[artículo]
| Título : |
A comparison of the effects of olanzapine and risperidone versus placebo on ghrelin plasma levels |
| Tipo de documento: |
texto impreso |
| Autores: |
James L. Roerig, Autor ; Kristine J. Steffen, Autor ; James E. Mitchell, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 21-26 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Antipsicóticos, Benzodiazepinas, Comportamiento alimentario, Risperidona |
| Resumen: |
To thoroughly investigate the phenomenon of atypical antipsychotic-associated weight gain, a feeding laboratory paradigm was developed that included obtaining plasma levels of the orexigenic peptide ghrelin that is associated with appetite and eating. This study is a randomized, double-blind, parallel group trial comparing the effects of a 2-week exposure to olanzapine, risperidone, or placebo on plasma ghrelin area under the plasma-time curve (AUC) in 28 healthy human subjects. Subjects were randomized to receive olanzapine, risperidone, or placebo and titrated over 4 days to 10 mg/d or 4 mg/d, respectively. |
| Link: |
./index.php?lvl=notice_display&id=30868 |
in Journal of Clinical Psychopharmacology > Año 2008 - Vol. 28 - No. 1 (Febrero) . - pp. 21-26
[artículo] A comparison of the effects of olanzapine and risperidone versus placebo on ghrelin plasma levels [texto impreso] / James L. Roerig, Autor ; Kristine J. Steffen, Autor ; James E. Mitchell, Autor . - 2023 . - pp. 21-26. Idioma : Inglés ( eng) Idioma original : Inglés ( eng) in Journal of Clinical Psychopharmacology > Año 2008 - Vol. 28 - No. 1 (Febrero) . - pp. 21-26
| Palabras clave: |
Antipsicóticos, Benzodiazepinas, Comportamiento alimentario, Risperidona |
| Resumen: |
To thoroughly investigate the phenomenon of atypical antipsychotic-associated weight gain, a feeding laboratory paradigm was developed that included obtaining plasma levels of the orexigenic peptide ghrelin that is associated with appetite and eating. This study is a randomized, double-blind, parallel group trial comparing the effects of a 2-week exposure to olanzapine, risperidone, or placebo on plasma ghrelin area under the plasma-time curve (AUC) in 28 healthy human subjects. Subjects were randomized to receive olanzapine, risperidone, or placebo and titrated over 4 days to 10 mg/d or 4 mg/d, respectively. |
| Link: |
./index.php?lvl=notice_display&id=30868 |
|
A comparison of the effects of olanzapine and risperidone versus placebo on ghrelin plasma levels en Journal of Clinical Psychopharmacology, Año 2008 - Vol. 28 - No. 1 (Febrero)
