Biblioteca Humberto Rosselli Quijano
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[artículo]
| Título : |
Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin |
| Tipo de documento: |
texto impreso |
| Autores: |
Sebastian Härtter, Autor ; Ximing Wang, Autor ; Harald Weigmann, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 167-174 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Citocromo P-450 CYP1A2, Fluvoxamina, Melatonina, Microsomas, Serotonina, Teofilina. |
| Resumen: |
Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal. rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes. |
| Link: |
./index.php?lvl=notice_display&id=31121 |
in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 2 (Abril) . - pp. 167-174
[artículo] Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin [texto impreso] / Sebastian Härtter, Autor ; Ximing Wang, Autor ; Harald Weigmann, Autor . - 2023 . - pp. 167-174. Idioma : Inglés ( eng) Idioma original : Inglés ( eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 2 (Abril) . - pp. 167-174
| Palabras clave: |
Citocromo P-450 CYP1A2, Fluvoxamina, Melatonina, Microsomas, Serotonina, Teofilina. |
| Resumen: |
Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal. rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes. |
| Link: |
./index.php?lvl=notice_display&id=31121 |
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