Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine induced agranulocytosis / Maria C. Athanasiou en The Journal of Clinical Psychiatry, Año 2011 - Vol.72 - No. 4 (Abril)

Público ISBD [artículo]  inThe Journal of Clinical Psychiatry > Año 2011 - Vol.72 - No. 4 (Abril) . - pp. 458-463 Título : Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine induced agranulocytosis Tipo de documento: texto impreso Autores: Maria C. Athanasiou, Autor ; Michael Dettling, Autor ; Ingolf Cascorbi, Autor Fecha de publicación: 2022 Artículo en la página: pp. 458-463 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Agranulocitosis, Antipsicóticos, Clozapina, Predisposición genética a la enfermedad, Antígenos HLA-DQ, Polimorfismo. Resumen: Clozapine is considered to be the most efficacious drug to treat schizophrenia, although it is underutilized, partially due to a side effect of agranulocytosis. This analysis of 74 candidate genes was designed to identify an association between sequence variants and clozapine-induced agranulocytosis (CIA). Link: ./index.php?lvl=notice_display&id=27970 [artículo] Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine induced agranulocytosis [texto impreso] / Maria C. Athanasiou, Autor ; Michael Dettling, Autor ; Ingolf Cascorbi, Autor . - 2022 . - pp. 458-463. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The Journal of Clinical Psychiatry > Año 2011 - Vol.72 - No. 4 (Abril) . - pp. 458-463 Palabras clave: Agranulocitosis, Antipsicóticos, Clozapina, Predisposición genética a la enfermedad, Antígenos HLA-DQ, Polimorfismo. Resumen: Clozapine is considered to be the most efficacious drug to treat schizophrenia, although it is underutilized, partially due to a side effect of agranulocytosis. This analysis of 74 candidate genes was designed to identify an association between sequence variants and clozapine-induced agranulocytosis (CIA). Link: ./index.php?lvl=notice_display&id=27970

Impact of myeloperoxidase and nadph-oxidase polymorphisms in drug-induced agranulocytosis / Igor Mosyagin en Journal of Clinical Psychopharmacology, Año 2004 - Vol. 24 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 6 (Diciembre) . - pp. 613-617 Título : Impact of myeloperoxidase and nadph-oxidase polymorphisms in drug-induced agranulocytosis Tipo de documento: texto impreso Autores: Igor Mosyagin, Autor ; Michael Dettling, Autor ; Ivar Roots, Autor Fecha de publicación: 2023 Artículo en la página: pp. 613-617 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Agranulocitosis, Agentes antipsicóticos, Peroxidasa, Esquizofrenia. Resumen: Therapy of the atypical antipsychotic drug clozapine is limited by a comparatively high incidence of agranulocytosis in 0.8% of patients. This severe side effect is possibly based on the clozapine-mediated stimulation of cytokines and soluble cytokine receptors release, followed by induction of granulocyte proliferation and induction of myeloperoxidase (MPO) and NADPH-oxidase. Link: ./index.php?lvl=notice_display&id=30933 [artículo] Impact of myeloperoxidase and nadph-oxidase polymorphisms in drug-induced agranulocytosis [texto impreso] / Igor Mosyagin, Autor ; Michael Dettling, Autor ; Ivar Roots, Autor . - 2023 . - pp. 613-617. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 6 (Diciembre) . - pp. 613-617 Palabras clave: Agranulocitosis, Agentes antipsicóticos, Peroxidasa, Esquizofrenia. Resumen: Therapy of the atypical antipsychotic drug clozapine is limited by a comparatively high incidence of agranulocytosis in 0.8% of patients. This severe side effect is possibly based on the clozapine-mediated stimulation of cytokines and soluble cytokine receptors release, followed by induction of granulocyte proliferation and induction of myeloperoxidase (MPO) and NADPH-oxidase. Link: ./index.php?lvl=notice_display&id=30933

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