Artículos

Pharmacogenomic clinical support tools for the treatment of depression / Matthew L. Baum en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 591-607 Título : Pharmacogenomic clinical support tools for the treatment of depression Tipo de documento: texto impreso Autores: Matthew L. Baum, Autor ; Alik S. Widge, Autor ; Linda L. Carpenter, Autor Fecha de publicación: 2025 Artículo en la página: pp. 591-607 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Marcadores biológicos, Estudios clínicos de fármacos, Trastornos depresivos, Trastorno depresivo mayor. Resumen: In this review, the authors update the 2018 position statement of the American Psychiatric Association Council of Research Workgroup on Biomarkers and Novel Treatments on pharmacogenomic (PGx) tools for treatment selection in depression. Link: ./index.php?lvl=notice_display&id=31511 [artículo] Pharmacogenomic clinical support tools for the treatment of depression [texto impreso] / Matthew L. Baum, Autor ; Alik S. Widge, Autor ; Linda L. Carpenter, Autor . - 2025 . - pp. 591-607. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 591-607 Palabras clave: Antidepresivos, Marcadores biológicos, Estudios clínicos de fármacos, Trastornos depresivos, Trastorno depresivo mayor. Resumen: In this review, the authors update the 2018 position statement of the American Psychiatric Association Council of Research Workgroup on Biomarkers and Novel Treatments on pharmacogenomic (PGx) tools for treatment selection in depression. Link: ./index.php?lvl=notice_display&id=31511

Genome-wide association study of treatment-resistant depression: shared biology with metabolic traits / JooEun Kang en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 608-619 Título : Genome-wide association study of treatment-resistant depression: shared biology with metabolic traits Tipo de documento: texto impreso Autores: JooEun Kang, Autor ; Victor M. Castro, Autor ; Michael Ripperger, Autor Fecha de publicación: 2025 Artículo en la página: pp. 608-619 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos depresivos, Terapia electroconvulsiva (TEC), Genética - Genómica, Trastorno depresivo mayor, Depresión resistente al tratamiento. Resumen: Treatment-resistant depression (TRD) occurs in roughly one-third of all individuals with major depressive disorder (MDD). Although research has suggested a significant common variant genetic component of liability to TRD, with heritability estimated at 8% when compared with non-treatment-resistant MDD, no replicated genetic loci have been identified, and the genetic architecture of TRD remains unclear. Link: ./index.php?lvl=notice_display&id=31512 [artículo] Genome-wide association study of treatment-resistant depression: shared biology with metabolic traits [texto impreso] / JooEun Kang, Autor ; Victor M. Castro, Autor ; Michael Ripperger, Autor . - 2025 . - pp. 608-619. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 608-619 Palabras clave: Trastornos depresivos, Terapia electroconvulsiva (TEC), Genética - Genómica, Trastorno depresivo mayor, Depresión resistente al tratamiento. Resumen: Treatment-resistant depression (TRD) occurs in roughly one-third of all individuals with major depressive disorder (MDD). Although research has suggested a significant common variant genetic component of liability to TRD, with heritability estimated at 8% when compared with non-treatment-resistant MDD, no replicated genetic loci have been identified, and the genetic architecture of TRD remains unclear. Link: ./index.php?lvl=notice_display&id=31512

Association of occupational dysfunction and hospital admissions with different polygenic profiles in bipolar disorder / Lina Jonsson en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 620-629 Título : Association of occupational dysfunction and hospital admissions with different polygenic profiles in bipolar disorder Tipo de documento: texto impreso Autores: Lina Jonsson, Autor ; Elin Hörbeck, Autor ; Amedeo Primerano, Autor Fecha de publicación: 2025 Artículo en la página: pp. 620-629 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno por déficit de atención e hiperactividad, Trastornos bipolares, Genética - genómica, Funcionamiento ocupacional, Puntuaciones de riesgo poligénico, Esquizofrenia. Resumen: Many but not all persons with bipolar disorder require hospital care because of severe mood episodes. Likewise, some but not all patients experience long-term occupational dysfunction that extends beyond acute mood episodes. It is not known whether these dissimilar outcomes of bipolar disorder are driven by different polygenic profiles. Link: ./index.php?lvl=notice_display&id=31513 [artículo] Association of occupational dysfunction and hospital admissions with different polygenic profiles in bipolar disorder [texto impreso] / Lina Jonsson, Autor ; Elin Hörbeck, Autor ; Amedeo Primerano, Autor . - 2025 . - pp. 620-629. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 620-629 Palabras clave: Trastorno por déficit de atención e hiperactividad, Trastornos bipolares, Genética - genómica, Funcionamiento ocupacional, Puntuaciones de riesgo poligénico, Esquizofrenia. Resumen: Many but not all persons with bipolar disorder require hospital care because of severe mood episodes. Likewise, some but not all patients experience long-term occupational dysfunction that extends beyond acute mood episodes. It is not known whether these dissimilar outcomes of bipolar disorder are driven by different polygenic profiles. Link: ./index.php?lvl=notice_display&id=31513

