[artículo] 
inJournal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 2 (Abril) . - pp. 175-184

Título :	Diphenhydramine alters the disposition of venlafaxine through inhibition of cyp2d6 activity in humans
Tipo de documento:	texto impreso
Autores:	Étienne Lessard, Autor ; Marie Andrée Yessine, Autor ; Bettina A. Hamelin, Autor
Fecha de publicación:	2023
Artículo en la página:	pp. 175-184
Idioma :	Inglés (eng) Idioma original : Inglés (eng)
Palabras clave:	Antidepresivos, Ciclohexanoles, Citocromo P-450 CYP2D6, Difenhidramina, Interacción medicamentosa.
Resumen:	CYP2D6 is the major enzyme involved in the metabolism of venlafaxine. Subjects with a low CYP2D6 activity have increased plasma concentrations of venlafaxine that may predispose them to cardiovascular side effects. In vitro and in vivo studies showed that diphenhydramine, a nonprescription antihistamine, can inhibit CYP2D6 activity. Therefore, the authors investigated in this study a potential drug interaction between diphenhydramine and venlafaxine.
Link:	./index.php?lvl=notice_display&id=31122

[artículo] Diphenhydramine alters the disposition of venlafaxine through inhibition of cyp2d6 activity in humans [texto impreso] / Étienne Lessard, Autor ; Marie Andrée Yessine, Autor ; Bettina A. Hamelin, Autor . - 2023 . - pp. 175-184.
Idioma : Inglés (eng) Idioma original : Inglés (eng)
in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 2 (Abril) . - pp. 175-184

Palabras clave:	Antidepresivos, Ciclohexanoles, Citocromo P-450 CYP2D6, Difenhidramina, Interacción medicamentosa.
Resumen:	CYP2D6 is the major enzyme involved in the metabolism of venlafaxine. Subjects with a low CYP2D6 activity have increased plasma concentrations of venlafaxine that may predispose them to cardiovascular side effects. In vitro and in vivo studies showed that diphenhydramine, a nonprescription antihistamine, can inhibit CYP2D6 activity. Therefore, the authors investigated in this study a potential drug interaction between diphenhydramine and venlafaxine.
Link:	./index.php?lvl=notice_display&id=31122