[artículo]
| Título : |
Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual patients |
| Tipo de documento: |
texto impreso |
| Autores: |
Amin Rostami Hodjegan, Autor ; Ajmal M. Amin, Autor ; Edgar P. Spencer, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 70-78 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Envejecimiento, Peso corporal, Clozapina, Relación dosis-respuesta, Modelos Biológicos, Cumplimiento del paciente, Tabaquismo - metabolismo |
| Resumen: |
The measurement of plasma clozapine concentrations is useful in assessing compliance, optimizing therapy, and minimizing toxicity.
We measured plasma clozapine and norclozapine (N-desmethylclozapine) concentrations in samples from 3782 patients (2648 male, 1127 female). No clozapine was detected in 291 samples (227 patients, median prescribed dose 300 mg/d). |
| Link: |
./index.php?lvl=notice_display&id=30981 |
in Journal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 1 (Febrero) . - pp. 70-78
[artículo] Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual patients [texto impreso] / Amin Rostami Hodjegan, Autor ; Ajmal M. Amin, Autor ; Edgar P. Spencer, Autor . - 2023 . - pp. 70-78. Idioma : Inglés ( eng) Idioma original : Inglés ( eng) in Journal of Clinical Psychopharmacology > Año 2004 - Vol. 24 - No. 1 (Febrero) . - pp. 70-78
| Palabras clave: |
Envejecimiento, Peso corporal, Clozapina, Relación dosis-respuesta, Modelos Biológicos, Cumplimiento del paciente, Tabaquismo - metabolismo |
| Resumen: |
The measurement of plasma clozapine concentrations is useful in assessing compliance, optimizing therapy, and minimizing toxicity.
We measured plasma clozapine and norclozapine (N-desmethylclozapine) concentrations in samples from 3782 patients (2648 male, 1127 female). No clozapine was detected in 291 samples (227 patients, median prescribed dose 300 mg/d). |
| Link: |
./index.php?lvl=notice_display&id=30981 |
|
Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual patients en Journal of Clinical Psychopharmacology, Año 2004 - Vol. 24 - No. 1 (Febrero)
