Artículos

Evaluation of sexual functioning in depressed outpatients: a double-blind comparison of sustained-release bupropion and sertraline treatment / R. Taylor Segraves en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 122-128 Título : Evaluation of sexual functioning in depressed outpatients: a double-blind comparison of sustained-release bupropion and sertraline treatment Tipo de documento: texto impreso Autores: R. Taylor Segraves, Autor ; Richard Kavoussi, Autor ; Arlene R. Hughes, Autor Fecha de publicación: 2023 Artículo en la página: pp. 122-128 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos de segunda generación, Bupropión, Trastorno depresivo, Sertralina, Comportamiento sexual. Resumen: Sexual dysfunction is a frequently reported side effect of many antidepressants, including serotonin reuptake inhibitors. Bupropion, an antidepressant of the aminoketone class, is relatively free of adverse sexual effects. In a randomized, double-blind, multicenter trial, sustained-release bupropion (bupropion SR) and sertraline, a selective serotonin reuptake inhibitor, were found to be similarly efficacious in the treatment of outpatients with moderate to severe depression. Link: ./index.php?lvl=notice_display&id=31205 [artículo] Evaluation of sexual functioning in depressed outpatients: a double-blind comparison of sustained-release bupropion and sertraline treatment [texto impreso] / R. Taylor Segraves, Autor ; Richard Kavoussi, Autor ; Arlene R. Hughes, Autor . - 2023 . - pp. 122-128. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 122-128 Palabras clave: Antidepresivos de segunda generación, Bupropión, Trastorno depresivo, Sertralina, Comportamiento sexual. Resumen: Sexual dysfunction is a frequently reported side effect of many antidepressants, including serotonin reuptake inhibitors. Bupropion, an antidepressant of the aminoketone class, is relatively free of adverse sexual effects. In a randomized, double-blind, multicenter trial, sustained-release bupropion (bupropion SR) and sertraline, a selective serotonin reuptake inhibitor, were found to be similarly efficacious in the treatment of outpatients with moderate to severe depression. Link: ./index.php?lvl=notice_display&id=31205

Nefazodone treatment of major depression in alcohol-dependent patients: a double-blind, placebo-controlled trial / Peter P. Roy Byrne en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 129-136 Título : Nefazodone treatment of major depression in alcohol-dependent patients: a double-blind, placebo-controlled trial Tipo de documento: texto impreso Autores: Peter P. Roy Byrne, Autor ; Kenneth P. Pages, Autor ; Joan E. Russo, Autor Fecha de publicación: 2023 Artículo en la página: pp. 129-136 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Alcoholismo, Antidepresivos de segunda generación, Terapia de modalidad combinada, Trastorno depresivo mayor, Psicoterapia de grupo, Triazoles. Resumen: Depression is the most common comorbid psychiatric illness in patients with alcohol dependence. This double-blind study tested the efficacy of nefazodone versus placebo for the treatment of depression in actively drinking alcohol-dependent patients who were also participating in weekly group treatment for alcoholism. Link: ./index.php?lvl=notice_display&id=31206 [artículo] Nefazodone treatment of major depression in alcohol-dependent patients: a double-blind, placebo-controlled trial [texto impreso] / Peter P. Roy Byrne, Autor ; Kenneth P. Pages, Autor ; Joan E. Russo, Autor . - 2023 . - pp. 129-136. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 129-136 Palabras clave: Alcoholismo, Antidepresivos de segunda generación, Terapia de modalidad combinada, Trastorno depresivo mayor, Psicoterapia de grupo, Triazoles. Resumen: Depression is the most common comorbid psychiatric illness in patients with alcohol dependence. This double-blind study tested the efficacy of nefazodone versus placebo for the treatment of depression in actively drinking alcohol-dependent patients who were also participating in weekly group treatment for alcoholism. Link: ./index.php?lvl=notice_display&id=31206

