Impact of the kcnq2/3 channel opener ezogabine on reward circuit activity and clinical symptoms in depression / Laurel S. Morris en The American Journal of Psychiatry, Año 2021 - Vol. 178 - No.5 (Mayo)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2021 - Vol. 178 - No.5 (Mayo) . - pp. 437-446 Título : Impact of the kcnq2/3 channel opener ezogabine on reward circuit activity and clinical symptoms in depression : results from a randomized controlled trial Tipo de documento: texto impreso Autores: Laurel S. Morris, Autor ; Sara Costi, Autor ; Katherine A. Kirkwood, Autor Fecha de publicación: 2021 Artículo en la página: pp. 437-446 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Depresión, Antidepresivos, Anhedonia, Neuroimagen, Canal de potasio KCNQ Resumen: Preclinical studies point to the KCNQ2/3 potassium channel as a novel target for the treatment of depression and anhedonia, a reduced ability to experience pleasure. The authors conducted the first randomized placebo-controlled trial testing the effect of the KCNQ2/3 positive modulator ezogabine on reward circuit activity and clinical outcomes in patients with depression. Link: ./index.php?lvl=notice_display&id=26262 [artículo] Impact of the kcnq2/3 channel opener ezogabine on reward circuit activity and clinical symptoms in depression : results from a randomized controlled trial [texto impreso] / Laurel S. Morris, Autor ; Sara Costi, Autor ; Katherine A. Kirkwood, Autor . - 2021 . - pp. 437-446. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2021 - Vol. 178 - No.5 (Mayo) . - pp. 437-446 Palabras clave: Depresión, Antidepresivos, Anhedonia, Neuroimagen, Canal de potasio KCNQ Resumen: Preclinical studies point to the KCNQ2/3 potassium channel as a novel target for the treatment of depression and anhedonia, a reduced ability to experience pleasure. The authors conducted the first randomized placebo-controlled trial testing the effect of the KCNQ2/3 positive modulator ezogabine on reward circuit activity and clinical outcomes in patients with depression. Link: ./index.php?lvl=notice_display&id=26262

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