[artículo]
| Título : |
Item level genome wide association study of the alcohol use disorders identification test in three population based cohorts |
| Tipo de documento: |
texto impreso |
| Autores: |
Travis T. Mallard, Autor ; Jeanne Savage, Autor ; Emma C. Johnson, Autor |
| Fecha de publicación: |
2022 |
| Artículo en la página: |
pp. 58-70 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
GWAS, Trastornos adictivos relacionados con sustancias, Alcohol, Modelado de ecuaciones estructurales genómicas, Consumo de alcohol, ALSPAC |
| Resumen: |
Genome-wide association studies (GWASs) of the Alcohol Use Disorders Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated novel loci for alcohol consumption and misuse. However, these studies also revealed that GWASs can be influenced by numerous biases (e.g., measurement error, selection bias), which may have led to inconsistent genetic correlations between alcohol involvement and AUD, as well as paradoxically negative genetic correlations between alcohol involvement and psychiatric disorders and/or medical conditions. |
| Link: |
./index.php?lvl=notice_display&id=28326 |
in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 1 (Enero) . - pp. 58-70
[artículo] Item level genome wide association study of the alcohol use disorders identification test in three population based cohorts [texto impreso] / Travis T. Mallard, Autor ; Jeanne Savage, Autor ; Emma C. Johnson, Autor . - 2022 . - pp. 58-70. Idioma : Inglés ( eng) Idioma original : Inglés ( eng) in The American Journal of Psychiatry > Año 2022 - Vol. 179 - No. 1 (Enero) . - pp. 58-70
| Palabras clave: |
GWAS, Trastornos adictivos relacionados con sustancias, Alcohol, Modelado de ecuaciones estructurales genómicas, Consumo de alcohol, ALSPAC |
| Resumen: |
Genome-wide association studies (GWASs) of the Alcohol Use Disorders Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated novel loci for alcohol consumption and misuse. However, these studies also revealed that GWASs can be influenced by numerous biases (e.g., measurement error, selection bias), which may have led to inconsistent genetic correlations between alcohol involvement and AUD, as well as paradoxically negative genetic correlations between alcohol involvement and psychiatric disorders and/or medical conditions. |
| Link: |
./index.php?lvl=notice_display&id=28326 |
|
Item level genome wide association study of the alcohol use disorders identification test in three population based cohorts en The American Journal of Psychiatry, Año 2022 - Vol. 179 - No. 1 (Enero)
