Impact of myeloperoxidase and nadph-oxidase polymorphisms in drug-induced agranulocytosis / Igor Mosyagin en Journal of Clinical Psychopharmacology, Año 2004 - Vol. 24 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 6 (Diciembre) . - pp. 613-617 Título : Impact of myeloperoxidase and nadph-oxidase polymorphisms in drug-induced agranulocytosis Tipo de documento: texto impreso Autores: Igor Mosyagin, Autor ; Michael Dettling, Autor ; Ivar Roots, Autor Fecha de publicación: 2023 Artículo en la página: pp. 613-617 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Agranulocitosis, Agentes antipsicóticos, Peroxidasa, Esquizofrenia. Resumen: Therapy of the atypical antipsychotic drug clozapine is limited by a comparatively high incidence of agranulocytosis in 0.8% of patients. This severe side effect is possibly based on the clozapine-mediated stimulation of cytokines and soluble cytokine receptors release, followed by induction of granulocyte proliferation and induction of myeloperoxidase (MPO) and NADPH-oxidase. Link: ./index.php?lvl=notice_display&id=30933 [artículo] Impact of myeloperoxidase and nadph-oxidase polymorphisms in drug-induced agranulocytosis [texto impreso] / Igor Mosyagin, Autor ; Michael Dettling, Autor ; Ivar Roots, Autor . - 2023 . - pp. 613-617. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 6 (Diciembre) . - pp. 613-617 Palabras clave: Agranulocitosis, Agentes antipsicóticos, Peroxidasa, Esquizofrenia. Resumen: Therapy of the atypical antipsychotic drug clozapine is limited by a comparatively high incidence of agranulocytosis in 0.8% of patients. This severe side effect is possibly based on the clozapine-mediated stimulation of cytokines and soluble cytokine receptors release, followed by induction of granulocyte proliferation and induction of myeloperoxidase (MPO) and NADPH-oxidase. Link: ./index.php?lvl=notice_display&id=30933

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