Single-dose pharmacokinetics of methylphenidate in cyp2d6 extensive and poor metabolizers / C. Lindsay DeVane en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 3 (Junio)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 3 (Junio) . - pp. 347-349 Título : Single-dose pharmacokinetics of methylphenidate in cyp2d6 extensive and poor metabolizers Tipo de documento: texto impreso Autores: C. Lindsay DeVane, Autor ; John S. Markowitz, Autor ; Stanley W. Carson, Autor Fecha de publicación: 2023 Artículo en la página: pp. 347-349 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Estimulantes del sistema nervioso central, Citocromo P-450 CYP2D6, Espectrometría de masas, Metilfenidato. Resumen: Six adults phenotyped as either extensive (N = 4) or poor (N = 2) metabolizers for cytochrome P450 (CYP) 2D6 were given a 10-mg oral dose of methylphenidate (MPH) on two separate occasions with and without quinidine, a potent CYP2D6 inhibitor. Quinidine had no significant effect on the pharmacokinetics of either MPH or ritalinic acid, its major metabolite, in either group of CYP2D6 metabolizers. Link: ./index.php?lvl=notice_display&id=31202 [artículo] Single-dose pharmacokinetics of methylphenidate in cyp2d6 extensive and poor metabolizers [texto impreso] / C. Lindsay DeVane, Autor ; John S. Markowitz, Autor ; Stanley W. Carson, Autor . - 2023 . - pp. 347-349. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 3 (Junio) . - pp. 347-349 Palabras clave: Estimulantes del sistema nervioso central, Citocromo P-450 CYP2D6, Espectrometría de masas, Metilfenidato. Resumen: Six adults phenotyped as either extensive (N = 4) or poor (N = 2) metabolizers for cytochrome P450 (CYP) 2D6 were given a 10-mg oral dose of methylphenidate (MPH) on two separate occasions with and without quinidine, a potent CYP2D6 inhibitor. Quinidine had no significant effect on the pharmacokinetics of either MPH or ritalinic acid, its major metabolite, in either group of CYP2D6 metabolizers. Link: ./index.php?lvl=notice_display&id=31202

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