, Hidroxilación, Técnicas In Vitro, Microsomas, Propafenona. Resumen: Propafenone is mainly metabolized by CYP2D6 to form 5-hydroxypropafenone (5-OHP) and to a minor extent by CYP1A2 and CYP3A4 to form N-depropylpropafenone (N-DPP). The in vitro inhibitory effect of selective serotonin reuptake inhibitors (SSRIs) on the formation of both metabolites was studied, using human liver microsomes. Link: ./index.php?lvl=notice_display&id=31179 [artículo] Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes [texto impreso] / Alex Hemeryck, Autor ; Cindy De Vriendt, Autor ; Frans M. Belpaire, Autor . - 2023 . - pp. 428-434. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 428-434 Palabras clave: Antiarritmias, Desalquilación, Depresión, Hidroxilación, Técnicas In Vitro, Microsomas, Propafenona. Resumen: Propafenone is mainly metabolized by CYP2D6 to form 5-hydroxypropafenone (5-OHP) and to a minor extent by CYP1A2 and CYP3A4 to form N-depropylpropafenone (N-DPP). The in vitro inhibitory effect of selective serotonin reuptake inhibitors (SSRIs) on the formation of both metabolites was studied, using human liver microsomes. Link: ./index.php?lvl=notice_display&id=31179

Inhibition of cytochrome p450 2d6 modifies codeine abuse liability / Kalyani Kathiramalainathan en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 435-444 Título : Inhibition of cytochrome p450 2d6 modifies codeine abuse liability Tipo de documento: texto impreso Autores: Kalyani Kathiramalainathan, Autor ; Howard L. Kaplan, Autor ; Myroslava K. Romach, Autor Fecha de publicación: 2023 Artículo en la página: pp. 435-444 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Codeína, Inhibidores del citocromo P-450 CYP2D6, Inhibidores enzimáticos, Narcóticos, Trastornos relacionados con los opioides, Efectos de la pupila, Quinidina. Resumen: Oral codeine preparations, widely used for analgesia and cough suppression, are abused by some individuals for their mood-altering properties. The enzymatic O-demethylation of codeine is catalyzed by cytochrome P450 2D6 (CYP2D6), leading to the production of metabolites (morphine, morphine-6-glucuronide) that are pharmacologically more potent than codeine. A placebo-controlled, single-blind study was conducted to characterize the subjective effects of codeine associated with abuse liability and to determine the importance of metabolic O-demethylation to codeine abuse liability. Link: ./index.php?lvl=notice_display&id=31180 [artículo] Inhibition of cytochrome p450 2d6 modifies codeine abuse liability [texto impreso] / Kalyani Kathiramalainathan, Autor ; Howard L. Kaplan, Autor ; Myroslava K. Romach, Autor . - 2023 . - pp. 435-444. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 435-444 Palabras clave: Codeína, Inhibidores del citocromo P-450 CYP2D6, Inhibidores enzimáticos, Narcóticos, Trastornos relacionados con los opioides, Efectos de la pupila, Quinidina. Resumen: Oral codeine preparations, widely used for analgesia and cough suppression, are abused by some individuals for their mood-altering properties. The enzymatic O-demethylation of codeine is catalyzed by cytochrome P450 2D6 (CYP2D6), leading to the production of metabolites (morphine, morphine-6-glucuronide) that are pharmacologically more potent than codeine. A placebo-controlled, single-blind study was conducted to characterize the subjective effects of codeine associated with abuse liability and to determine the importance of metabolic O-demethylation to codeine abuse liability. Link: ./index.php?lvl=notice_display&id=31180

