The role of cytochrome p450 2c19 activity in flunitrazepam metabolism in vivo / Inbal Gafni M. en Journal of Clinical Psychopharmacology, Año 2003 - Vol. 23 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 2 (Abril) . - pp. 169-175 Título : The role of cytochrome p450 2c19 activity in flunitrazepam metabolism in vivo Tipo de documento: texto impreso Autores: Inbal Gafni M., Autor ; Usoa E. Busto, Autor ; Rachel F. Tyndale, Autor Fecha de publicación: 2023 Artículo en la página: pp. 169-175 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Ansiolíticos, Cromatografía líquida, Citocromo P-450 CYP2C19, Flunitrazepam. Resumen: Flunitrazepam, a hypnotic benzodiazepine, is widely prescribed around the world for the treatment of insomnia and as a preanesthetic. In vitro studies have shown that the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam is mediated in part by the polymorphic enzyme CYP2C19. The objective was to examine the role of CYP2C19 activity in determining flunitrazepam kinetics in vivo. Link: ./index.php?lvl=notice_display&id=31034 [artículo] The role of cytochrome p450 2c19 activity in flunitrazepam metabolism in vivo [texto impreso] / Inbal Gafni M., Autor ; Usoa E. Busto, Autor ; Rachel F. Tyndale, Autor . - 2023 . - pp. 169-175. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 2 (Abril) . - pp. 169-175 Palabras clave: Ansiolíticos, Cromatografía líquida, Citocromo P-450 CYP2C19, Flunitrazepam. Resumen: Flunitrazepam, a hypnotic benzodiazepine, is widely prescribed around the world for the treatment of insomnia and as a preanesthetic. In vitro studies have shown that the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam is mediated in part by the polymorphic enzyme CYP2C19. The objective was to examine the role of CYP2C19 activity in determining flunitrazepam kinetics in vivo. Link: ./index.php?lvl=notice_display&id=31034

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