Epidemiologic investigation of the relative clearance of haloperidol by mixed-effect modeling using routine clinical pharmacokinetic data in japanese patients / Eiji Yukawa en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 6 (Diciembre)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 6 (Diciembre) . - pp. 685-690 Título : Epidemiologic investigation of the relative clearance of haloperidol by mixed-effect modeling using routine clinical pharmacokinetic data in japanese patients Tipo de documento: texto impreso Autores: Eiji Yukawa, Autor ; Tsuyoshi Hokazono, Autor ; Akiko Funakoshi, Autor Fecha de publicación: 2023 Artículo en la página: pp. 685-690 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Antipsicóticos, Haloperidol, Japón, Modelos biológicos, Esquizofrenia. Resumen: The steady-state trough concentrations of haloperidol were studied to clarify the role of the characteristics of Japanese patients in estimating haloperidol dosing regimens by using routine therapeutic drug-monitoring data. Nonlinear mixed-effects modeling (NONMEM) was used to estimate the effect of a variety of developmental and demographic factors on haloperidol clearance values using 270 serum level measurements obtained from 191 patients during their clinical course. Link: ./index.php?lvl=notice_display&id=31161 [artículo] Epidemiologic investigation of the relative clearance of haloperidol by mixed-effect modeling using routine clinical pharmacokinetic data in japanese patients [texto impreso] / Eiji Yukawa, Autor ; Tsuyoshi Hokazono, Autor ; Akiko Funakoshi, Autor . - 2023 . - pp. 685-690. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 6 (Diciembre) . - pp. 685-690 Palabras clave: Antipsicóticos, Haloperidol, Japón, Modelos biológicos, Esquizofrenia. Resumen: The steady-state trough concentrations of haloperidol were studied to clarify the role of the characteristics of Japanese patients in estimating haloperidol dosing regimens by using routine therapeutic drug-monitoring data. Nonlinear mixed-effects modeling (NONMEM) was used to estimate the effect of a variety of developmental and demographic factors on haloperidol clearance values using 270 serum level measurements obtained from 191 patients during their clinical course. Link: ./index.php?lvl=notice_display&id=31161

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