Extension of a pilot study: impact from the cytochrome p450 2d6 polymorphism on outcome and costs associated with severe mental illness / Wen Hwei Chou en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 246-251 Título : Extension of a pilot study: impact from the cytochrome p450 2d6 polymorphism on outcome and costs associated with severe mental illness Tipo de documento: texto impreso Autores: Wen Hwei Chou, Autor ; Feng Xiang Yan, Autor ; Jose de Leon, Autor Fecha de publicación: 2023 Artículo en la página: pp. 246-251 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Citocromo P-450 CYP2D6, Duración de la estancia, Examen neurológico, Trastornos psicóticos. Resumen: The influence of cytochrome P450 2D6 (CYP2D6) genetic variability was examined in psychiatric inpatients by evaluating adverse drug events (ADEs), hospital stays, and total costs over a 1-year period in an extension of a previously published brief report. One hundred consecutive psychiatric patients from Eastern State Hospital in Lexington, Kentucky, were genotyped for CYP2D6 expression. Link: ./index.php?lvl=notice_display&id=31222 [artículo] Extension of a pilot study: impact from the cytochrome p450 2d6 polymorphism on outcome and costs associated with severe mental illness [texto impreso] / Wen Hwei Chou, Autor ; Feng Xiang Yan, Autor ; Jose de Leon, Autor . - 2023 . - pp. 246-251. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 246-251 Palabras clave: Antipsicóticos, Citocromo P-450 CYP2D6, Duración de la estancia, Examen neurológico, Trastornos psicóticos. Resumen: The influence of cytochrome P450 2D6 (CYP2D6) genetic variability was examined in psychiatric inpatients by evaluating adverse drug events (ADEs), hospital stays, and total costs over a 1-year period in an extension of a previously published brief report. One hundred consecutive psychiatric patients from Eastern State Hospital in Lexington, Kentucky, were genotyped for CYP2D6 expression. Link: ./index.php?lvl=notice_display&id=31222

Polymorphic variations in gstm1, gstt1, pgp, cyp2d6, cyp3a5, and dopamine d2 and d3 receptors and their association with tardive dyskinesia in severe mental illness / Jose de Leon en Journal of Clinical Psychopharmacology, Año 2005 - Vol. 25 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 448-456 Título : Polymorphic variations in gstm1, gstt1, pgp, cyp2d6, cyp3a5, and dopamine d2 and d3 receptors and their association with tardive dyskinesia in severe mental illness Tipo de documento: texto impreso Autores: Jose de Leon, Autor ; Margaret T. Susce, Autor ; Run Mei Pan, Autor Fecha de publicación: 2023 Artículo en la página: pp. 448-456 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Discinesia inducida por fármacos, Trastornos mentales, Farmacogenética, Trastornos psicóticos, Risperidona. Resumen: This study tested the association between tardive dyskinesia (TD) and polymorphic variations in (a) 2 cytochrome P450 (CYP) genes (CYP2D6 or CYP3A5), (b) 2 DRD2 variants (Ser311Cys and -141C Ins/del) and the Ser9Gly DRD3 variants, (c) 2 glutathione S-transferases (GSTT1 and GSTM1), and (d) variations in the PgP gene, MDR1. Link: ./index.php?lvl=notice_display&id=30890 [artículo] Polymorphic variations in gstm1, gstt1, pgp, cyp2d6, cyp3a5, and dopamine d2 and d3 receptors and their association with tardive dyskinesia in severe mental illness [texto impreso] / Jose de Leon, Autor ; Margaret T. Susce, Autor ; Run Mei Pan, Autor . - 2023 . - pp. 448-456. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2005 - Vol. 25 - No. 5 (Octubre) . - pp. 448-456 Palabras clave: Antipsicóticos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Discinesia inducida por fármacos, Trastornos mentales, Farmacogenética, Trastornos psicóticos, Risperidona. Resumen: This study tested the association between tardive dyskinesia (TD) and polymorphic variations in (a) 2 cytochrome P450 (CYP) genes (CYP2D6 or CYP3A5), (b) 2 DRD2 variants (Ser311Cys and -141C Ins/del) and the Ser9Gly DRD3 variants, (c) 2 glutathione S-transferases (GSTT1 and GSTM1), and (d) variations in the PgP gene, MDR1. Link: ./index.php?lvl=notice_display&id=30890

Serum antimuscarinic activity during clozapine treatment / Jose de Leon en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 4 (Agosto) . - pp. 336-341 Título : Serum antimuscarinic activity during clozapine treatment Tipo de documento: texto impreso Autores: Jose de Leon, Autor ; Aruby Odom White, Autor ; Richard C. Josiassen, Autor Fecha de publicación: 2023 Artículo en la página: pp. 336-341 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Clozapina, Antagonistas muscarínicos, Esquizofrenia. Resumen: This study attempts: (1) to verify that serum antimuscarinic activity is related to clozapine dose, and more importantly to clozapine plasma concentrations; (2) to explore whether norclozapine has serum antimuscarinic activity; (3) to explore whether antimuscarinic activity is related to clozapine side effects; and (4) to compare the serum antimuscarinic activities of clozapine with those of antiparkinsonian drugs and other antipsychotics. Link: ./index.php?lvl=notice_display&id=31007 [artículo] Serum antimuscarinic activity during clozapine treatment [texto impreso] / Jose de Leon, Autor ; Aruby Odom White, Autor ; Richard C. Josiassen, Autor . - 2023 . - pp. 336-341. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 4 (Agosto) . - pp. 336-341 Palabras clave: Clozapina, Antagonistas muscarínicos, Esquizofrenia. Resumen: This study attempts: (1) to verify that serum antimuscarinic activity is related to clozapine dose, and more importantly to clozapine plasma concentrations; (2) to explore whether norclozapine has serum antimuscarinic activity; (3) to explore whether antimuscarinic activity is related to clozapine side effects; and (4) to compare the serum antimuscarinic activities of clozapine with those of antiparkinsonian drugs and other antipsychotics. Link: ./index.php?lvl=notice_display&id=31007

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