[artículo] 
inJournal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 1 (Febrero) . - pp. 62-69

Título :	A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition
Tipo de documento:	texto impreso
Autores:	Edmund P. Harrigan, Autor ; Jeffrey J. Miceli, Autor ; Richard Anziano, Autor
Fecha de publicación:	2023
Artículo en la página:	pp. 62-69
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Antipsicóticos, Aril Hidrocarburo Hidroxilasas, Benzodiazepinas, Clozapina, Dibenzotiazepinas, Electrocardiografía, Haloperidol, Sistema de conducción del corazón, Síndrome de QT largo, Olanzapina, Fumarato de quetiapina, Risperidona, Tioridazina.
Resumen:	Many drugs have been associated with QTc prolongation and, in some cases, this is augmented by concomitant administration with metabolic inhibitors. The effects of 6 antipsychotics on the QTc interval at and around the time of estimated peak plasma/serum concentrations in the absence and presence of metabolic inhibition were characterized in a prospective, randomized study in which patients with psychotic disorders reached steady-state on either haloperidol 15 mg/d (n = 27), thioridazine 300 mg/d (n = 30), ziprasidone 160 mg/d (n = 31), quetiapine 750 mg/d (n = 27), olanzapine 20 mg/d (n = 24), or risperidone 6-8 mg/d increased to 16 mg/d (n = 25/20).
Link:	./index.php?lvl=notice_display&id=30980

[artículo] A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition [texto impreso] / Edmund P. Harrigan, Autor ; Jeffrey J. Miceli, Autor ; Richard Anziano, Autor . - 2023 . - pp. 62-69.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 1 (Febrero) . - pp. 62-69

Palabras clave:	Antipsicóticos, Aril Hidrocarburo Hidroxilasas, Benzodiazepinas, Clozapina, Dibenzotiazepinas, Electrocardiografía, Haloperidol, Sistema de conducción del corazón, Síndrome de QT largo, Olanzapina, Fumarato de quetiapina, Risperidona, Tioridazina.
Resumen:	Many drugs have been associated with QTc prolongation and, in some cases, this is augmented by concomitant administration with metabolic inhibitors. The effects of 6 antipsychotics on the QTc interval at and around the time of estimated peak plasma/serum concentrations in the absence and presence of metabolic inhibition were characterized in a prospective, randomized study in which patients with psychotic disorders reached steady-state on either haloperidol 15 mg/d (n = 27), thioridazine 300 mg/d (n = 30), ziprasidone 160 mg/d (n = 31), quetiapine 750 mg/d (n = 27), olanzapine 20 mg/d (n = 24), or risperidone 6-8 mg/d increased to 16 mg/d (n = 25/20).
Link:	./index.php?lvl=notice_display&id=30980