Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist / Yukihikko Shirayama en European Neuropsychopharmacology, Año 2015 - Vol. 25 - No.12 (Diciembre)

Público ISBD [artículo]  inEuropean Neuropsychopharmacology > Año 2015 - Vol. 25 - No.12 (Diciembre) . - pp. 2449-2458 Título : Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist Tipo de documento: texto impreso Autores: Yukihikko Shirayama, Autor ; Chun Yang, Autor ; Jichun Zhang, Autor Fecha de publicación: 2021 Artículo en la página: pp. 2449-2458 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Factor neurotrófico derivado del cerebro, Hipocampo, Corteza infralímbica, Núcleo accumbens, Corteza preliminar, proBDNF Resumen: Role of brain-derived neurotrophic factor (BDNF)-TrkB signaling in a learned helplessness (LH) model of depression was investigated. LH rats showed a reduction of BDNF in the medial prefrontal cortex (mPFC), CA3, and dentate gyrus (DG) of the hippocampus, whereas LH rats showed an increase in BDNF in the nucleus accumbens (NAc). Furthermore,... Link: ./index.php?lvl=notice_display&id=26671 [artículo] Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist [texto impreso] / Yukihikko Shirayama, Autor ; Chun Yang, Autor ; Jichun Zhang, Autor . - 2021 . - pp. 2449-2458. Idioma : Inglés (eng) Idioma original : Inglés (eng) in European Neuropsychopharmacology > Año 2015 - Vol. 25 - No.12 (Diciembre) . - pp. 2449-2458 Palabras clave: Factor neurotrófico derivado del cerebro, Hipocampo, Corteza infralímbica, Núcleo accumbens, Corteza preliminar, proBDNF Resumen: Role of brain-derived neurotrophic factor (BDNF)-TrkB signaling in a learned helplessness (LH) model of depression was investigated. LH rats showed a reduction of BDNF in the medial prefrontal cortex (mPFC), CA3, and dentate gyrus (DG) of the hippocampus, whereas LH rats showed an increase in BDNF in the nucleus accumbens (NAc). Furthermore,... Link: ./index.php?lvl=notice_display&id=26671

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