A Nationwide target trial emulation assessing the risk of antidepressant-induced mania among patients with bipolar depression / Christopher Rohde en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 630–638 Título : A Nationwide target trial emulation assessing the risk of antidepressant-induced mania among patients with bipolar depression Tipo de documento: texto impreso Autores: Christopher Rohde, Autor ; Østergaard, Søren D., Autor ; Oskar Hougaard Jefsen, Autor Fecha de publicación: 2025 Artículo en la página: pp. 630–638 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Trastorno bipolar y trastornos relacionados, Epidemiología, Manía, Farmacoterapia, Emulación de ensayo de destino. Resumen: Antidepressants are commonly used to treat bipolar depression but may increase the risk of mania. The evidence from randomized controlled trials, however, is limited by short treatment durations, providing little evidence for the long-term risk of antidepressant-induced mania. Link: ./index.php?lvl=notice_display&id=31514 [artículo] A Nationwide target trial emulation assessing the risk of antidepressant-induced mania among patients with bipolar depression [texto impreso] / Christopher Rohde, Autor ; Østergaard, Søren D., Autor ; Oskar Hougaard Jefsen, Autor . - 2025 . - pp. 630–638. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 630–638 Palabras clave: Antidepresivos, Trastorno bipolar y trastornos relacionados, Epidemiología, Manía, Farmacoterapia, Emulación de ensayo de destino. Resumen: Antidepressants are commonly used to treat bipolar depression but may increase the risk of mania. The evidence from randomized controlled trials, however, is limited by short treatment durations, providing little evidence for the long-term risk of antidepressant-induced mania. Link: ./index.php?lvl=notice_display&id=31514

Association of lower rostral anterior cingulate gaba+ and dysregulated cortisol stress response with altered functional connectivity in young adults with lifetime depression: a multimodal imaging investigation of trait and state effects en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 639–650 Título : Association of lower rostral anterior cingulate gaba+ and dysregulated cortisol stress response with altered functional connectivity in young adults with lifetime depression: a multimodal imaging investigation of trait and state effects Tipo de documento: texto impreso Fecha de publicación: 2025 Artículo en la página: pp. 639–650 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Imágenes cerebrales, Cortisol, GABA, Trastorno depresivo mayor, Estrés. Resumen: Preclinical work suggests that excess glucocorticoids and reduced cortical γ-aminobutyric acid (GABA) may affect sex-dependent differences in brain regions implicated in stress regulation and depressive phenotypes. The authors sought to address a critical gap in knowledge, namely, how stress circuitry is functionally affected by glucocorticoids and GABA in current or remitted major depressive disorder (MDD). Link: ./index.php?lvl=notice_display&id=31515 [artículo] Association of lower rostral anterior cingulate gaba+ and dysregulated cortisol stress response with altered functional connectivity in young adults with lifetime depression: a multimodal imaging investigation of trait and state effects [texto impreso] . - 2025 . - pp. 639–650. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 639–650 Palabras clave: Imágenes cerebrales, Cortisol, GABA, Trastorno depresivo mayor, Estrés. Resumen: Preclinical work suggests that excess glucocorticoids and reduced cortical γ-aminobutyric acid (GABA) may affect sex-dependent differences in brain regions implicated in stress regulation and depressive phenotypes. The authors sought to address a critical gap in knowledge, namely, how stress circuitry is functionally affected by glucocorticoids and GABA in current or remitted major depressive disorder (MDD). Link: ./index.php?lvl=notice_display&id=31515

Associations between general and specific mental health conditions in young adulthood and cardiometabolic complications in middle adulthood: a 40-year longitudinal familial coaggregation study of 672,823 swedish individuals / Cen Chen en The American Journal of Psychiatry, Año 2024 - Vol. 181 - No. 7 (Julio)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 651-657 Título : Associations between general and specific mental health conditions in young adulthood and cardiometabolic complications in middle adulthood: a 40-year longitudinal familial coaggregation study of 672,823 swedish individuals Tipo de documento: texto impreso Autores: Cen Chen, Autor ; Zheng Chang, Autor ; Ralf Kuja-Halkola, Autor Fecha de publicación: 2025 Artículo en la página: pp. 651-657 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Enfermedad cardiovascular, Comorbilidad, Congregación familiar, Modelo de psicopatología general, Trastornos mentales, Síndrome metabólico. Resumen: Most mental disorders, when examined individually, are associated with an increased risk of cardiometabolic complications. However, these associations might be attributed to a general liability to psychopathology or confounded by unmeasured familial factors. The authors investigated the association between psychiatric conditions in young adulthood and the risk of cardiometabolic complications in middle adulthood, up to 40 years later. Link: ./index.php?lvl=notice_display&id=31516 [artículo] Associations between general and specific mental health conditions in young adulthood and cardiometabolic complications in middle adulthood: a 40-year longitudinal familial coaggregation study of 672,823 swedish individuals [texto impreso] / Cen Chen, Autor ; Zheng Chang, Autor ; Ralf Kuja-Halkola, Autor . - 2025 . - pp. 651-657. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2024 - Vol. 181 - No. 7 (Julio) . - pp. 651-657 Palabras clave: Enfermedad cardiovascular, Comorbilidad, Congregación familiar, Modelo de psicopatología general, Trastornos mentales, Síndrome metabólico. Resumen: Most mental disorders, when examined individually, are associated with an increased risk of cardiometabolic complications. However, these associations might be attributed to a general liability to psychopathology or confounded by unmeasured familial factors. The authors investigated the association between psychiatric conditions in young adulthood and the risk of cardiometabolic complications in middle adulthood, up to 40 years later. Link: ./index.php?lvl=notice_display&id=31516