Artículos

Vaccines as immunotherapies for substance use disorders / Thomas R. Kosten en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 362–371 Título : Vaccines as immunotherapies for substance use disorders Tipo de documento: texto impreso Autores: Thomas R. Kosten, Autor Fecha de publicación: 2025 Artículo en la página: pp. 362–371 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Función inmune, Nicotina, Opioides, Farmacoterapia, Estimulantes, Trastornos relacionados con sustancias y adictivos. Resumen: Substance use disorders (SUD) present a worldwide challenge with few effective therapies except for the relative efficacy of opioid pharmacotherapies, despite limited treatment access. However, the proliferation of illicit fentanyl use initiated a dramatic and cascading epidemic of lethal overdoses. Link: ./index.php?lvl=notice_display&id=31501 [artículo] Vaccines as immunotherapies for substance use disorders [texto impreso] / Thomas R. Kosten, Autor . - 2025 . - pp. 362–371. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 362–371 Palabras clave: Función inmune, Nicotina, Opioides, Farmacoterapia, Estimulantes, Trastornos relacionados con sustancias y adictivos. Resumen: Substance use disorders (SUD) present a worldwide challenge with few effective therapies except for the relative efficacy of opioid pharmacotherapies, despite limited treatment access. However, the proliferation of illicit fentanyl use initiated a dramatic and cascading epidemic of lethal overdoses. Link: ./index.php?lvl=notice_display&id=31501

Harm reduction for opioid use disorder: strategies and outcome metrics / Jennifer D. Ellis en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 372-380 Título : Harm reduction for opioid use disorder: strategies and outcome metrics Tipo de documento: texto impreso Autores: Jennifer D. Ellis, Autor ; Kelly E. Dunn, Autor ; Andrew S. Huhn, Autor Fecha de publicación: 2025 Artículo en la página: pp. 372-380 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Psiquiatría de adicciones, Reducción de daños, No abstinencia, Trastorno por consumo de opioides, Opiáceos, Trastornos adictivos y relacionados con sustancias. Resumen: Opioid overdose deaths and opioid-related harms have reached unprecedented levels, particularly as compounds such as xylazine and fentanyl have infiltrated the drug supply. Harm reduction strategies are especially relevant in this climate, as they aim to reduce drug-related harms independently of whether an individual chooses to enter treatment or abstain from opioid use. Link: ./index.php?lvl=notice_display&id=31502 [artículo] Harm reduction for opioid use disorder: strategies and outcome metrics [texto impreso] / Jennifer D. Ellis, Autor ; Kelly E. Dunn, Autor ; Andrew S. Huhn, Autor . - 2025 . - pp. 372-380. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 372-380 Palabras clave: Psiquiatría de adicciones, Reducción de daños, No abstinencia, Trastorno por consumo de opioides, Opiáceos, Trastornos adictivos y relacionados con sustancias. Resumen: Opioid overdose deaths and opioid-related harms have reached unprecedented levels, particularly as compounds such as xylazine and fentanyl have infiltrated the drug supply. Harm reduction strategies are especially relevant in this climate, as they aim to reduce drug-related harms independently of whether an individual chooses to enter treatment or abstain from opioid use. Link: ./index.php?lvl=notice_display&id=31502

