Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation / Guy Hindley en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 11 (Noviembre)

Público ISBD [artículo]  inThe American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 833-843 Título : Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation Tipo de documento: texto impreso Autores: Guy Hindley, Autor ; Oleksandr Frei, Autor ; Alexey A. Shadrin, Autor Fecha de publicación: 2023 Artículo en la página: pp. 833-843 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Genética - Genómica, Trastornos bipolares y relacionados, Trastornos depresivos, Trastornos del neurodesarrollo, Trastorno por déficit de atención con hiperactividad (TDAH), Espectro de esquizofrenia y otros trastornos psicóticos Resumen: Mental disorders are heritable and polygenic, and genome-wide genetic correlations (rg) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, rg may underestimate the shared genetic underpinnings of mental disorders and related traits because it does not differentiate mixtures of concordant and discordant genetic effects from an absence of genetic overlap. Link: ./index.php?lvl=notice_display&id=29767 [artículo] Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation [texto impreso] / Guy Hindley, Autor ; Oleksandr Frei, Autor ; Alexey A. Shadrin, Autor . - 2023 . - pp. 833-843. Idioma : Inglés (eng) Idioma original : Inglés (eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 11 (Noviembre) . - pp. 833-843 Palabras clave: Genética - Genómica, Trastornos bipolares y relacionados, Trastornos depresivos, Trastornos del neurodesarrollo, Trastorno por déficit de atención con hiperactividad (TDAH), Espectro de esquizofrenia y otros trastornos psicóticos Resumen: Mental disorders are heritable and polygenic, and genome-wide genetic correlations (rg) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, rg may underestimate the shared genetic underpinnings of mental disorders and related traits because it does not differentiate mixtures of concordant and discordant genetic effects from an absence of genetic overlap. Link: ./index.php?lvl=notice_display&id=29767

Novel Loci Associated With Attention-Deficit/Hyperactivity Disorder Are Revealed by Leveraging Polygenic Overlap With Educational Attainment / Alexey A. Shadrin en Journal of the American Academy of Child & Adolescent Psychiatry, Año 2018 - Vol. 57 - No.2 ([13/04/2018])

Público ISBD [artículo]  inJournal of the American Academy of Child & Adolescent Psychiatry > Año 2018 - Vol. 57 - No.2 [13/04/2018] . - pp. 86-95 Título : Novel Loci Associated With Attention-Deficit/Hyperactivity Disorder Are Revealed by Leveraging Polygenic Overlap With Educational Attainment Tipo de documento: texto impreso Autores: Alexey A. Shadrin, Autor ; Olav B. Smeland, Autor ; Tetyana Zayats, Autor Fecha de publicación: 2018 Artículo en la página: pp. 86-95 Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave: Trastorno por déficit de atención e hiperactividad, Nivel educativo, ïndice de descubrimiento falso condicional - conjuntivo, Superposición genética. Resumen: Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric condition. By exploiting the reported relationship between ADHD and educational attainment (EA), we aimed to improve discovery of ADHD-associated genetic variants and to investigate genetic overlap between these phenotypes. Link: ./index.php?lvl=notice_display&id=10424 [artículo] Novel Loci Associated With Attention-Deficit/Hyperactivity Disorder Are Revealed by Leveraging Polygenic Overlap With Educational Attainment [texto impreso] / Alexey A. Shadrin, Autor ; Olav B. Smeland, Autor ; Tetyana Zayats, Autor . - 2018 . - pp. 86-95. Idioma : Inglés (eng) Idioma original : Inglés (eng) in Journal of the American Academy of Child & Adolescent Psychiatry > Año 2018 - Vol. 57 - No.2 [13/04/2018] . - pp. 86-95 Palabras clave: Trastorno por déficit de atención e hiperactividad, Nivel educativo, ïndice de descubrimiento falso condicional - conjuntivo, Superposición genética. Resumen: Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric condition. By exploiting the reported relationship between ADHD and educational attainment (EA), we aimed to improve discovery of ADHD-associated genetic variants and to investigate genetic overlap between these phenotypes. Link: ./index.php?lvl=notice_display&id=10424

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