Evaluation of platelet activation in depressed patients with ischemic heart disease after paroxetine or nortriptyline treatment / Bruce G. Pollock en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 137-140 Título : Evaluation of platelet activation in depressed patients with ischemic heart disease after paroxetine or nortriptyline treatment Tipo de documento: texto impreso Autores: Bruce G. Pollock, Autor ; Fouzia Laghrissi Thode, Autor Fecha de publicación: 2023 Artículo en la página: pp. 137-140 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos tricíclicos, Enfermedad Coronaria, Trastorno depresivo, Nortriptilina, Paroxetina. Resumen: This study investigated the effects of antidepressant treatment on platelet activation in depressed patients with ischemic heart disease (IHD). Plasma levels of platelet α-granule release products β-thromboglobulin (BTG) and platelet factor 4 (PF4) were measured in 17 depressed patients with IHD who were treated in a 6-week, double-blind trial with either paroxetine (10 patients) or nortriptyline (7 patients). Link: ./index.php?lvl=notice_display&id=31207 [artículo] Evaluation of platelet activation in depressed patients with ischemic heart disease after paroxetine or nortriptyline treatment [texto impreso] / Bruce G. Pollock, Autor ; Fouzia Laghrissi Thode, Autor . - 2023 . - pp. 137-140. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 137-140 Palabras clave: Antidepresivos tricíclicos, Enfermedad Coronaria, Trastorno depresivo, Nortriptilina, Paroxetina. Resumen: This study investigated the effects of antidepressant treatment on platelet activation in depressed patients with ischemic heart disease (IHD). Plasma levels of platelet α-granule release products β-thromboglobulin (BTG) and platelet factor 4 (PF4) were measured in 17 depressed patients with IHD who were treated in a 6-week, double-blind trial with either paroxetine (10 patients) or nortriptyline (7 patients). Link: ./index.php?lvl=notice_display&id=31207

Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline / Sachiyo Morita en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 141-149 Título : Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline Tipo de documento: texto impreso Autores: Sachiyo Morita, Autor ; Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor Fecha de publicación: 2023 Artículo en la página: pp. 141-149 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos de adaptación, Trastorno bipolar, Trastorno depresivo mayor, Etnia - genética, Nortriptilina. Resumen: The authors investigated the impact of the CYP2D6 genotype on steady-state concentrations of nortriptyline (NT) and its metabolites, trans-10-hydroxynortriptyline (EHNT) and cis-10-hydroxynortriptyline in a Japanese population of psychiatric patients. Forty-one patients (20 men and 21 women) were orally administered nortriptyline hydrochloride. Link: ./index.php?lvl=notice_display&id=31208 [artículo] Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline [texto impreso] / Sachiyo Morita, Autor ; Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor . - 2023 . - pp. 141-149. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 141-149 Palabras clave: Trastornos de adaptación, Trastorno bipolar, Trastorno depresivo mayor, Etnia - genética, Nortriptilina. Resumen: The authors investigated the impact of the CYP2D6 genotype on steady-state concentrations of nortriptyline (NT) and its metabolites, trans-10-hydroxynortriptyline (EHNT) and cis-10-hydroxynortriptyline in a Japanese population of psychiatric patients. Forty-one patients (20 men and 21 women) were orally administered nortriptyline hydrochloride. Link: ./index.php?lvl=notice_display&id=31208

Dose-response evaluation of the interaction between sertraline and alprazolam in vivo / Paul C. Hassan en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 150-158 Título : Dose-response evaluation of the interaction between sertraline and alprazolam in vivo Tipo de documento: texto impreso Autores: Paul C. Hassan, Autor ; Beth A. Sproule, Autor ; Claudio A. Naranjo, Autor Fecha de publicación: 2023 Artículo en la página: pp. 150-158 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Alprazolam, Agentes ansiolíticos, Antidepresivos de segunda generación, Recuerdo mental, Pruebas neuropsicológicas, Rendimiento psicomotor. Resumen: In vitro data show the inhibition of alprazolam metabolism by sertraline via CYP3A4; therefore, using a randomized, double-blind, placebo-controlled design, the authors conducted this study to assess the potential for similar in vivo inhibition in humans. Ten healthy volunteers participated in two test sessions (placebo/alprazolam 1 mg orally) before the initiation of sertraline treatment. Link: ./index.php?lvl=notice_display&id=31209 [artículo] Dose-response evaluation of the interaction between sertraline and alprazolam in vivo [texto impreso] / Paul C. Hassan, Autor ; Beth A. Sproule, Autor ; Claudio A. Naranjo, Autor . - 2023 . - pp. 150-158. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 150-158 Palabras clave: Alprazolam, Agentes ansiolíticos, Antidepresivos de segunda generación, Recuerdo mental, Pruebas neuropsicológicas, Rendimiento psicomotor. Resumen: In vitro data show the inhibition of alprazolam metabolism by sertraline via CYP3A4; therefore, using a randomized, double-blind, placebo-controlled design, the authors conducted this study to assess the potential for similar in vivo inhibition in humans. Ten healthy volunteers participated in two test sessions (placebo/alprazolam 1 mg orally) before the initiation of sertraline treatment. Link: ./index.php?lvl=notice_display&id=31209