Event-related brain potentials and working memory function in healthy humans after single-dose and prolonged intranasal administration of adrenocorticotropin 4-10 and desacetyl-α-melanocyte stimulating hormone / Rüdiger Smolnik en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 445-454 Título : Event-related brain potentials and working memory function in healthy humans after single-dose and prolonged intranasal administration of adrenocorticotropin 4-10 and desacetyl-α-melanocyte stimulating hormone Tipo de documento: texto impreso Autores: Rüdiger Smolnik, Autor ; Boris Perras, Autor ; Matthias Möller, Autor Fecha de publicación: 2023 Artículo en la página: pp. 445-454 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Hormona adrenocorticotrópica, Afecto, Excitación, Electroencefalografía, Memoria a corto plazo, Nootrópicos, Fragmentos de péptidos, Rendimiento psicomotor, alfa-MSH. Resumen: Neuropeptides of the adrenocorticotropin/melanocorticotropin (ACTH/MSH) family are most potent modulators of cognitive function. Their neurobehavioral activity is principally encoded in the 4-10 fragment of the ACTH/MSH molecule; in humans, it has been shown to pertain primarily to functions of attentive stimulus/response processing. Link: ./index.php?lvl=notice_display&id=31181 [artículo] Event-related brain potentials and working memory function in healthy humans after single-dose and prolonged intranasal administration of adrenocorticotropin 4-10 and desacetyl-α-melanocyte stimulating hormone [texto impreso] / Rüdiger Smolnik, Autor ; Boris Perras, Autor ; Matthias Möller, Autor . - 2023 . - pp. 445-454. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 445-454 Palabras clave: Hormona adrenocorticotrópica, Afecto, Excitación, Electroencefalografía, Memoria a corto plazo, Nootrópicos, Fragmentos de péptidos, Rendimiento psicomotor, alfa-MSH. Resumen: Neuropeptides of the adrenocorticotropin/melanocorticotropin (ACTH/MSH) family are most potent modulators of cognitive function. Their neurobehavioral activity is principally encoded in the 4-10 fragment of the ACTH/MSH molecule; in humans, it has been shown to pertain primarily to functions of attentive stimulus/response processing. Link: ./index.php?lvl=notice_display&id=31181

Human pharmacology of 3,4-methylenedioxymeth-amphetamine ("ecstasy"): psychomotor performance and subjective effects / Jordi Camí en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 455-466 Título : Human pharmacology of 3,4-methylenedioxymeth-amphetamine ("ecstasy"): psychomotor performance and subjective effects Tipo de documento: texto impreso Autores: Jordi Camí, Autor ; Magi Farré, Autor ; Marta Mas, Autor Fecha de publicación: 2023 Artículo en la página: pp. 455-466 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Afecto, Confusión, Alucinógenos, Metil-3,4-metilendioxianfetamina, Rendimiento psicomotor. Resumen: 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a recreational drug of increasing use among youth because of its apparent entactogenic properties, such as euphoria, friendliness, closeness, and empathy. However, experimental studies have shown MDMA to be neurotoxic. Data on pharmacologic actions of MDMA in humans are limited. The authors conducted a randomized, double-blind, crossover, controlled trial to assess psychomotor performance and subjective effects in eight healthy male volunteers. Link: ./index.php?lvl=notice_display&id=31182 [artículo] Human pharmacology of 3,4-methylenedioxymeth-amphetamine ("ecstasy"): psychomotor performance and subjective effects [texto impreso] / Jordi Camí, Autor ; Magi Farré, Autor ; Marta Mas, Autor . - 2023 . - pp. 455-466. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 455-466 Palabras clave: Afecto, Confusión, Alucinógenos, Metil-3,4-metilendioxianfetamina, Rendimiento psicomotor. Resumen: 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a recreational drug of increasing use among youth because of its apparent entactogenic properties, such as euphoria, friendliness, closeness, and empathy. However, experimental studies have shown MDMA to be neurotoxic. Data on pharmacologic actions of MDMA in humans are limited. The authors conducted a randomized, double-blind, crossover, controlled trial to assess psychomotor performance and subjective effects in eight healthy male volunteers. Link: ./index.php?lvl=notice_display&id=31182

