[artículo] 
inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 471-478

Título :	Dose-related pharmacokinetics and pharmacodynamics of valproate in the elderly
Tipo de documento:	texto impreso
Autores:	Susy Felix, Autor ; Beth A. Sproule, Autor ; Brian G. Hardy, Autor
Fecha de publicación:	2023
Artículo en la página:	pp. 471-478
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Tasa de aclaramiento metabólico, Ácido Valproico.
Resumen:	Valproate exhibits a complex pharmacokinetic profile due to concentration-dependent protein binding and clearance. It has been shown that the protein binding of valproate decreases as the serum concentration increases in a young adult population. Furthermore, the percentage of protein binding is lower in the elderly compared with young adults at comparable low therapeutic serum concentrations.
Link:	./index.php?lvl=notice_display&id=31001

[artículo] Dose-related pharmacokinetics and pharmacodynamics of valproate in the elderly [texto impreso] / Susy Felix, Autor ; Beth A. Sproule, Autor ; Brian G. Hardy, Autor . - 2023 . - pp. 471-478.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 5 (Octubre) . - pp. 471-478

Palabras clave:	Tasa de aclaramiento metabólico, Ácido Valproico.
Resumen:	Valproate exhibits a complex pharmacokinetic profile due to concentration-dependent protein binding and clearance. It has been shown that the protein binding of valproate decreases as the serum concentration increases in a young adult population. Furthermore, the percentage of protein binding is lower in the elderly compared with young adults at comparable low therapeutic serum concentrations.
Link:	./index.php?lvl=notice_display&id=31001