Nefazodone treatment for chronic posttraumatic stress disorder: an open trial / Lori L. Davis en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 159-164 Título : Nefazodone treatment for chronic posttraumatic stress disorder: an open trial Tipo de documento: texto impreso Autores: Lori L. Davis, Autor ; Alexandria L. Nugent, Autor ; Jenny Murray, Autor Fecha de publicación: 2023 Artículo en la página: pp. 159-164 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos de segunda generación, Enfermedad crónica, Trastornos de combate, Trastornos de estrés postraumático, Triazoles. Resumen: Currently, there is no standard treatment for posttraumatic stress disorder (PTSD) because of a deficit of systematic treatment trials. The symptom overlap with other mood and anxiety disorders that respond to antidepressants and the results of a limited number of antidepressant trials indicate promise for psychopharmacologic treatment. Link: ./index.php?lvl=notice_display&id=31210 [artículo] Nefazodone treatment for chronic posttraumatic stress disorder: an open trial [texto impreso] / Lori L. Davis, Autor ; Alexandria L. Nugent, Autor ; Jenny Murray, Autor . - 2023 . - pp. 159-164. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 159-164 Palabras clave: Antidepresivos de segunda generación, Enfermedad crónica, Trastornos de combate, Trastornos de estrés postraumático, Triazoles. Resumen: Currently, there is no standard treatment for posttraumatic stress disorder (PTSD) because of a deficit of systematic treatment trials. The symptom overlap with other mood and anxiety disorders that respond to antidepressants and the results of a limited number of antidepressant trials indicate promise for psychopharmacologic treatment. Link: ./index.php?lvl=notice_display&id=31210

Increased sensitivity to stress in spontaneous recurrence of methamphetamine psychosis: noradrenergic hyperactivity with contribution from dopaminergic hyperactivity / Kunio Yui en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 165-174 Título : Increased sensitivity to stress in spontaneous recurrence of methamphetamine psychosis: noradrenergic hyperactivity with contribution from dopaminergic hyperactivity Tipo de documento: texto impreso Autores: Kunio Yui, Autor ; Kimihiko Goto, Autor ; Shigenori Ikemoto, Autor Fecha de publicación: 2023 Artículo en la página: pp. 165-174 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Excitación, Efectos cerebrales, Cerebro - fisiopatología, Estimulantes del Sistema Nervioso Central, Recuerdo mental, Noradrenalina, Psicosis inducidas por sustancias, Estrés psicológico. Resumen: The significance of increased sensitivity to stress associated with nora drenergic hyperactivity involving dopaminergic change in spontaneous recurrences of methamphetamine (MAP) psychosis (flashbacks) was examined. Plasma monoamine metabolite levels were assayed in 18 subjects with flashbacks who had been exposed to stressful events plus MAP-induced frightening psychotic symptoms (N = 11) or frightening psychotic symptoms alone (N = 7) during previous MAP use, in 15 nonflashbackers with a history of MAP psychosis, in 8 subjects with persistent MAP psychosis, and in 27 control subjects. Link: ./index.php?lvl=notice_display&id=31211 [artículo] Increased sensitivity to stress in spontaneous recurrence of methamphetamine psychosis: noradrenergic hyperactivity with contribution from dopaminergic hyperactivity [texto impreso] / Kunio Yui, Autor ; Kimihiko Goto, Autor ; Shigenori Ikemoto, Autor . - 2023 . - pp. 165-174. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 165-174 Palabras clave: Excitación, Efectos cerebrales, Cerebro - fisiopatología, Estimulantes del Sistema Nervioso Central, Recuerdo mental, Noradrenalina, Psicosis inducidas por sustancias, Estrés psicológico. Resumen: The significance of increased sensitivity to stress associated with nora drenergic hyperactivity involving dopaminergic change in spontaneous recurrences of methamphetamine (MAP) psychosis (flashbacks) was examined. Plasma monoamine metabolite levels were assayed in 18 subjects with flashbacks who had been exposed to stressful events plus MAP-induced frightening psychotic symptoms (N = 11) or frightening psychotic symptoms alone (N = 7) during previous MAP use, in 15 nonflashbackers with a history of MAP psychosis, in 8 subjects with persistent MAP psychosis, and in 27 control subjects. Link: ./index.php?lvl=notice_display&id=31211

