Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation / Guy Hindley en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 11 (Noviembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 833-843 Título : Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation Tipo de documento: texto impreso Autores: Guy Hindley, Autor ; Oleksandr Frei, Autor ; Alexey A. Shadrin, Autor Fecha de publicación: 2023 Artículo en la página: pp. 833-843 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Genética - Genómica, Trastornos bipolares y relacionados, Trastornos depresivos, Trastornos del neurodesarrollo, Trastorno por déficit de atención con hiperactividad (TDAH), Espectro de esquizofrenia y otros trastornos psicóticos Resumen: Mental disorders are heritable and polygenic, and genome-wide genetic correlations (rg) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, rg may underestimate the shared genetic underpinnings of mental disorders and related traits because it does not differentiate mixtures of concordant and discordant genetic effects from an absence of genetic overlap. Link: ./index.php?lvl=notice_display&id=29767 [artículo] Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation [texto impreso] / Guy Hindley, Autor ; Oleksandr Frei, Autor ; Alexey A. Shadrin, Autor . - 2023 . - pp. 833-843. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 833-843 Palabras clave: Genética - Genómica, Trastornos bipolares y relacionados, Trastornos depresivos, Trastornos del neurodesarrollo, Trastorno por déficit de atención con hiperactividad (TDAH), Espectro de esquizofrenia y otros trastornos psicóticos Resumen: Mental disorders are heritable and polygenic, and genome-wide genetic correlations (rg) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, rg may underestimate the shared genetic underpinnings of mental disorders and related traits because it does not differentiate mixtures of concordant and discordant genetic effects from an absence of genetic overlap. Link: ./index.php?lvl=notice_display&id=29767

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