Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline / Sachiyo Morita en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 141-149 Título : Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline Tipo de documento: texto impreso Autores: Sachiyo Morita, Autor ; Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor Fecha de publicación: 2023 Artículo en la página: pp. 141-149 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos de adaptación, Trastorno bipolar, Trastorno depresivo mayor, Etnia - genética, Nortriptilina. Resumen: The authors investigated the impact of the CYP2D6 genotype on steady-state concentrations of nortriptyline (NT) and its metabolites, trans-10-hydroxynortriptyline (EHNT) and cis-10-hydroxynortriptyline in a Japanese population of psychiatric patients. Forty-one patients (20 men and 21 women) were orally administered nortriptyline hydrochloride. Link: ./index.php?lvl=notice_display&id=31208 [artículo] Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline [texto impreso] / Sachiyo Morita, Autor ; Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor . - 2023 . - pp. 141-149. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 141-149 Palabras clave: Trastornos de adaptación, Trastorno bipolar, Trastorno depresivo mayor, Etnia - genética, Nortriptilina. Resumen: The authors investigated the impact of the CYP2D6 genotype on steady-state concentrations of nortriptyline (NT) and its metabolites, trans-10-hydroxynortriptyline (EHNT) and cis-10-hydroxynortriptyline in a Japanese population of psychiatric patients. Forty-one patients (20 men and 21 women) were orally administered nortriptyline hydrochloride. Link: ./index.php?lvl=notice_display&id=31208

The impact of cyp2c19 and cyp2d6 genotypes on metabolism of amitriptyline in japanese psychiatric patients / Kazutaka Shimoda en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 371-378 Título : The impact of cyp2c19 and cyp2d6 genotypes on metabolism of amitriptyline in japanese psychiatric patients Tipo de documento: texto impreso Autores: Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor ; Aya Yokono, Autor Fecha de publicación: 2023 Artículo en la página: pp. 371-378 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Amitriptilina, Agentes antidepresivos tricíclicos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Trastornos mentales, Oxigenasas de función mixta, Mutación. Resumen: We investigated the effect of the CYP2C19 and CYP2D6 genotypes on the metabolism of amitriptyline (AT) in Japanese psychiatric patients. Steady-state concentrations of AT and its metabolites (nortriptyline [NT], trans-10-hydroxy-nortriptyline [EHNT], cis-10-hydroxy-nortriptyline [ZHNT], trans-10-hydroxy-amitriptyline [EHAT], and cis-10-hydroxy-amitriptyline [ZHAT]) in 50 patients were determined by high-performance liquid chromatography. Link: ./index.php?lvl=notice_display&id=31053 [artículo] The impact of cyp2c19 and cyp2d6 genotypes on metabolism of amitriptyline in japanese psychiatric patients [texto impreso] / Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor ; Aya Yokono, Autor . - 2023 . - pp. 371-378. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 371-378 Palabras clave: Amitriptilina, Agentes antidepresivos tricíclicos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Trastornos mentales, Oxigenasas de función mixta, Mutación. Resumen: We investigated the effect of the CYP2C19 and CYP2D6 genotypes on the metabolism of amitriptyline (AT) in Japanese psychiatric patients. Steady-state concentrations of AT and its metabolites (nortriptyline [NT], trans-10-hydroxy-nortriptyline [EHNT], cis-10-hydroxy-nortriptyline [ZHNT], trans-10-hydroxy-amitriptyline [EHAT], and cis-10-hydroxy-amitriptyline [ZHAT]) in 50 patients were determined by high-performance liquid chromatography. Link: ./index.php?lvl=notice_display&id=31053

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