[artículo] 
inJournal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 2 (Abril) . - pp. 169-175

Título :	The role of cytochrome p450 2c19 activity in flunitrazepam metabolism in vivo
Tipo de documento:	texto impreso
Autores:	Inbal Gafni M., Autor ; Usoa E. Busto, Autor ; Rachel F. Tyndale, Autor
Fecha de publicación:	2023
Artículo en la página:	pp. 169-175
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Ansiolíticos, Cromatografía líquida, Citocromo P-450 CYP2C19, Flunitrazepam.
Resumen:	Flunitrazepam, a hypnotic benzodiazepine, is widely prescribed around the world for the treatment of insomnia and as a preanesthetic. In vitro studies have shown that the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam is mediated in part by the polymorphic enzyme CYP2C19. The objective was to examine the role of CYP2C19 activity in determining flunitrazepam kinetics in vivo.
Link:	./index.php?lvl=notice_display&id=31034

[artículo] The role of cytochrome p450 2c19 activity in flunitrazepam metabolism in vivo [texto impreso] / Inbal Gafni M., Autor ; Usoa E. Busto, Autor ; Rachel F. Tyndale, Autor . - 2023 . - pp. 169-175.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of Clinical Psychopharmacology > Año 2003 - Vol. 23 - No. 2 (Abril) . - pp. 169-175

Palabras clave:	Ansiolíticos, Cromatografía líquida, Citocromo P-450 CYP2C19, Flunitrazepam.
Resumen:	Flunitrazepam, a hypnotic benzodiazepine, is widely prescribed around the world for the treatment of insomnia and as a preanesthetic. In vitro studies have shown that the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam is mediated in part by the polymorphic enzyme CYP2C19. The objective was to examine the role of CYP2C19 activity in determining flunitrazepam kinetics in vivo.
Link:	./index.php?lvl=notice_display&id=31034