Understanding and addressing widening racial inequalities in drug overdose / Joseph R. Friedman en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 381-390 Título : Understanding and addressing widening racial inequalities in drug overdose Tipo de documento: texto impreso Autores: Joseph R. Friedman, Autor Fecha de publicación: 2025 Artículo en la página: pp. 381-390 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Disparidades, Opiáceos, Trastornos relacionados con sustancias y adictivos. Resumen: The fourth wave of the United States overdose crisis—driven by the polysubstance use of fentanyl with stimulants and other synthetic substances—has driven sharply escalating racial/ethnic inequalities in drug overdose death rates. Here the authors present a detailed portrait of the latest overdose trends and synthesize the literature to describe where, how, and why these inequalities are worsening. Link: ./index.php?lvl=notice_display&id=31503 [artículo] Understanding and addressing widening racial inequalities in drug overdose [texto impreso] / Joseph R. Friedman, Autor . - 2025 . - pp. 381-390. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 381-390 Palabras clave: Disparidades, Opiáceos, Trastornos relacionados con sustancias y adictivos. Resumen: The fourth wave of the United States overdose crisis—driven by the polysubstance use of fentanyl with stimulants and other synthetic substances—has driven sharply escalating racial/ethnic inequalities in drug overdose death rates. Here the authors present a detailed portrait of the latest overdose trends and synthesize the literature to describe where, how, and why these inequalities are worsening. Link: ./index.php?lvl=notice_display&id=31503

Alcohol use disorder and chronic pain: an overlooked epidemic / Joao P. De Aquino en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 391-402 Título : Alcohol use disorder and chronic pain: an overlooked epidemic Tipo de documento: texto impreso Autores: Joao P. De Aquino, Autor ; Matthew E. Sloan, Autor Fecha de publicación: 2025 Artículo en la página: pp. 391-402 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Alcohol, Intoxicación por alcohol, Trastorno por consumo de alcohol, Abstinencia de alcohol, Analgésicos, Dolor crónico, Dolor, Medición del dolor, Trastornos relacionados con sustancias y adictivos. Resumen: Alcohol use disorder (AUD) and chronic pain disorders are pervasive, multifaceted medical conditions that often co-occur. However, their comorbidity is often overlooked, despite its prevalence and clinical relevance. Individuals with AUD are more likely to experience chronic pain than the general population. Conversely, individuals with chronic pain commonly alleviate their pain with alcohol, which may escalate into AUD. Link: ./index.php?lvl=notice_display&id=31504 [artículo] Alcohol use disorder and chronic pain: an overlooked epidemic [texto impreso] / Joao P. De Aquino, Autor ; Matthew E. Sloan, Autor . - 2025 . - pp. 391-402. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 391-402 Palabras clave: Alcohol, Intoxicación por alcohol, Trastorno por consumo de alcohol, Abstinencia de alcohol, Analgésicos, Dolor crónico, Dolor, Medición del dolor, Trastornos relacionados con sustancias y adictivos. Resumen: Alcohol use disorder (AUD) and chronic pain disorders are pervasive, multifaceted medical conditions that often co-occur. However, their comorbidity is often overlooked, despite its prevalence and clinical relevance. Individuals with AUD are more likely to experience chronic pain than the general population. Conversely, individuals with chronic pain commonly alleviate their pain with alcohol, which may escalate into AUD. Link: ./index.php?lvl=notice_display&id=31504

Topiramate versus naltrexone for alcohol use disorder: a genotype-stratified double-blind randomized controlled trial / Kirsten C. Morley en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 403-411 Título : Topiramate versus naltrexone for alcohol use disorder: a genotype-stratified double-blind randomized controlled trial Tipo de documento: texto impreso Autores: Kirsten C. Morley, Autor ; Henry R. Kranzler, Autor Fecha de publicación: 2025 Artículo en la página: pp. 403-411 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno por consumo de alcohol, GRIK1, Naltrexona, OPRM1, Farmacogenética, Topiramato. Resumen: There have been no well-controlled and well-powered comparative trials of topiramate with other pharmacotherapies for alcohol use disorder (AUD), such as naltrexone. Moreover, the literature is mixed on the effects of two polymorphisms—rs2832407 (in GRIK1) and rs1799971 (in OPRM1)—on response to topiramate and naltrexone, respectively. Link: ./index.php?lvl=notice_display&id=31505 [artículo] Topiramate versus naltrexone for alcohol use disorder: a genotype-stratified double-blind randomized controlled trial [texto impreso] / Kirsten C. Morley, Autor ; Henry R. Kranzler, Autor . - 2025 . - pp. 403-411. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 403-411 Palabras clave: Trastorno por consumo de alcohol, GRIK1, Naltrexona, OPRM1, Farmacogenética, Topiramato. Resumen: There have been no well-controlled and well-powered comparative trials of topiramate with other pharmacotherapies for alcohol use disorder (AUD), such as naltrexone. Moreover, the literature is mixed on the effects of two polymorphisms—rs2832407 (in GRIK1) and rs1799971 (in OPRM1)—on response to topiramate and naltrexone, respectively. Link: ./index.php?lvl=notice_display&id=31505

