Association of missense mutation in FOLH1 with decreased NAAG levels and impaired working memory circuitry and cognition / Caroline F. Zink en The American Journal of Psychiatry, Año 2020 - Vol. 177 - No.12 (Diciembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2020 - Vol. 177 - No.12 (Diciembre) . - pp. 1129-1139 Título : Association of missense mutation in FOLH1 with decreased NAAG levels and impaired working memory circuitry and cognition Tipo de documento: texto impreso Autores: Caroline F. Zink, Autor ; Peter B. Barker, Autor ; Akira Sawa, Autor Fecha de publicación: 2021 Artículo en la página: pp. 1129-1139 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Genética, Cognición, Mutaciones, N-acetil-aspartil-glutamato Resumen: Altering the metabotropic glutamate receptor 3 (mGluR3) by pharmacology or genetics is associated with differences in learning and memory in animals and humans. GRM3 (the gene coding for mGluR3) is also genome-wide associated with risk for schizophrenia. The neurotransmitter N-acetyl-aspartyl-glutamate (NAAG) is the selective endogenous agonist of mGluR3, and increasing NAAG may improve cognition. Link: ./index.php?lvl=notice_display&id=25789 [artículo] Association of missense mutation in FOLH1 with decreased NAAG levels and impaired working memory circuitry and cognition [texto impreso] / Caroline F. Zink, Autor ; Peter B. Barker, Autor ; Akira Sawa, Autor . - 2021 . - pp. 1129-1139. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2020 - Vol. 177 - No.12 (Diciembre) . - pp. 1129-1139 Palabras clave: Genética, Cognición, Mutaciones, N-acetil-aspartil-glutamato Resumen: Altering the metabotropic glutamate receptor 3 (mGluR3) by pharmacology or genetics is associated with differences in learning and memory in animals and humans. GRM3 (the gene coding for mGluR3) is also genome-wide associated with risk for schizophrenia. The neurotransmitter N-acetyl-aspartyl-glutamate (NAAG) is the selective endogenous agonist of mGluR3, and increasing NAAG may improve cognition. Link: ./index.php?lvl=notice_display&id=25789

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