Interindividual variation in bromperidol metabolism and relationship to therapeutic effects / Toshiyuki Someya en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 175-180 Título : Interindividual variation in bromperidol metabolism and relationship to therapeutic effects Tipo de documento: texto impreso Autores: Toshiyuki Someya, Autor ; Tatsuyuki Muratake, Autor ; Genta Hirokane, Autor Fecha de publicación: 2023 Artículo en la página: pp. 175-180 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Biotransformación, Haloperidol, Esquizofrenia. Resumen: Plasma concentrations of bromperidol (BRP) and reduced bromperidol (RBRP) were determined in 31 patients with schizophrenia who were administered BRP for their psychiatric symptoms. Activities of carbonyl reductase in red blood cells were assayed using BRP as a substrate. Link: ./index.php?lvl=notice_display&id=31212 [artículo] Interindividual variation in bromperidol metabolism and relationship to therapeutic effects [texto impreso] / Toshiyuki Someya, Autor ; Tatsuyuki Muratake, Autor ; Genta Hirokane, Autor . - 2023 . - pp. 175-180. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 175-180 Palabras clave: Antipsicóticos, Biotransformación, Haloperidol, Esquizofrenia. Resumen: Plasma concentrations of bromperidol (BRP) and reduced bromperidol (RBRP) were determined in 31 patients with schizophrenia who were administered BRP for their psychiatric symptoms. Activities of carbonyl reductase in red blood cells were assayed using BRP as a substrate. Link: ./index.php?lvl=notice_display&id=31212

Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline / Sachiyo Morita en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 141-149 Título : Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline Tipo de documento: texto impreso Autores: Sachiyo Morita, Autor ; Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor Fecha de publicación: 2023 Artículo en la página: pp. 141-149 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastornos de adaptación, Trastorno bipolar, Trastorno depresivo mayor, Etnia - genética, Nortriptilina. Resumen: The authors investigated the impact of the CYP2D6 genotype on steady-state concentrations of nortriptyline (NT) and its metabolites, trans-10-hydroxynortriptyline (EHNT) and cis-10-hydroxynortriptyline in a Japanese population of psychiatric patients. Forty-one patients (20 men and 21 women) were orally administered nortriptyline hydrochloride. Link: ./index.php?lvl=notice_display&id=31208 [artículo] Steady state plasma levels of nortriptyline and its hydroxylated metabolites in japanese patients: impact of cyp2d6 genotype on the hydroxylation of nortriptyline [texto impreso] / Sachiyo Morita, Autor ; Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor . - 2023 . - pp. 141-149. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 2 (Abril) . - pp. 141-149 Palabras clave: Trastornos de adaptación, Trastorno bipolar, Trastorno depresivo mayor, Etnia - genética, Nortriptilina. Resumen: The authors investigated the impact of the CYP2D6 genotype on steady-state concentrations of nortriptyline (NT) and its metabolites, trans-10-hydroxynortriptyline (EHNT) and cis-10-hydroxynortriptyline in a Japanese population of psychiatric patients. Forty-one patients (20 men and 21 women) were orally administered nortriptyline hydrochloride. Link: ./index.php?lvl=notice_display&id=31208

The effect of cyp2c19 and cyp2d6 genotypes on the metabolism of clomipramine in japanese psychiatric patients / Aya Yokono en Journal of Clinical Psychopharmacology, Año 2001 - Vol. 21 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 549-555 Título : The effect of cyp2c19 and cyp2d6 genotypes on the metabolism of clomipramine in japanese psychiatric patients Tipo de documento: texto impreso Autores: Aya Yokono, Autor ; Sachiyo Morita, Autor ; Toshiyuki Someya, Autor Fecha de publicación: 2023 Artículo en la página: pp. 549-555 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos tricíclicos, Clomipramina, Citocromo P-450 CYP2C19, Sistema enzimático citocromo P-450, Trastorno Depresivo, Oxigenasas de función mixta, Mutación genética. Resumen: In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of cytochrome P450 (CYP) CYP2C19 and CYP2D6. Fifty-one Japanese patients (18 men and 33 women) were administered 10 to 250 mg/day of C by mouth and maintained on the same daily dose of C for at least 2 weeks to obtain steady-state concentrations. Link: ./index.php?lvl=notice_display&id=31099 [artículo] The effect of cyp2c19 and cyp2d6 genotypes on the metabolism of clomipramine in japanese psychiatric patients [texto impreso] / Aya Yokono, Autor ; Sachiyo Morita, Autor ; Toshiyuki Someya, Autor . - 2023 . - pp. 549-555. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 549-555 Palabras clave: Antidepresivos tricíclicos, Clomipramina, Citocromo P-450 CYP2C19, Sistema enzimático citocromo P-450, Trastorno Depresivo, Oxigenasas de función mixta, Mutación genética. Resumen: In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of cytochrome P450 (CYP) CYP2C19 and CYP2D6. Fifty-one Japanese patients (18 men and 33 women) were administered 10 to 250 mg/day of C by mouth and maintained on the same daily dose of C for at least 2 weeks to obtain steady-state concentrations. Link: ./index.php?lvl=notice_display&id=31099

The impact of cyp2c19 and cyp2d6 genotypes on metabolism of amitriptyline in japanese psychiatric patients / Kazutaka Shimoda en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 371-378 Título : The impact of cyp2c19 and cyp2d6 genotypes on metabolism of amitriptyline in japanese psychiatric patients Tipo de documento: texto impreso Autores: Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor ; Aya Yokono, Autor Fecha de publicación: 2023 Artículo en la página: pp. 371-378 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Amitriptilina, Agentes antidepresivos tricíclicos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Trastornos mentales, Oxigenasas de función mixta, Mutación. Resumen: We investigated the effect of the CYP2C19 and CYP2D6 genotypes on the metabolism of amitriptyline (AT) in Japanese psychiatric patients. Steady-state concentrations of AT and its metabolites (nortriptyline [NT], trans-10-hydroxy-nortriptyline [EHNT], cis-10-hydroxy-nortriptyline [ZHNT], trans-10-hydroxy-amitriptyline [EHAT], and cis-10-hydroxy-amitriptyline [ZHAT]) in 50 patients were determined by high-performance liquid chromatography. Link: ./index.php?lvl=notice_display&id=31053 [artículo] The impact of cyp2c19 and cyp2d6 genotypes on metabolism of amitriptyline in japanese psychiatric patients [texto impreso] / Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor ; Aya Yokono, Autor . - 2023 . - pp. 371-378. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 371-378 Palabras clave: Amitriptilina, Agentes antidepresivos tricíclicos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Trastornos mentales, Oxigenasas de función mixta, Mutación. Resumen: We investigated the effect of the CYP2C19 and CYP2D6 genotypes on the metabolism of amitriptyline (AT) in Japanese psychiatric patients. Steady-state concentrations of AT and its metabolites (nortriptyline [NT], trans-10-hydroxy-nortriptyline [EHNT], cis-10-hydroxy-nortriptyline [ZHNT], trans-10-hydroxy-amitriptyline [EHAT], and cis-10-hydroxy-amitriptyline [ZHAT]) in 50 patients were determined by high-performance liquid chromatography. Link: ./index.php?lvl=notice_display&id=31053

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