Interindividual variation in bromperidol metabolism and relationship to therapeutic effects / Toshiyuki Someya en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 175-180 Título : Interindividual variation in bromperidol metabolism and relationship to therapeutic effects Tipo de documento: texto impreso Autores: Toshiyuki Someya, Autor ; Tatsuyuki Muratake, Autor ; Genta Hirokane, Autor Fecha de publicación: 2023 Artículo en la página: pp. 175-180 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Biotransformación, Haloperidol, Esquizofrenia. Resumen: Plasma concentrations of bromperidol (BRP) and reduced bromperidol (RBRP) were determined in 31 patients with schizophrenia who were administered BRP for their psychiatric symptoms. Activities of carbonyl reductase in red blood cells were assayed using BRP as a substrate. Link: ./index.php?lvl=notice_display&id=31212 [artículo] Interindividual variation in bromperidol metabolism and relationship to therapeutic effects [texto impreso] / Toshiyuki Someya, Autor ; Tatsuyuki Muratake, Autor ; Genta Hirokane, Autor . - 2023 . - pp. 175-180. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 175-180 Palabras clave: Antipsicóticos, Biotransformación, Haloperidol, Esquizofrenia. Resumen: Plasma concentrations of bromperidol (BRP) and reduced bromperidol (RBRP) were determined in 31 patients with schizophrenia who were administered BRP for their psychiatric symptoms. Activities of carbonyl reductase in red blood cells were assayed using BRP as a substrate. Link: ./index.php?lvl=notice_display&id=31212

Pharmacologic profile of perphenazine's metabolites / Robert A. Sweet en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 181-187 Título : Pharmacologic profile of perphenazine's metabolites Tipo de documento: texto impreso Autores: Robert A. Sweet, Autor ; Bruce G. Pollock, Autor ; Benoit H. Mulsant, Autor Fecha de publicación: 2023 Artículo en la página: pp. 181-187 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Efectos cerebrales, Demencia, Antagonistas de la dopamina, Perfenazina. Resumen: The authors have previously reported that in elderly patients treated with low doses of perphenazine, few extrapyramidal symptoms (EPS) developed in those who were not poor CYP2D6 metabolizers. The authors hypothesized that this atypical side effect profile is due to perphenazine's principal metabolite, n-dealkylperphenazine (DAPZ), which is usually present in vivo at concentrations 1.5 to 2 times that of the parent drug. Link: ./index.php?lvl=notice_display&id=31213 [artículo] Pharmacologic profile of perphenazine's metabolites [texto impreso] / Robert A. Sweet, Autor ; Bruce G. Pollock, Autor ; Benoit H. Mulsant, Autor . - 2023 . - pp. 181-187. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 181-187 Palabras clave: Antipsicóticos, Efectos cerebrales, Demencia, Antagonistas de la dopamina, Perfenazina. Resumen: The authors have previously reported that in elderly patients treated with low doses of perphenazine, few extrapyramidal symptoms (EPS) developed in those who were not poor CYP2D6 metabolizers. The authors hypothesized that this atypical side effect profile is due to perphenazine's principal metabolite, n-dealkylperphenazine (DAPZ), which is usually present in vivo at concentrations 1.5 to 2 times that of the parent drug. Link: ./index.php?lvl=notice_display&id=31213

