Diphenhydramine alters the disposition of venlafaxine through inhibition of cyp2d6 activity in humans / Étienne Lessard en Journal of Clinical Psychopharmacology, Año 2001 - Vol. 21 - No. 2 (Abril)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 2 (Abril) . - pp. 175-184 Título : Diphenhydramine alters the disposition of venlafaxine through inhibition of cyp2d6 activity in humans Tipo de documento: texto impreso Autores: Étienne Lessard, Autor ; Marie Andrée Yessine, Autor ; Bettina A. Hamelin, Autor Fecha de publicación: 2023 Artículo en la página: pp. 175-184 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antidepresivos, Ciclohexanoles, Citocromo P-450 CYP2D6, Difenhidramina, Interacción medicamentosa. Resumen: CYP2D6 is the major enzyme involved in the metabolism of venlafaxine. Subjects with a low CYP2D6 activity have increased plasma concentrations of venlafaxine that may predispose them to cardiovascular side effects. In vitro and in vivo studies showed that diphenhydramine, a nonprescription antihistamine, can inhibit CYP2D6 activity. Therefore, the authors investigated in this study a potential drug interaction between diphenhydramine and venlafaxine. Link: ./index.php?lvl=notice_display&id=31122 [artículo] Diphenhydramine alters the disposition of venlafaxine through inhibition of cyp2d6 activity in humans [texto impreso] / Étienne Lessard, Autor ; Marie Andrée Yessine, Autor ; Bettina A. Hamelin, Autor . - 2023 . - pp. 175-184. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 2 (Abril) . - pp. 175-184 Palabras clave: Antidepresivos, Ciclohexanoles, Citocromo P-450 CYP2D6, Difenhidramina, Interacción medicamentosa. Resumen: CYP2D6 is the major enzyme involved in the metabolism of venlafaxine. Subjects with a low CYP2D6 activity have increased plasma concentrations of venlafaxine that may predispose them to cardiovascular side effects. In vitro and in vivo studies showed that diphenhydramine, a nonprescription antihistamine, can inhibit CYP2D6 activity. Therefore, the authors investigated in this study a potential drug interaction between diphenhydramine and venlafaxine. Link: ./index.php?lvl=notice_display&id=31122

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