Biblioteca Humberto Rosselli Quijano
[artículo]
| Título : |
Cytochrome p450 2d6 genotype and methadone steady-state concentrations |
| Tipo de documento: |
texto impreso |
| Autores: |
Chin B. Eap, Autor ; Franck Broly, Autor ; Annie Mino, Autor |
| Fecha de publicación: |
2023 |
| Artículo en la página: |
pp. 229-234 |
| Idioma : |
Inglés (eng) Idioma original : Inglés (eng) |
| Palabras clave: |
Citocromo P-450 CYP2D6, Metadona, Narcóticos, Estupefacientes - uso terapéutico, Trastornos relacionados con los opioides. |
| Resumen: |
A genetic polymorphism of cytochrome P450 2D6 has been described with the existence of poor (zero functional genes), extensive (one or two functional genes), and ultrarapid metabolizers (three or more functional genes). The authors measured the steady-state trough (R)- (i.e., the active enantiomer), (S)-, and (R,S)-methadone plasma levels in opiate-dependent patients receiving methadone maintenance treatment (MMT) and genotyped them for cytochrome P4502D6. |
| Link: |
./index.php?lvl=notice_display&id=31129 |
in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 2 (Abril) . - pp. 229-234
[artículo] Cytochrome p450 2d6 genotype and methadone steady-state concentrations [texto impreso] / Chin B. Eap, Autor ; Franck Broly, Autor ; Annie Mino, Autor . - 2023 . - pp. 229-234. Idioma : Inglés ( eng) Idioma original : Inglés ( eng) in Journal of Clinical Psychopharmacology > Año 2001 - Vol. 21 - No. 2 (Abril) . - pp. 229-234
| Palabras clave: |
Citocromo P-450 CYP2D6, Metadona, Narcóticos, Estupefacientes - uso terapéutico, Trastornos relacionados con los opioides. |
| Resumen: |
A genetic polymorphism of cytochrome P450 2D6 has been described with the existence of poor (zero functional genes), extensive (one or two functional genes), and ultrarapid metabolizers (three or more functional genes). The authors measured the steady-state trough (R)- (i.e., the active enantiomer), (S)-, and (R,S)-methadone plasma levels in opiate-dependent patients receiving methadone maintenance treatment (MMT) and genotyped them for cytochrome P4502D6. |
| Link: |
./index.php?lvl=notice_display&id=31129 |
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