Effect sizes of deletions and duplications on autism risk across the genome / Elise Douard en The American Journal of Psychiatry, Año 2021 - Vol. 178 - No.1 (Enero)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 87-98 Título : Effect sizes of deletions and duplications on autism risk across the genome Tipo de documento: texto impreso Autores: Elise Douard, Autor ; Abderrahim Zeribi, Autor ; Catherine Schramm, Autor Fecha de publicación: 2021 Artículo en la página: pp. 87-98 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno del espectro autista, Copiar variantes de números, IQ Resumen: Deleterious copy number variants (CNVs) are identified in up to 20% of individuals with autism. However, levels of autism risk conferred by most rare CNVs remain unknown. The authors recently developed statistical models to estimate the effect size on IQ of all CNVs, including undocumented ones. In this study, the authors extended this model to autism susceptibility. Link: ./index.php?lvl=notice_display&id=26866 [artículo] Effect sizes of deletions and duplications on autism risk across the genome [texto impreso] / Elise Douard, Autor ; Abderrahim Zeribi, Autor ; Catherine Schramm, Autor . - 2021 . - pp. 87-98. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2021 - Vol. 178 - No.1 (Enero) . - pp. 87-98 Palabras clave: Trastorno del espectro autista, Copiar variantes de números, IQ Resumen: Deleterious copy number variants (CNVs) are identified in up to 20% of individuals with autism. However, levels of autism risk conferred by most rare CNVs remain unknown. The authors recently developed statistical models to estimate the effect size on IQ of all CNVs, including undocumented ones. In this study, the authors extended this model to autism susceptibility. Link: ./index.php?lvl=notice_display&id=26866

Similar rates of deleterious copy number variants in early-onset psychosis and autism spectrum disorder / Catherine A. Brownstein en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 11 (Noviembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 853-861 Título : Similar rates of deleterious copy number variants in early-onset psychosis and autism spectrum disorder Tipo de documento: texto impreso Autores: Catherine A. Brownstein, Autor ; Elise Douard, Autor ; Josephine Mollon, Autor Fecha de publicación: 2023 Artículo en la página: pp. 853-861 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Psicosis, espectro esquizofrénico y otros trastornos psicóticos, Psiquiatría infantil y del adolescente, Genética - Genómica Resumen: Copy number variants (CNVs) are strongly associated with neurodevelopmental and psychotic disorders. Early-onset psychosis (EOP), where symptoms appear before 18 years of age, is thought to be more strongly influenced by genetic factors than adult-onset psychotic disorders. However, the prevalence and effect of CNVs in EOP is unclear. Link: ./index.php?lvl=notice_display&id=29769 [artículo] Similar rates of deleterious copy number variants in early-onset psychosis and autism spectrum disorder [texto impreso] / Catherine A. Brownstein, Autor ; Elise Douard, Autor ; Josephine Mollon, Autor . - 2023 . - pp. 853-861. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 853-861 Palabras clave: Psicosis, espectro esquizofrénico y otros trastornos psicóticos, Psiquiatría infantil y del adolescente, Genética - Genómica Resumen: Copy number variants (CNVs) are strongly associated with neurodevelopmental and psychotic disorders. Early-onset psychosis (EOP), where symptoms appear before 18 years of age, is thought to be more strongly influenced by genetic factors than adult-onset psychotic disorders. However, the prevalence and effect of CNVs in EOP is unclear. Link: ./index.php?lvl=notice_display&id=29769

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