Intravenous versus oral administration of amitriptyline in patients with major depression / Eberhard A. Deisenhammer en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 417-422 Título : Intravenous versus oral administration of amitriptyline in patients with major depression Tipo de documento: texto impreso Autores: Eberhard A. Deisenhammer, Autor ; Alexandra B. Whitworth, Autor ; Christian Geretsegger, Autor Fecha de publicación: 2023 Artículo en la página: pp. 417-422 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Amitriptilina, Antidepresivos tricíclicos, Trastorno depresivo, Interacciones con la drogas. Resumen: Antidepressants can be administered by different routes. Advantages for either the oral or the intravenous administration have been suggested from pharmacokinetic as well as from clinical points of view. Controlled comparison studies of the two routes do not provide unequivocal recommendations. In this investigation, amitriptyline was studied over a 4-week period consisting of a 2-week, double-blind/double-dummy phase with either oral (150 mg/day), high-dose intravenous (150 mg/day), or medium-dose intravenous (100 mg/day) treatment and a 2-week phase of open oral treatment in 80 patients with major depression. Link: ./index.php?lvl=notice_display&id=31177 [artículo] Intravenous versus oral administration of amitriptyline in patients with major depression [texto impreso] / Eberhard A. Deisenhammer, Autor ; Alexandra B. Whitworth, Autor ; Christian Geretsegger, Autor . - 2023 . - pp. 417-422. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 417-422 Palabras clave: Amitriptilina, Antidepresivos tricíclicos, Trastorno depresivo, Interacciones con la drogas. Resumen: Antidepressants can be administered by different routes. Advantages for either the oral or the intravenous administration have been suggested from pharmacokinetic as well as from clinical points of view. Controlled comparison studies of the two routes do not provide unequivocal recommendations. In this investigation, amitriptyline was studied over a 4-week period consisting of a 2-week, double-blind/double-dummy phase with either oral (150 mg/day), high-dose intravenous (150 mg/day), or medium-dose intravenous (100 mg/day) treatment and a 2-week phase of open oral treatment in 80 patients with major depression. Link: ./index.php?lvl=notice_display&id=31177

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