Tardive dyskinesia associated with higher mortality in psychiatric patients: results of a meta-analysis of seven independent studies / Javier Ballesteros en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 188-194 Título : Tardive dyskinesia associated with higher mortality in psychiatric patients: results of a meta-analysis of seven independent studies Tipo de documento: texto impreso Autores: Javier Ballesteros, Autor ; Asunción González Pinto, Autor ; Antonio Bulbena Vilarrasa, Autor Fecha de publicación: 2023 Artículo en la página: pp. 188-194 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Causa de muerte, Discinesia inducida por fármacos, Trastornos psicóticos. Resumen: This article reports a meta-analysis of seven independent studies on the association of tardive dyskinesia with all-cause mortality in psychiatric patients. Most of the studies included provide either small sample sizes or follow-up periods too short to reach a substantive conclusion on their own. Link: ./index.php?lvl=notice_display&id=31214 [artículo] Tardive dyskinesia associated with higher mortality in psychiatric patients: results of a meta-analysis of seven independent studies [texto impreso] / Javier Ballesteros, Autor ; Asunción González Pinto, Autor ; Antonio Bulbena Vilarrasa, Autor . - 2023 . - pp. 188-194. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 188-194 Palabras clave: Antipsicóticos, Causa de muerte, Discinesia inducida por fármacos, Trastornos psicóticos. Resumen: This article reports a meta-analysis of seven independent studies on the association of tardive dyskinesia with all-cause mortality in psychiatric patients. Most of the studies included provide either small sample sizes or follow-up periods too short to reach a substantive conclusion on their own. Link: ./index.php?lvl=notice_display&id=31214

Valproate as an adjunct to neuroleptic medication for the treatment of acute episodes of mania: a prospective, randomized, double-blind, placebo-controlled, multicenter study / Bruno Müller Oerlinghausen en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 195-203 Título : Valproate as an adjunct to neuroleptic medication for the treatment of acute episodes of mania: a prospective, randomized, double-blind, placebo-controlled, multicenter study Tipo de documento: texto impreso Autores: Bruno Müller Oerlinghausen, Autor ; Angelika Retzow, Autor ; Fritz A. Henn, Autor Fecha de publicación: 2023 Artículo en la página: pp. 195-203 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Trastorno bipolar, Haloperidol, Perazina, Ácido Valproico Resumen: To compare the efficacy of sodium valproate administered as adjunct to neuroleptic medication for patients with acute mania with the efficacy of neuroleptics alone, the authors conducted a 21-day, randomized, double-blind, parallel-group, placebo-controlled trial. The study design closely reflected a clinical psychiatric setting in Europe where patients with acute mania commonly receive neuroleptic medication. Link: ./index.php?lvl=notice_display&id=31215 [artículo] Valproate as an adjunct to neuroleptic medication for the treatment of acute episodes of mania: a prospective, randomized, double-blind, placebo-controlled, multicenter study [texto impreso] / Bruno Müller Oerlinghausen, Autor ; Angelika Retzow, Autor ; Fritz A. Henn, Autor . - 2023 . - pp. 195-203. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 195-203 Palabras clave: Antipsicóticos, Trastorno bipolar, Haloperidol, Perazina, Ácido Valproico Resumen: To compare the efficacy of sodium valproate administered as adjunct to neuroleptic medication for patients with acute mania with the efficacy of neuroleptics alone, the authors conducted a 21-day, randomized, double-blind, parallel-group, placebo-controlled trial. The study design closely reflected a clinical psychiatric setting in Europe where patients with acute mania commonly receive neuroleptic medication. Link: ./index.php?lvl=notice_display&id=31215

