Cytochrome p450 2d6 and treatment of codeine dependence / Myroslava K. Romach en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 43-45 Título : Cytochrome p450 2d6 and treatment of codeine dependence Tipo de documento: texto impreso Autores: Myroslava K. Romach, Autor ; S. Victoria Otton, Autor ; Gail Somer, Autor Fecha de publicación: 2023 Artículo en la página: pp. 43-45 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Analgésicos, Opioides, Codeína, Citocromo P-450 CYP2D6, Fluoxetina, Trastornos relacionados con opioides. Resumen: Oral opioid analgesics such as codeine are used extensively worldwide and are frequently misused. Codeine is a substrate of CYP2D6, a genetically polymorphic P450 enzyme, and is metabolized to the more potent drug morphine. CYP2D6 activity can be inhibited by fluoxetine, and the inhibition of morphine formation may help individuals reduce their use of codeine. Link: ./index.php?lvl=notice_display&id=31230 [artículo] Cytochrome p450 2d6 and treatment of codeine dependence [texto impreso] / Myroslava K. Romach, Autor ; S. Victoria Otton, Autor ; Gail Somer, Autor . - 2023 . - pp. 43-45. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 43-45 Palabras clave: Analgésicos, Opioides, Codeína, Citocromo P-450 CYP2D6, Fluoxetina, Trastornos relacionados con opioides. Resumen: Oral opioid analgesics such as codeine are used extensively worldwide and are frequently misused. Codeine is a substrate of CYP2D6, a genetically polymorphic P450 enzyme, and is metabolized to the more potent drug morphine. CYP2D6 activity can be inhibited by fluoxetine, and the inhibition of morphine formation may help individuals reduce their use of codeine. Link: ./index.php?lvl=notice_display&id=31230

Inhibition of cytochrome p450 2d6 modifies codeine abuse liability / Kalyani Kathiramalainathan en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 4 (Agosto)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 435-444 Título : Inhibition of cytochrome p450 2d6 modifies codeine abuse liability Tipo de documento: texto impreso Autores: Kalyani Kathiramalainathan, Autor ; Howard L. Kaplan, Autor ; Myroslava K. Romach, Autor Fecha de publicación: 2023 Artículo en la página: pp. 435-444 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Codeína, Inhibidores del citocromo P-450 CYP2D6, Inhibidores enzimáticos, Narcóticos, Trastornos relacionados con los opioides, Efectos de la pupila, Quinidina. Resumen: Oral codeine preparations, widely used for analgesia and cough suppression, are abused by some individuals for their mood-altering properties. The enzymatic O-demethylation of codeine is catalyzed by cytochrome P450 2D6 (CYP2D6), leading to the production of metabolites (morphine, morphine-6-glucuronide) that are pharmacologically more potent than codeine. A placebo-controlled, single-blind study was conducted to characterize the subjective effects of codeine associated with abuse liability and to determine the importance of metabolic O-demethylation to codeine abuse liability. Link: ./index.php?lvl=notice_display&id=31180 [artículo] Inhibition of cytochrome p450 2d6 modifies codeine abuse liability [texto impreso] / Kalyani Kathiramalainathan, Autor ; Howard L. Kaplan, Autor ; Myroslava K. Romach, Autor . - 2023 . - pp. 435-444. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 4 (Agosto) . - pp. 435-444 Palabras clave: Codeína, Inhibidores del citocromo P-450 CYP2D6, Inhibidores enzimáticos, Narcóticos, Trastornos relacionados con los opioides, Efectos de la pupila, Quinidina. Resumen: Oral codeine preparations, widely used for analgesia and cough suppression, are abused by some individuals for their mood-altering properties. The enzymatic O-demethylation of codeine is catalyzed by cytochrome P450 2D6 (CYP2D6), leading to the production of metabolites (morphine, morphine-6-glucuronide) that are pharmacologically more potent than codeine. A placebo-controlled, single-blind study was conducted to characterize the subjective effects of codeine associated with abuse liability and to determine the importance of metabolic O-demethylation to codeine abuse liability. Link: ./index.php?lvl=notice_display&id=31180

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