Dose-related pharmacokinetics and pharmacodynamics of valproate in the elderly / Susy Felix en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 5 (Octubre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 471-478 Título : Dose-related pharmacokinetics and pharmacodynamics of valproate in the elderly Tipo de documento: texto impreso Autores: Susy Felix, Autor ; Beth A. Sproule, Autor ; Brian G. Hardy, Autor Fecha de publicación: 2023 Artículo en la página: pp. 471-478 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Tasa de aclaramiento metabólico, Ácido Valproico. Resumen: Valproate exhibits a complex pharmacokinetic profile due to concentration-dependent protein binding and clearance. It has been shown that the protein binding of valproate decreases as the serum concentration increases in a young adult population. Furthermore, the percentage of protein binding is lower in the elderly compared with young adults at comparable low therapeutic serum concentrations. Link: ./index.php?lvl=notice_display&id=31001 [artículo] Dose-related pharmacokinetics and pharmacodynamics of valproate in the elderly [texto impreso] / Susy Felix, Autor ; Beth A. Sproule, Autor ; Brian G. Hardy, Autor . - 2023 . - pp. 471-478. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 471-478 Palabras clave: Tasa de aclaramiento metabólico, Ácido Valproico. Resumen: Valproate exhibits a complex pharmacokinetic profile due to concentration-dependent protein binding and clearance. It has been shown that the protein binding of valproate decreases as the serum concentration increases in a young adult population. Furthermore, the percentage of protein binding is lower in the elderly compared with young adults at comparable low therapeutic serum concentrations. Link: ./index.php?lvl=notice_display&id=31001

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