TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling / Dongqing Ye en European Neuropsychopharmacology, Año 2015 - Vol. 25 - No.12 (Diciembre)

Público ISBD [artículo]  inEuropean Neuropsychopharmacology > Año 2015 - Vol. 25 - No.12 (Diciembre) . - pp. 2426-2436 Título : TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling Tipo de documento: texto impreso Autores: Dongqing Ye, Autor ; Yang Li, Autor ; Xiangrong Zhang, Autor Fecha de publicación: 2021 Artículo en la página: pp. 2426-2436 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Canal de K + dependiente de mecanismo mecánico relacionado con TWIK (TREK1), Antidepresivos, SID1900, Receptor 5-HT1A, Estrés leve impredecible crónico (CUMS), Factor neurotrófico derivado del cerebro (BDNF) Resumen: Current antidepressants often remain the inadequate efficacy for many depressive patients, which warrant the necessary endeavor to develop the new molecules and targets for treating depression. Recently, the two-pore domain potassium channel TREK1 has been implicated in mood regulation and TREK-1 antagonists could be the promising antidepressant. Link: ./index.php?lvl=notice_display&id=26669 [artículo] TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling [texto impreso] / Dongqing Ye, Autor ; Yang Li, Autor ; Xiangrong Zhang, Autor . - 2021 . - pp. 2426-2436. Idioma : Inglés (eng) Idioma original : Inglés (eng) in European Neuropsychopharmacology > Año 2015 - Vol. 25 - No.12 (Diciembre) . - pp. 2426-2436 Palabras clave: Canal de K + dependiente de mecanismo mecánico relacionado con TWIK (TREK1), Antidepresivos, SID1900, Receptor 5-HT1A, Estrés leve impredecible crónico (CUMS), Factor neurotrófico derivado del cerebro (BDNF) Resumen: Current antidepressants often remain the inadequate efficacy for many depressive patients, which warrant the necessary endeavor to develop the new molecules and targets for treating depression. Recently, the two-pore domain potassium channel TREK1 has been implicated in mood regulation and TREK-1 antagonists could be the promising antidepressant. Link: ./index.php?lvl=notice_display&id=26669

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