[artículo] 
inJournal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 6 (Diciembre) . - pp. 647-652

Título :	Impact of the cyp2d6 ultrarapid metabolizer genotype on mirtazapine pharmacokinetics and adverse events in healthy volunteers
Tipo de documento:	texto impreso
Autores:	Julia Kirchheiner, Autor ; Hanns Benjamin Henckel, Autor ; Ingolf Meineke, Autor
Fecha de publicación:	2023
Artículo en la página:	pp. 647-652
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Intervalos de confianza, Citocromo P-450 CYP2D6, Frecuencia genética, Tasa de aclaramiento metabólico, Mianserina.
Resumen:	In vitro studies showed that biotransformation of the antidepressant drug mirtazapine is mediated by cytochrome P-450 enzymes CYP1A2, CYP2D6, and CYP3A4 with CYP2D6 contributing about 35% to total mirtazapine biotransformation. We hypothesized that ultrarapid metabolizers (defined as carriers of the CYP2D6 gene duplication plus another functional allele) have a risk for therapeutic failure due to too low tissue concentrations.
Link:	./index.php?lvl=notice_display&id=30939

[artículo] Impact of the cyp2d6 ultrarapid metabolizer genotype on mirtazapine pharmacokinetics and adverse events in healthy volunteers [texto impreso] / Julia Kirchheiner, Autor ; Hanns Benjamin Henckel, Autor ; Ingolf Meineke, Autor . - 2023 . - pp. 647-652.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 6 (Diciembre) . - pp. 647-652

Palabras clave:	Intervalos de confianza, Citocromo P-450 CYP2D6, Frecuencia genética, Tasa de aclaramiento metabólico, Mianserina.
Resumen:	In vitro studies showed that biotransformation of the antidepressant drug mirtazapine is mediated by cytochrome P-450 enzymes CYP1A2, CYP2D6, and CYP3A4 with CYP2D6 contributing about 35% to total mirtazapine biotransformation. We hypothesized that ultrarapid metabolizers (defined as carriers of the CYP2D6 gene duplication plus another functional allele) have a risk for therapeutic failure due to too low tissue concentrations.
Link:	./index.php?lvl=notice_display&id=30939