Neural correlates of stress and alcohol cue-induced alcohol craving and of future heavy drinking: evidence of sex differences / Milena Radoman en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 412-422 Título : Neural correlates of stress and alcohol cue-induced alcohol craving and of future heavy drinking: evidence of sex differences Tipo de documento: texto impreso Autores: Milena Radoman, Autor ; Nia Fogelman, Autor ; Cheryl Lacadie, Autor Fecha de publicación: 2025 Artículo en la página: pp. 412-422 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Alcohol, Reactividad de señales, Neuroimagen, Diferencias sexuales, Estrés, Trastornos adictivos y relacionados con sustancias. Resumen: Stress and alcohol cue reactivity are associated with poor treatment outcomes in alcohol use disorder (AUD), but sex-specific neural correlates of stress and alcohol cue–induced craving compared with neutral cue–induced craving and of heavy drinking outcomes in AUD have not been examined. Thus, this study prospectively examined these associations and assessed sex differences. Link: ./index.php?lvl=notice_display&id=31506 [artículo] Neural correlates of stress and alcohol cue-induced alcohol craving and of future heavy drinking: evidence of sex differences [texto impreso] / Milena Radoman, Autor ; Nia Fogelman, Autor ; Cheryl Lacadie, Autor . - 2025 . - pp. 412-422. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 412-422 Palabras clave: Alcohol, Reactividad de señales, Neuroimagen, Diferencias sexuales, Estrés, Trastornos adictivos y relacionados con sustancias. Resumen: Stress and alcohol cue reactivity are associated with poor treatment outcomes in alcohol use disorder (AUD), but sex-specific neural correlates of stress and alcohol cue–induced craving compared with neutral cue–induced craving and of heavy drinking outcomes in AUD have not been examined. Thus, this study prospectively examined these associations and assessed sex differences. Link: ./index.php?lvl=notice_display&id=31506

Predictors of substance use initiation by early adolescence / ReJoyce Green en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 423-433 Título : Predictors of substance use initiation by early adolescence Tipo de documento: texto impreso Autores: ReJoyce Green, Autor ; Bethany J. Wolf, Autor ; Andrew Chen, Autor Fecha de publicación: 2025 Artículo en la página: pp. 423-433 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Psiquiatría infantil y adolescente, Desarrollo, Trastornos adictivos y relacionados con sustancias. Resumen: Substance use initiation during early adolescence is associated with later development of substance use and mental health disorders. This study used various domains to predict substance use initiation, defined as trying any nonprescribed substance (e.g., alcohol, tobacco, cannabis), by age 12, using a large longitudinal data set. Link: ./index.php?lvl=notice_display&id=31507 [artículo] Predictors of substance use initiation by early adolescence [texto impreso] / ReJoyce Green, Autor ; Bethany J. Wolf, Autor ; Andrew Chen, Autor . - 2025 . - pp. 423-433. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 423-433 Palabras clave: Psiquiatría infantil y adolescente, Desarrollo, Trastornos adictivos y relacionados con sustancias. Resumen: Substance use initiation during early adolescence is associated with later development of substance use and mental health disorders. This study used various domains to predict substance use initiation, defined as trying any nonprescribed substance (e.g., alcohol, tobacco, cannabis), by age 12, using a large longitudinal data set. Link: ./index.php?lvl=notice_display&id=31507

