Striatal and extrastriatal d2/d3-receptor-binding properties of ziprasidone / Ingo B. Vernaleken en Journal of Clinical Psychopharmacology, Año 2008 - Vol. 28 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2008 - Vol. 28 - No. 6 (Diciembre) . - pp. 608-617 Título : Striatal and extrastriatal d2/d3-receptor-binding properties of ziprasidone : A positron emission tomography study with [18F]fallypride and [11C]raclopride (D2/D3-receptor occupancy of ziprasidone) Tipo de documento: texto impreso Autores: Ingo B. Vernaleken, Autor ; Christine Fellows, Autor ; Hildegard Janouschek, Autor Fecha de publicación: 2023 Artículo en la página: pp. 608-617 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Agentes antipsicóticos, Relación Dosis-Respuesta, Piperazinas, Radiofármacos, Receptores de Dopamina D2, Esquizofrenia. Resumen: To elucidate the "atypicality" of ziprasidone, its striatal and extrastriatal D2/D3-receptor binding was characterized in patients with schizophrenia under steady-state conditions. These data were compared with striatal receptor occupancy values after single-dose ziprasidone ingestion in healthy controls. [18F]fallypride positron emission tomography (PET) recordings were obtained in 15 patients under steady-state ziprasidone treatment at varying time points after the last dose. Link: ./index.php?lvl=notice_display&id=30818 [artículo] Striatal and extrastriatal d2/d3-receptor-binding properties of ziprasidone : A positron emission tomography study with [18F]fallypride and [11C]raclopride (D2/D3-receptor occupancy of ziprasidone) [texto impreso] / Ingo B. Vernaleken, Autor ; Christine Fellows, Autor ; Hildegard Janouschek, Autor . - 2023 . - pp. 608-617. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2008 - Vol. 28 - No. 6 (Diciembre) . - pp. 608-617 Palabras clave: Agentes antipsicóticos, Relación Dosis-Respuesta, Piperazinas, Radiofármacos, Receptores de Dopamina D2, Esquizofrenia. Resumen: To elucidate the "atypicality" of ziprasidone, its striatal and extrastriatal D2/D3-receptor binding was characterized in patients with schizophrenia under steady-state conditions. These data were compared with striatal receptor occupancy values after single-dose ziprasidone ingestion in healthy controls. [18F]fallypride positron emission tomography (PET) recordings were obtained in 15 patients under steady-state ziprasidone treatment at varying time points after the last dose. Link: ./index.php?lvl=notice_display&id=30818

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