[artículo]
| Título : |
Inhibition of cytochrome p450 2d6 modifies codeine abuse liability |
| Tipo de documento: |
texto impreso |
| Autores: |
Kalyani Kathiramalainathan, Autor ; Howard L. Kaplan, Autor ; Myroslava K. Romach, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 435-444 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Codeína, Inhibidores del citocromo P-450 CYP2D6, Inhibidores enzimáticos, Narcóticos, Trastornos relacionados con los opioides, Efectos de la pupila, Quinidina. |
| Resumen: |
Oral codeine preparations, widely used for analgesia and cough suppression, are abused by some individuals for their mood-altering properties. The enzymatic O-demethylation of codeine is catalyzed by cytochrome P450 2D6 (CYP2D6), leading to the production of metabolites (morphine, morphine-6-glucuronide) that are pharmacologically more potent than codeine. A placebo-controlled, single-blind study was conducted to characterize the subjective effects of codeine associated with abuse liability and to determine the importance of metabolic O-demethylation to codeine abuse liability. |
| Link: |
./index.php?lvl=notice_display&id=31180 |
in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 435-444
[artículo] Inhibition of cytochrome p450 2d6 modifies codeine abuse liability [texto impreso] / Kalyani Kathiramalainathan, Autor ; Howard L. Kaplan, Autor ; Myroslava K. Romach, Autor . - 2023 . - pp. 435-444. Idioma : Inglés ( eng) Idioma original : Inglés ( eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 435-444
| Palabras clave: |
Codeína, Inhibidores del citocromo P-450 CYP2D6, Inhibidores enzimáticos, Narcóticos, Trastornos relacionados con los opioides, Efectos de la pupila, Quinidina. |
| Resumen: |
Oral codeine preparations, widely used for analgesia and cough suppression, are abused by some individuals for their mood-altering properties. The enzymatic O-demethylation of codeine is catalyzed by cytochrome P450 2D6 (CYP2D6), leading to the production of metabolites (morphine, morphine-6-glucuronide) that are pharmacologically more potent than codeine. A placebo-controlled, single-blind study was conducted to characterize the subjective effects of codeine associated with abuse liability and to determine the importance of metabolic O-demethylation to codeine abuse liability. |
| Link: |
./index.php?lvl=notice_display&id=31180 |
|
Refinar búsquedaInhibition of cytochrome p450 2d6 modifies codeine abuse liability en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)