Thyroid function and psychiatric morbidity in patients with manic disorder receiving lithium therapy / Sing Lee en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 204-209 Título : Thyroid function and psychiatric morbidity in patients with manic disorder receiving lithium therapy Tipo de documento: texto impreso Autores: Sing Lee, Autor ; Chun C. Chow, Autor ; Yun K. Wingrove, Autor Fecha de publicación: 2023 Artículo en la página: pp. 204-209 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno bipolar, Síndromes de enfermedad eutiroidea, Hipertiroxinemia, Carbonato de Litio, Pruebas de función tiroidea, Tirotropina. Resumen: Euthyroid hyperthyroxinemia as a result of a transient increase in thyroid-stimulating hormone (TSH) levels may contribute to the development of manic disorder. Lithium has a potent short-term antithyroidal effect that may account for its antimanic action. Link: ./index.php?lvl=notice_display&id=31216 [artículo] Thyroid function and psychiatric morbidity in patients with manic disorder receiving lithium therapy [texto impreso] / Sing Lee, Autor ; Chun C. Chow, Autor ; Yun K. Wingrove, Autor . - 2023 . - pp. 204-209. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 204-209 Palabras clave: Trastorno bipolar, Síndromes de enfermedad eutiroidea, Hipertiroxinemia, Carbonato de Litio, Pruebas de función tiroidea, Tirotropina. Resumen: Euthyroid hyperthyroxinemia as a result of a transient increase in thyroid-stimulating hormone (TSH) levels may contribute to the development of manic disorder. Lithium has a potent short-term antithyroidal effect that may account for its antimanic action. Link: ./index.php?lvl=notice_display&id=31216

Disposition of haloperidol pyridinium and reduced haloperidol pyridinium in schizophrenic patients: no relationship with clinical variables during short-term treatment / Sven Ulrich en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 210-219 Título : Disposition of haloperidol pyridinium and reduced haloperidol pyridinium in schizophrenic patients: no relationship with clinical variables during short-term treatment Tipo de documento: texto impreso Autores: Sven Ulrich, Autor ; Sabine Neuhof, Autor ; Verena Braun, Autor Fecha de publicación: 2023 Artículo en la página: pp. 210-219 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Haloperidol, Compuestos de piridinio, Esquizofrenia. Resumen: In an open clinical trial, serum concentrations of haloperidol pyridinium (CHP+) and reduced haloperidol pyridinium (CRHP+), as well as haloperidol (CH) and reduced haloperidol (CRH), were measured in 57 schizophrenic and schizoaffective inpatients during 6 weeks of short-term treatment. Psychopathology was monitored with the Brief Psychiatric Rating Scale (BPRS), and extrapyramidal adverse effects were assessed with the Extrapyramidal Symptom Rating Scale (EPS). Link: ./index.php?lvl=notice_display&id=31217 [artículo] Disposition of haloperidol pyridinium and reduced haloperidol pyridinium in schizophrenic patients: no relationship with clinical variables during short-term treatment [texto impreso] / Sven Ulrich, Autor ; Sabine Neuhof, Autor ; Verena Braun, Autor . - 2023 . - pp. 210-219. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 210-219 Palabras clave: Antipsicóticos, Haloperidol, Compuestos de piridinio, Esquizofrenia. Resumen: In an open clinical trial, serum concentrations of haloperidol pyridinium (CHP+) and reduced haloperidol pyridinium (CRHP+), as well as haloperidol (CH) and reduced haloperidol (CRH), were measured in 57 schizophrenic and schizoaffective inpatients during 6 weeks of short-term treatment. Psychopathology was monitored with the Brief Psychiatric Rating Scale (BPRS), and extrapyramidal adverse effects were assessed with the Extrapyramidal Symptom Rating Scale (EPS). Link: ./index.php?lvl=notice_display&id=31217

Olanzapine pharmacokinetics in pediatric and adolescent inpatients with childhood-onset schizophrenia / Dale R. Grothe en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 220-225 Título : Olanzapine pharmacokinetics in pediatric and adolescent inpatients with childhood-onset schizophrenia Tipo de documento: texto impreso Autores: Dale R. Grothe, Autor ; Karim A. Calis, Autor ; Leslie K. Jacobsen, Autor Fecha de publicación: 2023 Artículo en la página: pp. 220-225 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Admisión de pacientes, Pirenzepina, Esquizofrenia. Resumen: Well-designed studies investigating how pediatric or adolescent patients with mental disorders respond to and metabolize the newer antipsychotic drugs are practically nonexistent. Without such data, clinicians have difficulty designing appropriate dosage regimens for patients in these age groups. Link: ./index.php?lvl=notice_display&id=31218 [artículo] Olanzapine pharmacokinetics in pediatric and adolescent inpatients with childhood-onset schizophrenia [texto impreso] / Dale R. Grothe, Autor ; Karim A. Calis, Autor ; Leslie K. Jacobsen, Autor . - 2023 . - pp. 220-225. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 220-225 Palabras clave: Antipsicóticos, Admisión de pacientes, Pirenzepina, Esquizofrenia. Resumen: Well-designed studies investigating how pediatric or adolescent patients with mental disorders respond to and metabolize the newer antipsychotic drugs are practically nonexistent. Without such data, clinicians have difficulty designing appropriate dosage regimens for patients in these age groups. Link: ./index.php?lvl=notice_display&id=31218

