Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists / Cheryse A. Furman en European Neuropsychopharmacology, Año 2015 - Vol. 25 - No.9 (Septiembre)

Público ISBD [artículo]  inEuropean Neuropsychopharmacology > Año 2015 - Vol. 25 - No.9 (Septiembre) . - pp. 1448-1461 Título : Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists Tipo de documento: texto impreso Autores: Cheryse A. Furman, Autor ; Rebecca A. Roof, Autor ; Amy E. Moritz, Autor Fecha de publicación: 2021 Artículo en la página: pp. 1448-1461 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Receptor de dopamina, Receptor D3, Bivalente, Bitopic, Alostérico, Antagonistas de la dopamina Resumen: The D3 dopamine receptor represents an important target in drug addiction in that reducing receptor activity may attenuate the self-administration of drugs and/or disrupt drug or cue-induced relapse. Medicinal chemistry efforts have led to the development of D3 preferring antagonists and partial agonists that are >100-fold selective vs. Link: ./index.php?lvl=notice_display&id=26742 [artículo] Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists [texto impreso] / Cheryse A. Furman, Autor ; Rebecca A. Roof, Autor ; Amy E. Moritz, Autor . - 2021 . - pp. 1448-1461. Idioma : Inglés (eng) Idioma original : Inglés (eng) in European Neuropsychopharmacology > Año 2015 - Vol. 25 - No.9 (Septiembre) . - pp. 1448-1461 Palabras clave: Receptor de dopamina, Receptor D3, Bivalente, Bitopic, Alostérico, Antagonistas de la dopamina Resumen: The D3 dopamine receptor represents an important target in drug addiction in that reducing receptor activity may attenuate the self-administration of drugs and/or disrupt drug or cue-induced relapse. Medicinal chemistry efforts have led to the development of D3 preferring antagonists and partial agonists that are >100-fold selective vs. Link: ./index.php?lvl=notice_display&id=26742

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