[artículo]
| Título : |
Effects of isradipine on cocaine induced subjective mood |
| Tipo de documento: |
texto impreso |
| Autores: |
Bankole A. Johnson, Autor ; John D. Roache, Autor ; Nassima Ait Daoud, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 180-191 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Afecto, Bloqueadores de los canales de calcio, Bloqueadores de los canales de calcio, Cocaína - farmacología, Trastornos relacionados con la cocaína, Dopamina, Isradipina. |
| Resumen: |
We hypothesized that in humans, as in animals, isradipine, a dihydropyridine-class calcium channel antagonist, would antagonize cocaine's rewarding effects, based on preclinical evidence that isradipine inhibits cocaine-mediated increases in mesolimbic dopamine (DA), thereby reducing cocaine's abuse liability. Confirmation of our hypothesis would make isradipine a promising medication for treating cocaine dependence. |
| Link: |
./index.php?lvl=notice_display&id=30968 |
in Journal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 2 (Abril) . - pp. 180-191
[artículo] Effects of isradipine on cocaine induced subjective mood [texto impreso] / Bankole A. Johnson, Autor ; John D. Roache, Autor ; Nassima Ait Daoud, Autor . - 2023 . - pp. 180-191. Idioma : Inglés ( eng) Idioma original : Inglés ( eng) in Journal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 2 (Abril) . - pp. 180-191
| Palabras clave: |
Afecto, Bloqueadores de los canales de calcio, Bloqueadores de los canales de calcio, Cocaína - farmacología, Trastornos relacionados con la cocaína, Dopamina, Isradipina. |
| Resumen: |
We hypothesized that in humans, as in animals, isradipine, a dihydropyridine-class calcium channel antagonist, would antagonize cocaine's rewarding effects, based on preclinical evidence that isradipine inhibits cocaine-mediated increases in mesolimbic dopamine (DA), thereby reducing cocaine's abuse liability. Confirmation of our hypothesis would make isradipine a promising medication for treating cocaine dependence. |
| Link: |
./index.php?lvl=notice_display&id=30968 |
|
Effects of isradipine on cocaine induced subjective mood en Journal of Clinical Psychopharmacology, Año 2004 - Vol. 24 - No. 2 (Abril)
