Biblioteca Humberto Rosselli Quijano
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[artículo]
| Título : |
The effect of cyp2c19 and cyp2d6 genotypes on the metabolism of clomipramine in japanese psychiatric patients |
| Tipo de documento: |
texto impreso |
| Autores: |
Aya Yokono, Autor ; Sachiyo Morita, Autor ; Toshiyuki Someya, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 549-555 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Antidepresivos tricíclicos, Clomipramina, Citocromo P-450 CYP2C19, Sistema enzimático citocromo P-450, Trastorno Depresivo, Oxigenasas de función mixta, Mutación genética. |
| Resumen: |
In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of cytochrome P450 (CYP) CYP2C19 and CYP2D6. Fifty-one Japanese patients (18 men and 33 women) were administered 10 to 250 mg/day of C by mouth and maintained on the same daily dose of C for at least 2 weeks to obtain steady-state concentrations. |
| Link: |
./index.php?lvl=notice_display&id=31099 |
in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 6 (Diciembre) . - pp. 549-555
|
[artículo]
| Título : |
The impact of cyp2c19 and cyp2d6 genotypes on metabolism of amitriptyline in japanese psychiatric patients |
| Tipo de documento: |
texto impreso |
| Autores: |
Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor ; Aya Yokono, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 371-378 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Amitriptilina, Agentes antidepresivos tricíclicos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Trastornos mentales, Oxigenasas de función mixta, Mutación. |
| Resumen: |
We investigated the effect of the CYP2C19 and CYP2D6 genotypes on the metabolism of amitriptyline (AT) in Japanese psychiatric patients. Steady-state concentrations of AT and its metabolites (nortriptyline [NT], trans-10-hydroxy-nortriptyline [EHNT], cis-10-hydroxy-nortriptyline [ZHNT], trans-10-hydroxy-amitriptyline [EHAT], and cis-10-hydroxy-amitriptyline [ZHAT]) in 50 patients were determined by high-performance liquid chromatography. |
| Link: |
./index.php?lvl=notice_display&id=31053 |
in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 371-378
[artículo] The impact of cyp2c19 and cyp2d6 genotypes on metabolism of amitriptyline in japanese psychiatric patients [texto impreso] / Kazutaka Shimoda, Autor ; Toshiyuki Someya, Autor ; Aya Yokono, Autor . - 2023 . - pp. 371-378. Idioma : Inglés ( eng) Idioma original : Inglés ( eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 4 (Agosto) . - pp. 371-378
| Palabras clave: |
Amitriptilina, Agentes antidepresivos tricíclicos, Citocromo P-450 CYP2D6, Sistema enzimático citocromo P-450, Trastornos mentales, Oxigenasas de función mixta, Mutación. |
| Resumen: |
We investigated the effect of the CYP2C19 and CYP2D6 genotypes on the metabolism of amitriptyline (AT) in Japanese psychiatric patients. Steady-state concentrations of AT and its metabolites (nortriptyline [NT], trans-10-hydroxy-nortriptyline [EHNT], cis-10-hydroxy-nortriptyline [ZHNT], trans-10-hydroxy-amitriptyline [EHAT], and cis-10-hydroxy-amitriptyline [ZHAT]) in 50 patients were determined by high-performance liquid chromatography. |
| Link: |
./index.php?lvl=notice_display&id=31053 |
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