[artículo] 
inThe Canadian Journal of Psychiatry > Año 2000 Vol. 45 - No.3 (Abril) . - pp. 241–246

Título :	Are animal studies of antipsychotics appropriately dosed? Lessons from the bedside to the bench
Tipo de documento:	texto impreso
Autores:	Shitij Kapur, Autor ; Marie Louise Wadenberg, Autor ; Gary Remington, Autor
Fecha de publicación:	2022
Artículo en la página:	pp. 241–246
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Antipsicóticos, Modelos de enfermedades, Antagonistas de la dopamina, Haloperidol, Racloprida, Estudio en Ratas, Esquizofrenia - terapia farmacológica.
Resumen:	Animal models are crucial for understanding the mechanism of action of antipsychotics. However, the dose of an antipsychotic in animal studies is often arbitrarily chosen, with haloperidol 1 mg/kg being a rather common standard. Recent clinical positron emission tomography (PET) studies in patients show all antipsychotics to block dopamine D2 receptors, and most are effective at doses that lead to 60% to 80% D2 occupancy.
Link:	./index.php?lvl=notice_display&id=29042

[artículo] Are animal studies of antipsychotics appropriately dosed? Lessons from the bedside to the bench [texto impreso] / Shitij Kapur, Autor ; Marie Louise Wadenberg, Autor ; Gary Remington, Autor . - 2022 . - pp. 241–246.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in The Canadian Journal of Psychiatry > Año 2000 Vol. 45 - No.3 (Abril) . - pp. 241–246

Palabras clave:	Antipsicóticos, Modelos de enfermedades, Antagonistas de la dopamina, Haloperidol, Racloprida, Estudio en Ratas, Esquizofrenia - terapia farmacológica.
Resumen:	Animal models are crucial for understanding the mechanism of action of antipsychotics. However, the dose of an antipsychotic in animal studies is often arbitrarily chosen, with haloperidol 1 mg/kg being a rather common standard. Recent clinical positron emission tomography (PET) studies in patients show all antipsychotics to block dopamine D2 receptors, and most are effective at doses that lead to 60% to 80% D2 occupancy.
Link:	./index.php?lvl=notice_display&id=29042