Placebo-controlled study of gabapentin treatment of panic disorder / Atul C. Pande en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 467-471 Título : Placebo-controlled study of gabapentin treatment of panic disorder Tipo de documento: texto impreso Autores: Atul C. Pande, Autor ; Mark H. Pollack, Autor ; Jerri G. Crockatt, Autor Fecha de publicación: 2023 Artículo en la página: pp. 467-471 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Agorafobia, Aminas, Ansiolíticos, Ácidos ciclohexanocarboxílicos, Gabapentina, Trastorno de pánico, Características sexuales. Resumen: A randomized, double-blind, placebo-controlled, parallel-group study was conducted to evaluate the efficacy and safety of gabapentin in relieving the symptoms of panic disorder. One hundred three patients were randomly assigned to receive double-blind treatment with either gabapentin (dosed flexibly between 600 and 3,600 mg/day) or placebo for 8 weeks. Link: ./index.php?lvl=notice_display&id=31183 [artículo] Placebo-controlled study of gabapentin treatment of panic disorder [texto impreso] / Atul C. Pande, Autor ; Mark H. Pollack, Autor ; Jerri G. Crockatt, Autor . - 2023 . - pp. 467-471. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 467-471 Palabras clave: Agorafobia, Aminas, Ansiolíticos, Ácidos ciclohexanocarboxílicos, Gabapentina, Trastorno de pánico, Características sexuales. Resumen: A randomized, double-blind, placebo-controlled, parallel-group study was conducted to evaluate the efficacy and safety of gabapentin in relieving the symptoms of panic disorder. One hundred three patients were randomly assigned to receive double-blind treatment with either gabapentin (dosed flexibly between 600 and 3,600 mg/day) or placebo for 8 weeks. Link: ./index.php?lvl=notice_display&id=31183

Specific sensory detection, discrimination, and hedonic estimation of nicotine enantiomers in smokers and nonsmokers: are there limitations in replacing the sensory components of nicotine? / Norbert Thuerauf en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 472-478 Título : Specific sensory detection, discrimination, and hedonic estimation of nicotine enantiomers in smokers and nonsmokers: are there limitations in replacing the sensory components of nicotine? Tipo de documento: texto impreso Autores: Norbert Thuerauf, Autor ; Michael Kaegler, Autor ; Bertold Renner, Autor Fecha de publicación: 2023 Artículo en la página: pp. 472-478 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Discriminación, Nicotina, Agonistas nicotínicos, Sensación, Umbrales sensoriales, Tabaquismo. Resumen: The aim of this study was to investigate in smokers and nonsmokers (1) the olfactory and trigeminal detection of R(+)- and S(−)-nicotine and (2) the discrimination ability and hedonic estimation of nicotine enantiomers in olfactory and trigeminal concentrations. Thirty healthy male subjects (15 smokers, 15 nonsmokers) participated in the experiments. A randomized sequence of R(+)- and S(−)-nicotine stimuli (seven R(+)- and seven S(−)-nicotine stimuli) were introduced into the right nostril of the subjects using a Kobal-olfactometer. Link: ./index.php?lvl=notice_display&id=31184 [artículo] Specific sensory detection, discrimination, and hedonic estimation of nicotine enantiomers in smokers and nonsmokers: are there limitations in replacing the sensory components of nicotine? [texto impreso] / Norbert Thuerauf, Autor ; Michael Kaegler, Autor ; Bertold Renner, Autor . - 2023 . - pp. 472-478. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 472-478 Palabras clave: Discriminación, Nicotina, Agonistas nicotínicos, Sensación, Umbrales sensoriales, Tabaquismo. Resumen: The aim of this study was to investigate in smokers and nonsmokers (1) the olfactory and trigeminal detection of R(+)- and S(−)-nicotine and (2) the discrimination ability and hedonic estimation of nicotine enantiomers in olfactory and trigeminal concentrations. Thirty healthy male subjects (15 smokers, 15 nonsmokers) participated in the experiments. A randomized sequence of R(+)- and S(−)-nicotine stimuli (seven R(+)- and seven S(−)-nicotine stimuli) were introduced into the right nostril of the subjects using a Kobal-olfactometer. Link: ./index.php?lvl=notice_display&id=31184