Cytochrome p450 2d6 and treatment of codeine dependence / Myroslava K. Romach en Journal of Clinical Psychopharmacology, Año 2000 - Vol. 20 - No. 1 (Febrero)

Público ISBD [artículo]  inJournal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 43-45 Título : Cytochrome p450 2d6 and treatment of codeine dependence Tipo de documento: texto impreso Autores: Myroslava K. Romach, Autor ; S. Victoria Otton, Autor ; Gail Somer, Autor Fecha de publicación: 2023 Artículo en la página: pp. 43-45 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Analgésicos, Opioides, Codeína, Citocromo P-450 CYP2D6, Fluoxetina, Trastornos relacionados con opioides. Resumen: Oral opioid analgesics such as codeine are used extensively worldwide and are frequently misused. Codeine is a substrate of CYP2D6, a genetically polymorphic P450 enzyme, and is metabolized to the more potent drug morphine. CYP2D6 activity can be inhibited by fluoxetine, and the inhibition of morphine formation may help individuals reduce their use of codeine. Link: ./index.php?lvl=notice_display&id=31230 [artículo] Cytochrome p450 2d6 and treatment of codeine dependence [texto impreso] / Myroslava K. Romach, Autor ; S. Victoria Otton, Autor ; Gail Somer, Autor . - 2023 . - pp. 43-45. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of Clinical Psychopharmacology > Año 2000 - Vol. 20 - No. 1 (Febrero) . - pp. 43-45 Palabras clave: Analgésicos, Opioides, Codeína, Citocromo P-450 CYP2D6, Fluoxetina, Trastornos relacionados con opioides. Resumen: Oral opioid analgesics such as codeine are used extensively worldwide and are frequently misused. Codeine is a substrate of CYP2D6, a genetically polymorphic P450 enzyme, and is metabolized to the more potent drug morphine. CYP2D6 activity can be inhibited by fluoxetine, and the inhibition of morphine formation may help individuals reduce their use of codeine. Link: ./index.php?lvl=notice_display&id=31230

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