[artículo]
| Título : |
In vitro inhibition of pimozide n-dealkylation by selective serotonin reuptake inhibitors and azithromycin |
| Tipo de documento: |
texto impreso |
| Autores: |
Zeruesenay Desta, Autor ; Nadia Soukhova, Autor ; David A. Flockhart, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 162-168 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Azitromicina, Inhibidores de la enzima citocromo P-450, Técnicas In Vitro, Microsomas, Oxidorreductasas. |
| Resumen: |
Pimozide is often coprescribed with serotonin reuptake inhibitor (SSRI) antidepressants to treat depression in patients with Tourette’s syndrome. In human liver microsomes (HLMs), the inhibition of the primary route of pimozide metabolism, N-dealkylation to 1,3-dihydro-1-(4–piperidinyl)-2H-benzimidazol-2-one (DHPBI), by four SSRIs (fluoxetine, sertraline, paroxetine, and fluvoxamine) and azithromycin was tested. |
| Link: |
./index.php?lvl=notice_display&id=31081 |
in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 2 (Abril) . - pp. 162-168
[artículo] In vitro inhibition of pimozide n-dealkylation by selective serotonin reuptake inhibitors and azithromycin [texto impreso] / Zeruesenay Desta, Autor ; Nadia Soukhova, Autor ; David A. Flockhart, Autor . - 2023 . - pp. 162-168. Idioma : Inglés ( eng) Idioma original : Inglés ( eng) in Journal of Clinical Psychopharmacology > Año 2002 - Vol. 22 - No. 2 (Abril) . - pp. 162-168
| Palabras clave: |
Azitromicina, Inhibidores de la enzima citocromo P-450, Técnicas In Vitro, Microsomas, Oxidorreductasas. |
| Resumen: |
Pimozide is often coprescribed with serotonin reuptake inhibitor (SSRI) antidepressants to treat depression in patients with Tourette’s syndrome. In human liver microsomes (HLMs), the inhibition of the primary route of pimozide metabolism, N-dealkylation to 1,3-dihydro-1-(4–piperidinyl)-2H-benzimidazol-2-one (DHPBI), by four SSRIs (fluoxetine, sertraline, paroxetine, and fluvoxamine) and azithromycin was tested. |
| Link: |
./index.php?lvl=notice_display&id=31081 |
|
In vitro inhibition of pimozide n-dealkylation by selective serotonin reuptake inhibitors and azithromycin en Journal of Clinical Psychopharmacology, Año 2002 - Vol. 22 - No. 2 (Abril)