Associations between a primary care-delivered alcohol-related brief intervention and subsequent opioid-related outcomes / Dan V. Blalock en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 434-444 Título : Associations between a primary care-delivered alcohol-related brief intervention and subsequent opioid-related outcomes Tipo de documento: texto impreso Autores: Dan V. Blalock, Autor ; Sophia A. Berlin, Autor ; Theodore Berkowitz, Autor Fecha de publicación: 2025 Artículo en la página: pp. 434-444 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Alcohol, Sistemas de prestación de servicios y atención de salud mental, Opiáceos, Trastornos adictivos y relacionados con sustancias. Resumen: The co-occurrence of unhealthy alcohol use and opioid misuse is high and associated with increased rates of overdose, emergency health care utilization, and death. The current study examined whether receipt of an alcohol-related brief intervention is associated with reduced risk of negative downstream opioid-related outcomes. Link: ./index.php?lvl=notice_display&id=31508 [artículo] Associations between a primary care-delivered alcohol-related brief intervention and subsequent opioid-related outcomes [texto impreso] / Dan V. Blalock, Autor ; Sophia A. Berlin, Autor ; Theodore Berkowitz, Autor . - 2025 . - pp. 434-444. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 434-444 Palabras clave: Alcohol, Sistemas de prestación de servicios y atención de salud mental, Opiáceos, Trastornos adictivos y relacionados con sustancias. Resumen: The co-occurrence of unhealthy alcohol use and opioid misuse is high and associated with increased rates of overdose, emergency health care utilization, and death. The current study examined whether receipt of an alcohol-related brief intervention is associated with reduced risk of negative downstream opioid-related outcomes. Link: ./index.php?lvl=notice_display&id=31508

Associations of menstrual cycle and progesterone-to-estradiol ratio with alcohol consumption in alcohol use disorder: a sex-separated multicenter longitudinal study / Sabine Hoffmann en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 445-456 Título : Associations of menstrual cycle and progesterone-to-estradiol ratio with alcohol consumption in alcohol use disorder: a sex-separated multicenter longitudinal study Tipo de documento: texto impreso Autores: Sabine Hoffmann, Autor ; Sarah Gerhardt, Autor ; Christiane Mühle, Autor Fecha de publicación: 2025 Artículo en la página: pp. 445-456 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Psiquiatría de las adicciones, Trastorno por consumo de alcohol, Evaluación ecológica momentánea, Progesterona, Estradiol, Trastornos adictivos y relacionados con sustancias. Resumen: Alcohol use disorder (AUD) constitutes a critical public health issue and has sex-specific characteristics. Initial evidence suggests that progesterone and estradiol might reduce or increase alcohol intake, respectively. However, there is a need for a better understanding of how the menstrual cycle in females and the ratio of progesterone to estradiol in females and males influence alcohol use patterns in individuals with AUD. Link: ./index.php?lvl=notice_display&id=31509 [artículo] Associations of menstrual cycle and progesterone-to-estradiol ratio with alcohol consumption in alcohol use disorder: a sex-separated multicenter longitudinal study [texto impreso] / Sabine Hoffmann, Autor ; Sarah Gerhardt, Autor ; Christiane Mühle, Autor . - 2025 . - pp. 445-456. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 5 (Mayo) . - pp. 445-456 Palabras clave: Psiquiatría de las adicciones, Trastorno por consumo de alcohol, Evaluación ecológica momentánea, Progesterona, Estradiol, Trastornos adictivos y relacionados con sustancias. Resumen: Alcohol use disorder (AUD) constitutes a critical public health issue and has sex-specific characteristics. Initial evidence suggests that progesterone and estradiol might reduce or increase alcohol intake, respectively. However, there is a need for a better understanding of how the menstrual cycle in females and the ratio of progesterone to estradiol in females and males influence alcohol use patterns in individuals with AUD. Link: ./index.php?lvl=notice_display&id=31509