Effects of lorazepam on emotional reactivity, performance, and vigilance in subjects with high or low anxiety / Christine Garcia en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 226-233 Título : Effects of lorazepam on emotional reactivity, performance, and vigilance in subjects with high or low anxiety Tipo de documento: texto impreso Autores: Christine Garcia, Autor ; Joelle Micallef, Autor ; Diane Dubreuil, Autor Fecha de publicación: 2023 Artículo en la página: pp. 226-233 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Ansiolíticos, Trastornos de ansiedad, Emociones - efectos del medicamento, Lorazepam, Pruebas neuropsicológicas Resumen: This study examined the hypothesis that low doses of lorazepam modify emotional response. In accord with the results of prior studies that suggest a differential effect of benzodiazepines according to the subjects' anxiety level, the authors tested the effect of lorazepam (0.5 mg twice daily) on 2 groups of 32 subjects: those with high anxiety (HA) and those with low anxiety (LA). Link: ./index.php?lvl=notice_display&id=31219 [artículo] Effects of lorazepam on emotional reactivity, performance, and vigilance in subjects with high or low anxiety [texto impreso] / Christine Garcia, Autor ; Joelle Micallef, Autor ; Diane Dubreuil, Autor . - 2023 . - pp. 226-233. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 226-233 Palabras clave: Ansiolíticos, Trastornos de ansiedad, Emociones - efectos del medicamento, Lorazepam, Pruebas neuropsicológicas Resumen: This study examined the hypothesis that low doses of lorazepam modify emotional response. In accord with the results of prior studies that suggest a differential effect of benzodiazepines according to the subjects' anxiety level, the authors tested the effect of lorazepam (0.5 mg twice daily) on 2 groups of 32 subjects: those with high anxiety (HA) and those with low anxiety (LA). Link: ./index.php?lvl=notice_display&id=31219

Oxidative and nonoxidative benzodiazepines and the risk of femur fracture. The systematic assessment of geriatric drug use via epidemiology study group / Antonio Sgadari en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 234-239 Título : Oxidative and nonoxidative benzodiazepines and the risk of femur fracture. The systematic assessment of geriatric drug use via epidemiology study group Tipo de documento: texto impreso Autores: Antonio Sgadari, Autor ; Kate L. Lapane, Autor ; Vincent Mor, Autor Fecha de publicación: 2023 Artículo en la página: pp. 234-239 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Ansiolíticos, Benzodiazepinas, Fracturas femorales, Ancianos - fragilidad, Geriátrica, Hogares geriátricos. Resumen: Benzodiazepine use is a well-identified risk factor for falls and the resulting femur fractures in elderly adults. Benzodiazepines not requiring hepatic biotransformation may be safer than agents undergoing oxidation because oxidative activity has been shown to decline with age. The association between the use of either oxidative or nonoxidative benzodiazepines and the risk of femur fracture among elderly adults living in nursing homes was studied. Link: ./index.php?lvl=notice_display&id=31220 [artículo] Oxidative and nonoxidative benzodiazepines and the risk of femur fracture. The systematic assessment of geriatric drug use via epidemiology study group [texto impreso] / Antonio Sgadari, Autor ; Kate L. Lapane, Autor ; Vincent Mor, Autor . - 2023 . - pp. 234-239. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 234-239 Palabras clave: Ansiolíticos, Benzodiazepinas, Fracturas femorales, Ancianos - fragilidad, Geriátrica, Hogares geriátricos. Resumen: Benzodiazepine use is a well-identified risk factor for falls and the resulting femur fractures in elderly adults. Benzodiazepines not requiring hepatic biotransformation may be safer than agents undergoing oxidation because oxidative activity has been shown to decline with age. The association between the use of either oxidative or nonoxidative benzodiazepines and the risk of femur fracture among elderly adults living in nursing homes was studied. Link: ./index.php?lvl=notice_display&id=31220

Subject selection for the placebo- and comparator-controlled trials of neuroleptics in schizophrenia / Pavel Mohr en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 240-245 Título : Subject selection for the placebo- and comparator-controlled trials of neuroleptics in schizophrenia Tipo de documento: texto impreso Autores: Pavel Mohr, Autor ; Pál Czobor, Autor Fecha de publicación: 2023 Artículo en la página: pp. 240-245 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Diseño de investigación, Esquizofrenia. Resumen: It has been suggested that inclusion of a placebo treatment arm in controlled clinical trials might bias the selection of study subjects. Presumably, patients in the placebo-controlled studies are more stable, but there are no data available to support such an assumption. The authors tested the hypothesis in a set of randomized trials of neuroleptics in treating schizophrenia by comparing placebo-controlled (PCTs) and comparator-controlled trials (CCTs) in terms of basic patient characteristics. Link: ./index.php?lvl=notice_display&id=31221 [artículo] Subject selection for the placebo- and comparator-controlled trials of neuroleptics in schizophrenia [texto impreso] / Pavel Mohr, Autor ; Pál Czobor, Autor . - 2023 . - pp. 240-245. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 240-245 Palabras clave: Antipsicóticos, Diseño de investigación, Esquizofrenia. Resumen: It has been suggested that inclusion of a placebo treatment arm in controlled clinical trials might bias the selection of study subjects. Presumably, patients in the placebo-controlled studies are more stable, but there are no data available to support such an assumption. The authors tested the hypothesis in a set of randomized trials of neuroleptics in treating schizophrenia by comparing placebo-controlled (PCTs) and comparator-controlled trials (CCTs) in terms of basic patient characteristics. Link: ./index.php?lvl=notice_display&id=31221

Extension of a pilot study: impact from the cytochrome p450 2d6 polymorphism on outcome and costs associated with severe mental illness / Wen Hwei Chou en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 246-251 Título : Extension of a pilot study: impact from the cytochrome p450 2d6 polymorphism on outcome and costs associated with severe mental illness Tipo de documento: texto impreso Autores: Wen Hwei Chou, Autor ; Feng Xiang Yan, Autor ; Jose de Leon, Autor Fecha de publicación: 2023 Artículo en la página: pp. 246-251 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Citocromo P-450 CYP2D6, Duración de la estancia, Examen neurológico, Trastornos psicóticos. Resumen: The influence of cytochrome P450 2D6 (CYP2D6) genetic variability was examined in psychiatric inpatients by evaluating adverse drug events (ADEs), hospital stays, and total costs over a 1-year period in an extension of a previously published brief report. One hundred consecutive psychiatric patients from Eastern State Hospital in Lexington, Kentucky, were genotyped for CYP2D6 expression. Link: ./index.php?lvl=notice_display&id=31222 [artículo] Extension of a pilot study: impact from the cytochrome p450 2d6 polymorphism on outcome and costs associated with severe mental illness [texto impreso] / Wen Hwei Chou, Autor ; Feng Xiang Yan, Autor ; Jose de Leon, Autor . - 2023 . - pp. 246-251. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 246-251 Palabras clave: Antipsicóticos, Citocromo P-450 CYP2D6, Duración de la estancia, Examen neurológico, Trastornos psicóticos. Resumen: The influence of cytochrome P450 2D6 (CYP2D6) genetic variability was examined in psychiatric inpatients by evaluating adverse drug events (ADEs), hospital stays, and total costs over a 1-year period in an extension of a previously published brief report. One hundred consecutive psychiatric patients from Eastern State Hospital in Lexington, Kentucky, were genotyped for CYP2D6 expression. Link: ./index.php?lvl=notice_display&id=31222